Mutations that replace aromatic side chains promote aggregation of the Alzheimers Aβ peptide

Biochemistry

Volumn 50, Issue 19, 2011, Pages 4058-4067

  Armstrong, Anne H ^a,b   Chen, Jermont ^a,c   McKoy, Angela Fortner ^a   Hecht, Michael H ^a  

^a PRINCETON UNIVERSITY   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c Air Force Materiel Command   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMERS DISEASE; AMINO ACID SEQUENCE; AMYLOID BETAS; AMYLOID FIBRIL; AMYLOID FORMATION; AROMATIC INHIBITORS; AROMATIC RESIDUES; AROMATIC SIDE CHAINS; AROMATICITIES; HUMAN DISEASE; SIDE-CHAINS; STACKING INTERACTION; WILD TYPES;

AMINO ACIDS; AROMATIC COMPOUNDS; GLYCOPROTEINS; NEURODEGENERATIVE DISEASES; PEPTIDES;

AROMATIZATION;

ALANINE; AMYLOID; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; ISOLEUCINE; LEUCINE; PHENYLALANINE; THIOFLAVINE;

ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; ELECTRON MICROSCOPY; FLUORESCENCE; GENE MUTATION; HYDROPHOBICITY; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN AGGREGATION;

ALANINE; ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMINO ACIDS, AROMATIC; AMYLOID BETA-PEPTIDES; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; ISOLEUCINE; LEUCINE; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PEPTIDE FRAGMENTS; PHENYLALANINE; PROTEIN PROCESSING, POST-TRANSLATIONAL;

EID: 79955806884     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200268w     Document Type: Article

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