Oral lyophylizate formulation of desmopressin: Superior pharmacodynamics compared to tablet due to low food interaction

Journal of Urology

Volumn 185, Issue 6, 2011, Pages 2308-2313

  De Guchtenaere, A ^a   Van Herzeele, C ^a   Raes, A ^a   Dehoorne, J ^a   Hoebeke, P ^a   Van Laecke, E ^a   Vande Walle, J ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

administration; biological availability; deamino arginine vasopressin; food drug interactions; freeze drying; sublingual

Indexed keywords

DESMOPRESSIN; DESMOPRESSIN ACETATE;

ANTIDIURESIS; ARTICLE; CHILD; CONTROLLED STUDY; DIURESIS; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG SOLUBILITY; DRUG URINE LEVEL; FEMALE; FOOD INTAKE; HUMAN; HUMAN EXPERIMENT; INTERMETHOD COMPARISON; LYOPHILISATE; MALE; MEAL; NORMAL HUMAN; PRIORITY JOURNAL; SCHOOL CHILD; TABLET FORMULATION; URINE OSMOLALITY; WATER LOADING;

ANTIDIURETIC AGENTS; CHEMISTRY, PHARMACEUTICAL; CHILD; DEAMINO ARGININE VASOPRESSIN; FEMALE; FOOD-DRUG INTERACTIONS; HUMANS; MALE; NOCTURNAL ENURESIS; TABLETS; THERAPEUTIC EQUIVALENCY;

EID: 79955838554     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.juro.2011.02.039     Document Type: Article

References (24)

1. C.M. Glazener, and J.H. Evans Desmopressin for nocturnal enuresis in children Cochrane Database Syst Rev 2 2000 CD002112
2. C.M. Glazener, and J.H. Evans Alarm interventions for nocturnal enuresis in children Cochrane Database Syst Rev 1 2001 CD002911
3. T. Neveus, P. Eggert, and J. Evans Evaluation of and treatment for monosymptomatic enuresis: a standardization document from the International Children's Continence Society J Urol 183 2010 441
4. M.E. Moffatt, S. Harlos, and A.J. Kirshen Desmopressin acetate and nocturnal enuresis: how much do we know? Pediatrics 92 1993 420
5. T. Nevus, A. von Gontard, and P. Hoebeke The standardization of terminology of lower urinary tract function in children and adolescents: report from the Standardisation Committee of the International Children's Continence Society J Urol 176 2006 314
6. K. Kamperis, S. Hagstroem, and S. Rittig The effect of sleep on nocturnal urine output Neurourol Urodyn, suppl 24 2005 457
7. K. Kamperis, S. Rittig, and K.A. Jorgensen Nocturnal polyuria in monosymptomatic nocturnal enuresis refractory to desmopressin treatment Am J Physiol Renal Physiol 291 2006 F1232
8. A. Raes, J. Dehoorne, and E. Van Laecke Partial response to intranasal desmopressin in children with monosymptomatic nocturnal enuresis is related to persistent nocturnal polyuria on wet nights J Urol 178 2007 1048
9. A. Raes, J. Dehoorne, and P. Hoebeke Abnormal circadian rhythm of diuresis or nocturnal polyuria in a subgroup of children with enuresis and hypercalciuria is related to increased sodium retention during daytime J Urol 176 2006 1147
10. J. Vande Walle, C. Vande Walle, and P. Van Sintjan Nocturnal polyuria is related to 24-hour diuresis and osmotic excretion in an enuresis population referred to a tertiary center J Urol 178 2007 2630
11. K. Dhondt, A. Raes, and P. Hoebeke Abnormal sleep architecture and refractory nocturnal enuresis J Urol 182 2009 1961
12. A. De Guchtenaere, A. Raes, and C. Vande Walle Evidence of partial anti-enuretic response related to poor pharmacodynamic effects of desmopressin nasal spray J Urol 181 2009 302
13. C. Van Herzeele, I. Alova, and J. Evans Poor compliance with primary nocturnal enuresis therapy may contribute to insufficient desmopressin response J Urol 182 2009 2045
14. H. Lottmann, F. Froeling, and S. Alloussi A randomised comparison of oral desmopressin lyophilisate (MELT) and tablet formulations in children and adolescents with primary nocturnal enuresis Int J Clin Pract 61 2007 1454
15. J.P. Nørgaard A clinical and pharmacological model for explaining response to desmopressin Scand J Urol Nephrol Suppl 202 1999 53
16. R.A. Janknegt, H.M. Zweers, and K.P. Delaere Oral desmopressin as a new treatment modality for primary nocturnal enuresis in adolescents and adults: a double-blind, randomized, multicenter study Dutch Enuresis Study Group J Urol 157 1997 513
17. A. Fjellestad-Paulsen, S. Wille, and A.S. Harris Comparison of intranasal and oral desmopressin for nocturnal enuresis Arch Dis Child 62 1987 674
18. S. Rittig, A.R. Jensen, and K.T. Jensen Effect of food intake on the pharmacokinetics and antidiuretic activity of oral desmopressin (DDAVP) in hydrated normal subjects Clin Endocrinol (Oxf) 48 1998 235
19. T. Callreus, J. Lundahl, and P. Hoglund Changes in gastrointestinal motility influence the absorption of desmopressin Eur J Clin Pharmacol 55 1999 305
20. G.M. Hvistendahl, A. Riis, and J.P. Nørgaard The pharmacokinetics of 400 microg of oral desmopressin in elderly patients with nocturia, and the correlation between the absorption of desmopressin and clinical effect BJU Int 95 2005 804
21. K.S. Lam, M.S. Wat, and K.L. Choi Pharmacokinetics, pharmacodynamics, long-term efficacy and safety of oral 1-deamino-8-D-arginine vasopressin in adult patients with central diabetes insipidus Br J Clin Pharmacol 42 1996 379
22. J.G. Vande Walle, G.A. Bogaert, and S. Mattsson A new fast-melting oral formulation of desmopressin: a pharmacodynamic study in children with primary nocturnal enuresis BJU Int 97 2006 603
23. O. Osterberg, R.M. Savic, and M.O. Karlsson Pharmacokinetics of desmopressin administrated as an oral lyophilisate dosage form in children with primary nocturnal enuresis and healthy adults J Clin Pharmacol 46 2006 1204
24. A. Rembratt, C. Graugaard-Jensen, and T. Senderovitz Pharmacokinetics and pharmacodynamics of desmopressin administered orally versus intravenously at daytime versus nighttime in healthy men aged 55-70 years Eur J Clin Pharmacol 60 2004 397