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This is a useful algorithm for converting patients from U-100 insulin to U-500 insulin by either multiple daily injections or continuous subcutaneous infusion
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Lane WS, Cochran EK, Jackson JA, et al.: High-dose insulin therapy: is it time for U-500 insulin?, Endocr Pract 2009 15:71-79. This is a useful algorithm for converting patients from U-100 insulin to U-500 insulin by either multiple daily injections or continuous subcutaneous infusion.
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This is a pharmacokinetic study evaluating U-500 insulin in obese insulin-resistant diabetic subjects
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Davidson MB, Navar MD, Echeverry D, Duran P: U-500 regular insulin: clinical experience and pharmacokinetics in obese, severely insulin-resistant type 2 diabetic patients, Diabetes Care 2010 33:281-283. This is a pharmacokinetic study evaluating U-500 insulin in obese insulin-resistant diabetic subjects.
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A Prospective Trial of U-500 Insulin Delivered by Omnipod in Patients with Type 2 Diabetes and Severe Insulin Resistance
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This is a nice demonstration of improved glycemic control as evaluated by continuous glucose monitoring in subjects receiving U-500 insulin via continuous infusion. This study also demonstrates 12-month durability of glycemic control
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Lane WS, Weinrib SL, Rappaport JM, Przestrzelski T: A Prospective Trial of U-500 Insulin Delivered by Omnipod in Patients with Type 2 Diabetes and Severe Insulin Resistance, Endocr Pract 2010 1-30. This is a nice demonstration of improved glycemic control as evaluated by continuous glucose monitoring in subjects receiving U-500 insulin via continuous infusion. This study also demonstrates 12-month durability of glycemic control.
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Endocr Pract
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Lane, W.S.1
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