Assessing vesicoureteral reflux in live inbred mice via ultrasound with a microbubble contrast agent

American Journal of Physiology - Renal Physiology

Volumn 300, Issue 5, 2011, Pages 1262-1265

  Paredes, Jose ^a   Sims Lucas, Sunder ^a   Wang, Hang ^b   Lu, Weining ^b   Coley, Brian ^c   Gittes, George K ^a   Bates, Carlton M ^a,d  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^b Renal Section   (United States)

^c THE RESEARCH INSTITUTE AT NATIONWIDE CHILDREN S HOSPITAL   (United States)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Live cystogram; Mouse

Indexed keywords

CONTRAST MEDIUM;

ANIMAL EXPERIMENT; ARTICLE; C3H MOUSE; CYSTOGRAPHY; FEASIBILITY STUDY; FEMALE; INBRED STRAIN; KIDNEY PELVIS; MICROBUBBLE; MOUSE; NONHUMAN; PRIORITY JOURNAL; ULTRASOUND; URETHRAL CATHETER; VESICOURETERAL REFLUX;

EID: 79955786752     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00720.2010     Document Type: Article

References (26)

1. Anonymous. North American Pediatric Renal Trials and Collaborative Studies: 2010 Annual Report. Rockville, MD: EMMES, 2010, p. 1-100.
2. Bhattacharya A, Dang H, Zhu QM, Schnegelsberg B, Rozengurt N, Cain G, Prantil R, Vorp DA, Guy N, Julius D, Ford AP, Lester HA, Cockayne DA. Uropathic observations in mice expressing a constitutively active point mutation in the 5-HT3A receptor subunit. J Neurosci 24: 5537-5548, 2004.
3. Chand DH, Rhoades T, Poe SA, Kraus S, Strife CF. Incidence and severity of vesicoureteral reflux in children related to age, gender, race and diagnosis. J Urol 170: 1548-1550, 2003.
4. Cockayne DA, Hamilton SG, Zhu QM, Dunn PM, Zhong Y, Novakovic S, Malmberg AB, Cain G, Berson A, Kassotakis L, Hedley L, Lachnit WG, Burnstock G, McMahon SB, Ford AP. Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice. Nature 407: 1011-1015, 2000.
5. Cooper CS. Diagnosis and management of vesicoureteral reflux in children. Nat Rev Urol 6: 481-489, 2009.
6. Darge K. Voiding urosonography with US contrast agent for the diagnosis of vesicoureteric reflux in children: an update. Pediatr Radiol 40: 956-962, 2010.
7. Darge K. Voiding urosonography with US contrast agents for the diagnosis of vesicoureteric reflux in children. II. Comparison with radiological examinations. Pediatr Radiol 38: 54-63, 2008.
8. Hains DS, Sims-Lucas S, Carpenter A, Saha M, Murawski I, Kish K, Gupta I, McHugh K, Bates CM. High incidence of vesicoureteral reflux in mice with Fgfr2 deletion in kidney mesenchyma. J Urol 183: 2077-2084, 2010.
9. Kessler RM, Altman DH. Real-time sonographic detection of vesicoureteral reflux in children. AJR Am J Roentgenol 138: 1033-1036, 1982.
10. Kis E, Nyitrai A, Varkonyi I, Mattyus I, Cseprekal O, Reusz G, Szabo A. Voiding urosonography with second-generation contrast agent versus voiding cystourethrography. Pediatr Nephrol 25: 2289-2293, 2010.
11. Lebowitz RL. The detection and characterization of vesicoureteral reflux in the child. J Urol 148: 1640-1642, 1992.
12. Lu W, van Eerde AM, Fan X, Quintero-Rivera F, Kulkarni S, Ferguson H, Kim HG, Fan Y, Xi Q, Li QG, Sanlaville D, Andrews W, Sundaresan V, Bi W, Yan J, Giltay JC, Wijmenga C, de Jong TP, Feather SA, Woolf AS, Rao Y, Lupski JR, Eccles MR, Quade BJ, Gusella JF, Morton CC, Maas RL. Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux. Am J Hum Genet 80: 616-632, 2007.
13. Mak RH, Kuo HJ. Primary ureteral reflux: emerging insights from molecular and genetic studies. Curr Opin Pediatr 15: 181-185, 2003.
14. Murawski IJ, Gupta IR. Gene discovery and vesicoureteric reflux. Pediatr Nephrol 23: 1021-1027, 2008.
15. Murawski IJ, Gupta IR. Vesicoureteric reflux and renal malformations: a developmental problem. Clin Genet 69: 105-117, 2006.
16. Murawski IJ, Maina RW, Malo D, Guay-Woodford LM, Gros P, Fujiwara M, Morgan K, Gupta IR. The C3H/HeJ inbred mouse is a model of vesico-ureteric reflux with a susceptibility locus on chromosome 12. Kidney Int 78: 269-278, 2010.
17. Murawski IJ, Myburgh DB, Favor J, Gupta IR. Vesicoureteric reflux and urinary tract development in the Pax2 1Neu+/- mouse. Am J Physiol Renal Physiol 293: F1736-F1745, 2007.
18. Needles A, Arditi M, Rognin NG, Mehi J, Coulthard T, Bilan-Tracey C, Gaud E, Frinking P, Hirson D, Foster FS. Nonlinear contrast imaging with an array-based micro-ultrasound system. Ultrasound Med Biol 36: 2097-2106, 2010.
19. Oswald J, Brenner E, Schwentner C, Deibl M, Bartsch G, Fritsch H, Radmayr C. The intravesical ureter in children with vesicoureteral reflux: a morphological and immunohistochemical characterization. J Urol 170: 2423-2427, 2003.
20. Oswald J, Schwentner C, Brenner E, Deibl M, Fritsch H, Bartsch G, Radmayr C. Extracellular matrix degradation and reduced nerve supply in refluxing ureteral endings. J Urol 172: 1099-1102, 2004.
21. Riccabona M, Mache CJ, Lindbichler F. Echo-enhanced color Doppler cystosonography of vesicoureteral reflux in children. Improvement by stimulated acoustic emission. Acta Radiol 44: 18-23, 2003.
22. Rossleigh MA. Renal infection and vesico-ureteric reflux. Semin Nucl Med 37: 261-268, 2007.
23. Schwentner C, Oswald J, Lunacek A, Fritsch H, Deibl M, Bartsch G, Radmayr C. Loss of interstitial cells of Cajal and gap junction protein connexin 43 at the vesicoureteral junction in children with vesicoureteral reflux. J Urol 174: 1981-1986, 2005.
24. Silva JM, Oliveira EA, Diniz JS, Cardoso LS, Vergara RM, Vasconcelos MA, Santo DE. Gender and vesico-ureteral reflux: a multivariate analysis. Pediatr Nephrol 21: 510-516, 2006.
25. Valentini AL, De Gaetano AM, Minordi LM, Nanni G, Citterio F, Viggiano AM, Tancioni V, Destito C. Contrast-enhanced voiding US for grading of reflux in adult patients prior to antireflux ureteral implantation. Radiology 233: 35-39, 2004.
26. Zimbaro G, Ascenti G, Visalli C, Bottari A, Zimbaro F, Martino N, Mazziotti S. Contrast-enhanced ultrasonography (voiding urosonography) of vesicoureteral reflux: state of the art. Radiol Med 112: 1211-1224, 2007.