Socioeconomic and psychological factors associated with nonadherence to treatment in inflammatory bowel disease patients: Results of the ISSEO survey

Inflammatory Bowel Diseases

Volumn 17, Issue 6, 2011, Pages 1270-1276

  Nahon, Stéphane ^a,e   Lahmek, Pierre ^a,b   Saas, Catherine ^c   Durance, Christelle ^d   Olympie, Alain ^d   Lesgourgues, Bruno ^a   Gendre, Jean Pierre ^d  

^a GHI le Raincy Montfermeil   (France)

^b Hôpitaux Universitaires Henri Mondor   (France)

^c Centre Technique d'Appui et de Formation des Centres d'Examens de Sante Cetaf   (France)

^d Association François Aupetit   (France)

^e Centre Hospitalier Intercommunal Le Raincy Montfermeil   (France)

Author keywords

adherence; Crohn's disease; IBD; medication; treatment; ulcerative colitis

Indexed keywords

BUDESONIDE; CORTICOSTEROID; IMMUNOSUPPRESSIVE AGENT; MERCAPTOPURINE; MESALAZINE; METHOTREXATE; PREDNISOLONE; TUMOR NECROSIS FACTOR ALPHA ANTIBODY;

ADULT; ANXIETY DISORDER; CORTICOSTEROID THERAPY; CROHN DISEASE; DEMOGRAPHY; DEPRESSION; DISEASE SEVERITY; EDUCATIONAL STATUS; EMPLOYMENT STATUS; ENTERITIS; FEMALE; HOSPITAL ANXIETY AND DEPRESSION SCALE; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; MAJOR CLINICAL STUDY; MALE; MARRIAGE; PATIENT COMPLIANCE; PRIORITY JOURNAL; PSYCHOLOGICAL ASPECT; QUESTIONNAIRE; REVIEW; SMOKING; SOCIOECONOMICS; ULCERATIVE COLITIS;

ADULT; ANALYSIS OF VARIANCE; CHI-SQUARE DISTRIBUTION; COLITIS, ULCERATIVE; CONFIDENCE INTERVALS; CROHN DISEASE; DEPRESSION; EDUCATIONAL STATUS; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INFLAMMATORY BOWEL DISEASES; LOGISTIC MODELS; MALE; MARITAL STATUS; MEDICATION ADHERENCE; ODDS RATIO; PSYCHIATRIC STATUS RATING SCALES; PSYCHOLOGY; QUESTIONNAIRES; SEVERITY OF ILLNESS INDEX; SEX FACTORS; SOCIOECONOMIC FACTORS;

EID: 79955797285     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1002/ibd.21482     Document Type: Review

References (26)

1. Baumgart DC, Sandborn WJ., Inflammatory bowel disease: clinical aspects and established and evolving therapies. Lancet. 2007; 369: 1641-1657. (Pubitemid 46722637)
2. Falagas ME, Zarkadoulia EA, Pliatsika PA, et al. Socioeconomic status (SES) as a determinant of adherence to treatment in HIV infected patients: a systematic review of the literature. Retrovirology. 2008; 5: 13.
3. Ellison-Loschmann L, Sunyer J, Plana E, et al. European Community Respiratory Health Survey. Socioeconomic status, asthma and chronic bronchitis in a large community-based study. Eur Respir J. 2007; 29: 897-905. (Pubitemid 46711893)
4. Bihan H, Laurent S, Sass C, et al. Association among individual deprivation, glycemic control, and diabetes complications: the EPICES score. Diabetes Care. 2005; 28: 2680-2685. (Pubitemid 43951159)
5. Harrison MJ, Tricker KJ, Davies L, et al. The relationship between social deprivation, disease outcome measures, and response to treatment in patients with stable, long-standing rheumatoid arthritis. J Rheumatol. 2005; 32: 2330-2336. (Pubitemid 41782233)
6. Jackson CA, Clatworthy J, Robinson A, et al. Factors associated with non-adherence to oral medication for inflammatory bowel disease: a systematic review. Am J Gastroenterol. 2010; 105: 525-539.
7. Robinson A., Review article: improving adherence to medication in patients with inflammatory bowel disease. Aliment Pharmacol Ther. 2008; 27: 9-14. (Pubitemid 351328756)
8. Lakatos PL,. Prevalence, predictors, and clinical consequences of medical adherence in IBD: how to improve it? World J Gastroenterol. 2009; 15: 4234-4239.
9. Kane SV., Systematic review: adherence issues in the treatment of ulcerative colitis. Aliment Pharmacol Ther. 2006; 23: 577-585.
10. Ediger JP, Walker JR, Graff L, et al. Predictors of medication adherence in inflammatory bowel disease. Am J Gastroenterol. 2007; 102: 1417-1426. (Pubitemid 46976288)
11. D'Inca R, Bertomoro P, Mazzocco K, et al. Risk factors for non-adherence to medication in inflammatory bowel disease patients. Aliment Pharmacol Ther. 2008; 27: 166-172. (Pubitemid 350256604)
12. Sewitch MJ, Abrahamowicz M, Barkun A, et al. Patient nonadherence to medication in inflammatory bowel disease. Am J Gastroenterol. 2003; 98: 1535-1544. (Pubitemid 36875345)
13. Kane S, Huo D, Aikens J, et al. Medication nonadherence and the outcomes of patients with quiescent ulcerative colitis. Am J Med. 2003; 114: 39-43. (Pubitemid 36126514)
14. Cervenà P, Bortlík M, Kubena A, et al. Nonadherence in inflammatory bowel disease: results of factor analysis. Inflamm Bowel Dis. 2007; 13: 1244-1249. (Pubitemid 47597771)
15. Beaugerie L, Seksik P, Nion-Larmurier I, et al. Predictors of Crohn's disease. Gastroenterology. 2006; 130: 650-656. (Pubitemid 43374514)
16. Nahon S, Lahmek P, Macaigne G, et al. Socioeconomic deprivation does not influence the severity of Crohn's disease: results of a prospective multicenter study. Inflamm Bowel Dis. 2009; 15: 594-598.
17. Sass C, Dupré C, Dauphinot V, et al. The EPICES score: an individual index of material and social deprivation related to health status. Part 2: evaluation in a population of 197 389 subjects [article online], 2005. Available from #publis
18. Sass C, Guéguen R, Moulin JJ, et al. Comparison of the individual deprivation index of the French Health Examination Centres and the administrative definition of deprivation. Sante Publique. 2006; 18: 513-522. (Pubitemid 46170327)
19. Guéguen R, Sass C, the EPICES Working Group: The EPICES score: an individual index of material and social deprivation related to health status. Part 1: setting up the score [article online], 2005. Available from
20. Zigmond AS, Snaith RP., The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983; 67: 361-370. (Pubitemid 13098606)
21. Boutron-Ruault MC, Seksik P, Tucat G, et al. Factors associated with nonadherence to medical therapy in inflammatory bowel disease: the totem survey on 1145 patients in France. Gut. 2009; 58 (suppl II): A323.
22. Kane S, Dixon L., Adherence rates with infliximab therapy in Crohn's disease. Aliment Pharmacol Ther. 2006; 24: 1099-1103. (Pubitemid 44386535)
23. Husain A, Triadafilopoulos G., Communicating with patients with inflammatory bowel disease. Inflamm Bowel Dis. 2004; 10: 444-450. (Pubitemid 39029191)
24. Nigro G, Angelini G, Brosso SB, et al. Psychiatric predictors of noncompliance in inflammatory bowel disease. J Clin Gastroenterol. 2001; 32: 66-68. (Pubitemid 32038115)
25. Kane SV., Strategies to improve adherence and outcomes in patients with ulcerative colitis. Drugs. 2008; 68: 2601-2609.
26. Waters BM, Jensen L, Fedorak RN., Effects of formal education for patients with inflammatory bowel disease: a randomized controlled trial. Can J Gastroenterol. 2005; 19: 235-244. (Pubitemid 40778865)