A systems approach to the biology of mood disorders through network analysis of candidate genes

Pharmacopsychiatry

Volumn 44, Issue SUPPL. 1, 2011, Pages

  Detera Wadleigh, S D ^a   Akula, N ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANK3 PROTEIN; APOLIPOPROTEIN E; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BRG1 PROTEIN; BRM PROTEIN; CACNA1C PROTEIN; DISRUPTED IN SCHIZOPHRENIA 1 PROTEIN; GNB3 PROTEIN; MTHFR PROTEIN; NEUROTRANSMITTER; NUCLEOPHOSMIN; PBRM1 PROTEIN; PROTEIN; PYRUVATE DEHYDROGENASE KINASE 4; SEROTONIN TRANSPORTER; SMAD2 PROTEIN; SYNE1 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BRAIN; GENE EXPRESSION; GENE INTERACTION; GENETIC ANALYSIS; GENETIC ASSOCIATION; MOOD DISORDER; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ALGORITHMS; BRAIN; CLUSTER ANALYSIS; COMPUTATIONAL BIOLOGY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; HUMANS; META-ANALYSIS AS TOPIC; MOOD DISORDERS; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; SIGNAL TRANSDUCTION; SOFTWARE;

EID: 79955792243     PISSN: 01763679     EISSN: 14390795     Source Type: Journal    
DOI: 10.1055/s-0031-1275275     Document Type: Article

References (18)

1. Ferreira MA, ODonovan MC, Meng YA et al,. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nat Genet 2008 40 1056-1058
2. McMahon FJ, Akula N, Schulze TG et al,. Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1. Nat Genet 2010 42 128-131
3. Liu Y, Blackwood DH, Caesar S et al,. Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. Mol Psychiatry 2011 16 2-4
4. Wray NR, Pergadia ML, Blackwood DH et al,. Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned. Mol Psychiatry 2010 epub
5. Lopez-Leon S, Janssens AC, Gonzalez-Zuloeta Ladd AM et al,. Meta-analyses of genetic studies on major depressive disorder. Mol Psychiatry 2008 13 772-785 (Pubitemid 352032108)
6. Kim S, Webster MJ. The Stanley Neuropathology Consortium Integrative Database: a novel, web-based tool for exploring neuropathological markers in psychiatric disorders and the biological processes associated with abnormalities of those markers. Neuropsychopharmacology 2010 35 473-482
7. Gupta A, Schulze TG, Nagarajan V et al,. Interaction networks of lithium and valproate molecular targets reveal a striking enrichment of apoptosis functional clusters and neurotrophin signaling. The Pharmacogenomics Journal in press
8. Tarcea VG, Weymouth T, Ade A et al,. Michigan molecular interactions r2: from interacting proteins to pathways. Nucleic Acids Res 2009 37 D642-D646
9. Gao J, Ade AS, Tarcea VG et al,. Integrating and annotating the interactome using the MiMI plugin for cytoscape. Bioinformatics 2009 25 137-138
10. Su G, Kuchinsky A, Morris JH et al,. GLay: community structure analysis of biological networks. Bioinformatics 2010 26 3135-3137
11. Huang da W, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 2009 4 44-57
12. Dennis G Jr, Sherman BT, Hosack DA et al,. DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol 2003 4 P3
13. Green EK, Grozeva D, Jones I et al,. The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia. Mol Psychiatry 2010 15 1016-1022
14. Williams HJ, Craddock N, Russo G et al,. Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries. Hum Mol Genet 2011 20 387-391
15. Dao DT, Mahon PB, Cai X et al,. Mood disorder susceptibility gene CACNA1C modifies mood-related behaviors in mice and interacts with sex to influence behavior in mice and diagnosis in humans. Biol Psychiatry 2010 68 801-810
16. Ho L, Crabtree GR. Chromatin remodelling during development. Nature 2010 463 474-484
17. Klein PS, Melton DA. A molecular mechanism for the effect of lithium on development. Proc Natl Acad Sci USA 1996 93 8455-8459 (Pubitemid 26269579)
18. Koga M, Ishiguro H, Yazaki S et al,. Involvement of SMARCA2/BRM in the SWI/SNF chromatin-remodeling complex in schizophrenia. Hum Mol Genet 2009 18 2483-2494