메뉴 건너뛰기




Volumn 6, Issue 5, 2011, Pages

Fosmidomycin uptake into Plasmodium and Babesia-infected erythrocytes is facilitated by parasite-induced new permeability pathways

Author keywords

[No Author keywords available]

Indexed keywords

3 [ACETYL(HYDROXY)AMINO]PROPYLPHOSPHONIC ACID; ANTIPROTOZOAL AGENT; CID 162204; CID 572; FOSMIDOMYCIN; ISOPRENOID; OXIDOREDUCTASE; UNCLASSIFIED DRUG; ANTIMALARIAL AGENT; DRUG DERIVATIVE; FOSFOMYCIN;

EID: 79955781059     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0019334     Document Type: Article
Times cited : (75)

References (74)
  • 1
    • 0033520336 scopus 로고    scopus 로고
    • Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs
    • Jomaa H, Wiesner J, Sanderbrand S, Altincicek B, Weidemeyer C, et al. (1999) Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. Science 285: 1573-1576.
    • (1999) Science , vol.285 , pp. 1573-1576
    • Jomaa, H.1    Wiesner, J.2    Sanderbrand, S.3    Altincicek, B.4    Weidemeyer, C.5
  • 2
    • 10644295471 scopus 로고    scopus 로고
    • The methylerythritol phosphate pathway is functionally active in all intraerythrocytic stages of Plasmodium falciparum
    • Cassera M, Gozzo F, D'alexandri F, Merino E, Del Portillo H, et al. (2004) The methylerythritol phosphate pathway is functionally active in all intraerythrocytic stages of Plasmodium falciparum. J Biol Chem 279: 51749-51759.
    • (2004) J Biol Chem , vol.279 , pp. 51749-51759
    • Cassera, M.1    Gozzo, F.2    D'alexandri, F.3    Merino, E.4    del Portillo, H.5
  • 3
    • 74849090103 scopus 로고    scopus 로고
    • Functional genetic analysis of the Plasmodium falciparum deoxyxylulose 5-phosphate reductoisomerase gene
    • Odom AR, Van Voorhis WC, (2010) Functional genetic analysis of the Plasmodium falciparum deoxyxylulose 5-phosphate reductoisomerase gene. Mol Biochem Parasitol 170: 108-111.
    • (2010) Mol Biochem Parasitol , vol.170 , pp. 108-111
    • Odom, A.R.1    van Voorhis, W.C.2
  • 4
    • 12144289864 scopus 로고    scopus 로고
    • Fosmidomycin-clindamycin for Plasmodium falciparum infections in african children
    • Borrmann S, Adegnika AA, Matsiegui PB, Issifou S, Schindler A, et al. (2004) Fosmidomycin-clindamycin for Plasmodium falciparum infections in african children. J Infect Dis 189: 901-908.
    • (2004) J Infect Dis , vol.189 , pp. 901-908
    • Borrmann, S.1    Adegnika, A.A.2    Matsiegui, P.B.3    Issifou, S.4    Schindler, A.5
  • 5
    • 24144461306 scopus 로고    scopus 로고
    • Short-course regimens of artesunate-fosmidomycin in treatment of uncomplicated Plasmodium falciparum malaria
    • Borrmann S, Adegnika AA, Moussavou F, Oyakhirome S, Esser G, et al. (2005) Short-course regimens of artesunate-fosmidomycin in treatment of uncomplicated Plasmodium falciparum malaria. Antimicrob Agents Chemother 49: 3749-3754.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 3749-3754
    • Borrmann, S.1    Adegnika, A.A.2    Moussavou, F.3    Oyakhirome, S.4    Esser, G.5
  • 6
    • 33746912371 scopus 로고    scopus 로고
    • Fosmidomycin plus clindamycin for treatment of pediatric patients aged 1 to 14 years with Plasmodium falciparum malaria
    • Borrmann S, Lundgren I, Oyakhirome S, Impouma B, Matsiegui PB, et al. (2006) Fosmidomycin plus clindamycin for treatment of pediatric patients aged 1 to 14 years with Plasmodium falciparum malaria. Antimicrob Agents Chemother 50: 2713-2718.
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 2713-2718
    • Borrmann, S.1    Lundgren, I.2    Oyakhirome, S.3    Impouma, B.4    Matsiegui, P.B.5
  • 8
    • 67349124872 scopus 로고    scopus 로고
    • The global portfolio of new antimalarial medicines under development
    • Olliaro P, Wells T, (2009) The global portfolio of new antimalarial medicines under development. Clinl Pharmacol Ther 85: 584-595.
    • (2009) Clinl Pharmacol Ther , vol.85 , pp. 584-595
    • Olliaro, P.1    Wells, T.2
  • 9
    • 0021932270 scopus 로고
    • Fosmidomycin, a new phosphonic acid antibiotic. Part II: 1. Human pharmacokinetics. 2. Preliminary early phase IIa clinical studies
    • Kuemmerle HP, Murakawa T, Sakamoto H, Sato N, Konishi T, et al. (1985) Fosmidomycin, a new phosphonic acid antibiotic. Part II: 1. Human pharmacokinetics. 2. Preliminary early phase IIa clinical studies. Int J Clin Pharmacol Ther Toxicol 23: 521-528.
    • (1985) Int J Clin Pharmacol Ther Toxicol , vol.23 , pp. 521-528
    • Kuemmerle, H.P.1    Murakawa, T.2    Sakamoto, H.3    Sato, N.4    Konishi, T.5
  • 10
    • 77949568358 scopus 로고    scopus 로고
    • Artemisinin resistance: current status and scenarios for containment
    • Dondorp AM, Yeung S, White L, Nguon C, Day NP, et al. (2010) Artemisinin resistance: current status and scenarios for containment. Nat Rev Microbiol 8: 272-280.
    • (2010) Nat Rev Microbiol , vol.8 , pp. 272-280
    • Dondorp, A.M.1    Yeung, S.2    White, L.3    Nguon, C.4    Day, N.P.5
  • 11
    • 3242785011 scopus 로고    scopus 로고
    • Isoprenoids: remarkable diversity of form and function
    • Holstein SA, Hohl RJ, (2004) Isoprenoids: remarkable diversity of form and function. Lipids 39: 293-309.
    • (2004) Lipids , vol.39 , pp. 293-309
    • Holstein, S.A.1    Hohl, R.J.2
  • 12
  • 13
    • 77955907263 scopus 로고    scopus 로고
    • Metabolic pathways in the apicoplast of apicomplexa
    • Seeber F, Soldati-Favre D, (2010) Metabolic pathways in the apicoplast of apicomplexa. Int Rev Cell Mol Biol 281: 161-228.
    • (2010) Int Rev Cell Mol Biol , vol.281 , pp. 161-228
    • Seeber, F.1    Soldati-Favre, D.2
  • 14
    • 34249881089 scopus 로고    scopus 로고
    • The methylerythritol phosphate pathway for isoprenoid biosynthesis in coccidia: Presence and sensitivity to fosmidomycin
    • Clastre M, Goubard A, Prel A, Mincheva Z, Viaudmassuart M, et al. (2007) The methylerythritol phosphate pathway for isoprenoid biosynthesis in coccidia: Presence and sensitivity to fosmidomycin. Exp Parasitol 116: 375-384.
    • (2007) Exp Parasitol , vol.116 , pp. 375-384
    • Clastre, M.1    Goubard, A.2    Prel, A.3    Mincheva, Z.4    Viaudmassuart, M.5
  • 16
    • 18244410156 scopus 로고    scopus 로고
    • Bisphosphonate inhibitors of Toxoplasma gondi growth: in vitro, QSAR, and in vivo investigations
    • Ling Y, Sahota G, Odeh S, Chan JM, Araujo FG, et al. (2005) Bisphosphonate inhibitors of Toxoplasma gondi growth: in vitro, QSAR, and in vivo investigations. J Med Chem 48: 3130-3140.
    • (2005) J Med Chem , vol.48 , pp. 3130-3140
    • Ling, Y.1    Sahota, G.2    Odeh, S.3    Chan, J.M.4    Araujo, F.G.5
  • 17
    • 0035069258 scopus 로고    scopus 로고
    • Membrane transport in the malaria-infected erythrocyte
    • Kirk K, (2001) Membrane transport in the malaria-infected erythrocyte. Physiol Rev 81: 495-537.
    • (2001) Physiol Rev , vol.81 , pp. 495-537
    • Kirk, K.1
  • 18
    • 0032524378 scopus 로고    scopus 로고
    • Structural selectivity and molecular nature of L-glutamate transport in cultured human fibroblasts
    • Cooper B, Chebib M, Shen J, King NJC, Darvey IG, et al. (1998) Structural selectivity and molecular nature of L-glutamate transport in cultured human fibroblasts. Arch Biochem Biophys 353: 356-364.
    • (1998) Arch Biochem Biophys , vol.353 , pp. 356-364
    • Cooper, B.1    Chebib, M.2    Shen, J.3    King, N.J.C.4    Darvey, I.G.5
  • 19
    • 33846820032 scopus 로고    scopus 로고
    • Infection with Toxoplasma gondii bradyzoites has a diminished impact on host transcript levels relative to tachyzoite infection
    • Fouts AE, Boothroyd JC, (2007) Infection with Toxoplasma gondii bradyzoites has a diminished impact on host transcript levels relative to tachyzoite infection. Infect Immun 75: 634-642.
    • (2007) Infect Immun , vol.75 , pp. 634-642
    • Fouts, A.E.1    Boothroyd, J.C.2
  • 20
    • 33645285279 scopus 로고    scopus 로고
    • Evidence for the involvement of Plasmodium falciparum proteins in the formation of new permeability pathways in the erythrocyte membrane
    • Baumeister S, Winterberg M, Duranton C, Huber S, Lang F, et al. (2006) Evidence for the involvement of Plasmodium falciparum proteins in the formation of new permeability pathways in the erythrocyte membrane. Mol Microbiol 60: 493-504.
    • (2006) Mol Microbiol , vol.60 , pp. 493-504
    • Baumeister, S.1    Winterberg, M.2    Duranton, C.3    Huber, S.4    Lang, F.5
  • 21
    • 0142187146 scopus 로고    scopus 로고
    • Babesia divergens, a bovine blood parasite of veterinary and zoonotic importance
    • Zintl A, Mulcahy G, Skerrett H, Taylor S, Gray J, (2003) Babesia divergens, a bovine blood parasite of veterinary and zoonotic importance. Clin Microbiol Rev 16: 622-636.
    • (2003) Clin Microbiol Rev , vol.16 , pp. 622-636
    • Zintl, A.1    Mulcahy, G.2    Skerrett, H.3    Taylor, S.4    Gray, J.5
  • 22
    • 33947136307 scopus 로고    scopus 로고
    • Babesia and plasmodia increase host erythrocyte permeability through distinct mechanisms
    • Alkhalil A, Hill D, Desai S, (2007) Babesia and plasmodia increase host erythrocyte permeability through distinct mechanisms. Cell Microbiol 9: 851-860.
    • (2007) Cell Microbiol , vol.9 , pp. 851-860
    • Alkhalil, A.1    Hill, D.2    Desai, S.3
  • 23
    • 77957922344 scopus 로고    scopus 로고
    • In vitro inhibitory effect of fosmidomycin on the asexual growth of Babesia bovis and Babesia bigemina
    • Sivakumar T, Aboulaila M, Khukhuu A, Iseki H, Alhassan A, et al. (2008) In vitro inhibitory effect of fosmidomycin on the asexual growth of Babesia bovis and Babesia bigemina. J Protozool Res 18: 71-78.
    • (2008) J Protozool Res , vol.18 , pp. 71-78
    • Sivakumar, T.1    Aboulaila, M.2    Khukhuu, A.3    Iseki, H.4    Alhassan, A.5
  • 27
    • 28844484972 scopus 로고    scopus 로고
    • 1-Deoxy-d-xylulose 5-phosphate reductoisomerase (IspC) from Mycobacterium tuberculosis: towards understanding mycobacterial resistance to fosmidomycin
    • Dhiman RK, Schaeffer ML, Bailey AM, Testa CA, Scherman H, et al. (2005) 1-Deoxy-d-xylulose 5-phosphate reductoisomerase (IspC) from Mycobacterium tuberculosis: towards understanding mycobacterial resistance to fosmidomycin. J Bacteriol 187: 8395-8402.
    • (2005) J Bacteriol , vol.187 , pp. 8395-8402
    • Dhiman, R.K.1    Schaeffer, M.L.2    Bailey, A.M.3    Testa, C.A.4    Scherman, H.5
  • 28
    • 0036724815 scopus 로고    scopus 로고
    • Isoprenoid biosynthesis in Synechocystis sp. strain PCC6803 is stimulated by compounds of the pentose phosphate cycle but not by pyruvate or deoxyxylulose-5-phosphate
    • Ershov Y, Gantt R, Cunningham FX, Gantt E, (2002) Isoprenoid biosynthesis in Synechocystis sp. strain PCC6803 is stimulated by compounds of the pentose phosphate cycle but not by pyruvate or deoxyxylulose-5-phosphate. J Bacteriol 184: 5045-5051.
    • (2002) J Bacteriol , vol.184 , pp. 5045-5051
    • Ershov, Y.1    Gantt, R.2    Cunningham, F.X.3    Gantt, E.4
  • 29
    • 32844461335 scopus 로고    scopus 로고
    • Evaluation of fosmidomycin analogs as inhibitors of the Synechocystis sp. PCC6803 1-deoxy-D-xylulose 5-phosphate reductoisomerase
    • Woo Y-H, Fernandes RPM, Proteau PJ, (2006) Evaluation of fosmidomycin analogs as inhibitors of the Synechocystis sp. PCC6803 1-deoxy-D-xylulose 5-phosphate reductoisomerase. Bioorg Med Chem 14: 2375-2385.
    • (2006) Bioorg Med Chem , vol.14 , pp. 2375-2385
    • Woo, Y.-H.1    Fernandes, R.P.M.2    Proteau, P.J.3
  • 30
    • 44849135047 scopus 로고    scopus 로고
    • Dxr is essential in Mycobacterium tuberculosis and fosmidomycin resistance is due to a lack of uptake
    • Brown A, Parish T, (2008) Dxr is essential in Mycobacterium tuberculosis and fosmidomycin resistance is due to a lack of uptake. BMC Microbiol 8: 78.
    • (2008) BMC Microbiol , vol.8 , pp. 78
    • Brown, A.1    Parish, T.2
  • 31
    • 2842613801 scopus 로고    scopus 로고
    • Fosmidomycin resistance in adenylate cyclase deficient (cya) mutants of Escherichia coli
    • Sakamoto Y, Furukawa S, Ogihara H, Yamasaki M, (2003) Fosmidomycin resistance in adenylate cyclase deficient (cya) mutants of Escherichia coli. Biosci Biotechnol Biochem 67: 2030-2033.
    • (2003) Biosci Biotechnol Biochem , vol.67 , pp. 2030-2033
    • Sakamoto, Y.1    Furukawa, S.2    Ogihara, H.3    Yamasaki, M.4
  • 32
    • 77956282463 scopus 로고    scopus 로고
    • A new family of enzymes catalyzing the first committed step of the methylerythritol 4-phosphate (MEP) pathway for isoprenoid biosynthesis in bacteria
    • Sangari FJ, Perez-Gil J, Carretero-Paulet L, Garcia-Lobo JM, Rodriguez-Concepcion M, (2010) A new family of enzymes catalyzing the first committed step of the methylerythritol 4-phosphate (MEP) pathway for isoprenoid biosynthesis in bacteria. Proc Natl Acad Sci USA 107: 14081-14086.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 14081-14086
    • Sangari, F.J.1    Perez-Gil, J.2    Carretero-Paulet, L.3    Garcia-Lobo, J.M.4    Rodriguez-Concepcion, M.5
  • 33
    • 33845717210 scopus 로고    scopus 로고
    • The expression of a plant-type ferredoxin redox system provides molecular evidence for a plastid in the early dinoflagellate Perkinsus marinus
    • Stelter K, El-Sayed NM, Seeber F, (2007) The expression of a plant-type ferredoxin redox system provides molecular evidence for a plastid in the early dinoflagellate Perkinsus marinus. Protist 158: 119-130.
    • (2007) Protist , vol.158 , pp. 119-130
    • Stelter, K.1    El-Sayed, N.M.2    Seeber, F.3
  • 34
    • 37549066871 scopus 로고    scopus 로고
    • Plastid isoprenoid metabolism in the oyster parasite Perkinsus marinus connects dinoflagellates and malaria pathogens-new impetus for studying alveolates
    • Grauvogel C, Reece KS, Brinkmann H, Petersen J, (2007) Plastid isoprenoid metabolism in the oyster parasite Perkinsus marinus connects dinoflagellates and malaria pathogens-new impetus for studying alveolates. J Mol Evol 65: 725-729.
    • (2007) J Mol Evol , vol.65 , pp. 725-729
    • Grauvogel, C.1    Reece, K.S.2    Brinkmann, H.3    Petersen, J.4
  • 35
    • 70350712751 scopus 로고    scopus 로고
    • Plasmodium berghei-infection induces volume-regulated anion channel-like activity in human hepatoma cells
    • Prudencio M, Derbyshire ET, Marques CA, Krishna S, Mota MM, et al. (2009) Plasmodium berghei-infection induces volume-regulated anion channel-like activity in human hepatoma cells. Cell Microbiol 11: 1492-1501.
    • (2009) Cell Microbiol , vol.11 , pp. 1492-1501
    • Prudencio, M.1    Derbyshire, E.T.2    Marques, C.A.3    Krishna, S.4    Mota, M.M.5
  • 36
    • 77949539756 scopus 로고    scopus 로고
    • The malaria parasite Plasmodium falciparum: cell biological peculiarities and nutritional consequences
    • Baumeister S, Winterberg M, Przyborski J, Lingelbach K, (2010) The malaria parasite Plasmodium falciparum: cell biological peculiarities and nutritional consequences. Protoplasma 240: 3-12.
    • (2010) Protoplasma , vol.240 , pp. 3-12
    • Baumeister, S.1    Winterberg, M.2    Przyborski, J.3    Lingelbach, K.4
  • 37
    • 33947158084 scopus 로고    scopus 로고
    • Electrophysiological studies of malaria parasite-infected erythrocytes: current status
    • Staines HM, Alkhalil A, Allen RJ, De Jonge HR, Derbyshire E, et al. (2007) Electrophysiological studies of malaria parasite-infected erythrocytes: current status. Int J Parasitol 37: 475-482.
    • (2007) Int J Parasitol , vol.37 , pp. 475-482
    • Staines, H.M.1    Alkhalil, A.2    Allen, R.J.3    de Jonge, H.R.4    Derbyshire, E.5
  • 38
    • 0035037590 scopus 로고    scopus 로고
    • Diamidine compounds: selective uptake and targeting in Plasmodium falciparum
    • Stead AMW, Bray PG, Edwards IG, Dekoning HP, Elford BC, et al. (2001) Diamidine compounds: selective uptake and targeting in Plasmodium falciparum. Mol Pharmacol 59: 1298-1306.
    • (2001) Mol Pharmacol , vol.59 , pp. 1298-1306
    • Stead, A.M.W.1    Bray, P.G.2    Edwards, I.G.3    Dekoning, H.P.4    Elford, B.C.5
  • 39
  • 40
    • 0023356849 scopus 로고
    • New permeability pathways induced by the malarial parasite in the membrane of its host erythrocyte: potential routes for targeting of drugs into infected cells
    • Ginsburg H, Stein WD, (1987) New permeability pathways induced by the malarial parasite in the membrane of its host erythrocyte: potential routes for targeting of drugs into infected cells. Biosci Rep 7: 455-463.
    • (1987) Biosci Rep , vol.7 , pp. 455-463
    • Ginsburg, H.1    Stein, W.D.2
  • 41
    • 12744253952 scopus 로고    scopus 로고
    • The new permeability pathways: targets and selective routes for the development of new antimalarial agents
    • Staines HM, Ellory JC, Chibale K, (2005) The new permeability pathways: targets and selective routes for the development of new antimalarial agents. Comb Chem High Through Screen 8: 81-88.
    • (2005) Comb Chem High Through Screen , vol.8 , pp. 81-88
    • Staines, H.M.1    Ellory, J.C.2    Chibale, K.3
  • 42
    • 0037240521 scopus 로고    scopus 로고
    • New malaria chemotherapy developed by utilization of a unique parasite transport system
    • Gero AM, Dunn CG, Brown DM, Pulenthiran K, Gorovits EL, et al. (2003) New malaria chemotherapy developed by utilization of a unique parasite transport system. Curr Pharm Des 9: 867-877.
    • (2003) Curr Pharm Des , vol.9 , pp. 867-877
    • Gero, A.M.1    Dunn, C.G.2    Brown, D.M.3    Pulenthiran, K.4    Gorovits, E.L.5
  • 43
    • 33846518982 scopus 로고    scopus 로고
    • A blasticidin S-resistant Plasmodium falciparum mutant with a defective plasmodial surface anion channel
    • Hill D, Pillai AD, Nawaz F, Hayton K, Doan L, et al. (2007) A blasticidin S-resistant Plasmodium falciparum mutant with a defective plasmodial surface anion channel. Proc Natl Acad Sci USA 104: 1063-1068.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 1063-1068
    • Hill, D.1    Pillai, A.D.2    Nawaz, F.3    Hayton, K.4    Doan, L.5
  • 44
    • 46249107664 scopus 로고    scopus 로고
    • Changes in the plasmodial surface anion channel reduce leupeptin uptake and can confer drug resistance in Plasmodium falciparum-infected erythrocytes
    • Lisk G, Pain M, Gluzman IY, Kambhampati S, Furuya T, et al. (2008) Changes in the plasmodial surface anion channel reduce leupeptin uptake and can confer drug resistance in Plasmodium falciparum-infected erythrocytes. Antimicrob Agents Chemother 52: 2346-2354.
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 2346-2354
    • Lisk, G.1    Pain, M.2    Gluzman, I.Y.3    Kambhampati, S.4    Furuya, T.5
  • 45
    • 62549103382 scopus 로고    scopus 로고
    • Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum
    • Dharia NV, Sidhu AB, Cassera MB, Westenberger SJ, Bopp SE, et al. (2009) Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum. Genome Biol 10: R21.
    • (2009) Genome Biol , vol.10
    • Dharia, N.V.1    Sidhu, A.B.2    Cassera, M.B.3    Westenberger, S.J.4    Bopp, S.E.5
  • 46
    • 0033962141 scopus 로고    scopus 로고
    • Increased permeability of the malaria-infected erythrocyte to organic cations
    • Staines HM, Rae C, Kirk K, (2000) Increased permeability of the malaria-infected erythrocyte to organic cations. Biochim Biophys Acta 1463: 88-98.
    • (2000) Biochim Biophys Acta , vol.1463 , pp. 88-98
    • Staines, H.M.1    Rae, C.2    Kirk, K.3
  • 47
    • 58149128997 scopus 로고    scopus 로고
    • Metabolite-likeness' as a criterion in the design and selection of pharmaceutical drug libraries
    • Dobson PD, Patel Y, Kell DB, (2009) 'Metabolite-likeness' as a criterion in the design and selection of pharmaceutical drug libraries. Drug Discov Today 14: 31-40.
    • (2009) Drug Discov Today , vol.14 , pp. 31-40
    • Dobson, P.D.1    Patel, Y.2    Kell, D.B.3
  • 48
    • 40049110714 scopus 로고    scopus 로고
    • Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?
    • Dobson PD, Kell DB, (2008) Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule? Nat Rev Drug Discov 7: 205-220.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 205-220
    • Dobson, P.D.1    Kell, D.B.2
  • 49
    • 77952704258 scopus 로고    scopus 로고
    • Thousands of chemical starting points for antimalarial lead identification
    • Gamo FJ, Sanz LM, Vidal J, de Cozar C, Alvarez E, et al. (2010) Thousands of chemical starting points for antimalarial lead identification. Nature 465: 305-310.
    • (2010) Nature , vol.465 , pp. 305-310
    • Gamo, F.J.1    Sanz, L.M.2    Vidal, J.3    de Cozar, C.4    Alvarez, E.5
  • 50
    • 76749095030 scopus 로고    scopus 로고
    • Next-generation antimalarial drugs: hybrid molecules as a new strategy in drug design
    • Muregi FW, Ishih A, (2010) Next-generation antimalarial drugs: hybrid molecules as a new strategy in drug design. Drug Develop Res 71: 20-32.
    • (2010) Drug Develop Res , vol.71 , pp. 20-32
    • Muregi, F.W.1    Ishih, A.2
  • 51
    • 71049170515 scopus 로고    scopus 로고
    • Coordination chemistry based approach to lipophilic inhibitors of 1-deoxy-D-xylulose-5-phosphate reductoisomerase
    • Deng L, Sundriyal S, Rubio V, Shi Z-z, Song Y, (2009) Coordination chemistry based approach to lipophilic inhibitors of 1-deoxy-D-xylulose-5-phosphate reductoisomerase. J Med Chem 52: 6539-6542.
    • (2009) J Med Chem , vol.52 , pp. 6539-6542
    • Deng, L.1    Sundriyal, S.2    Rubio, V.3    Shi, Z.-Z.4    Song, Y.5
  • 52
    • 37349115214 scopus 로고    scopus 로고
    • Double ester prodrugs of FR900098 display enhanced in-vitro antimalarial activity
    • Wiesner J, Ortmann R, Jomaa H, Schlitzer M, (2007) Double ester prodrugs of FR900098 display enhanced in-vitro antimalarial activity. Arch Pharm Chem Life Sci 340: 667-669.
    • (2007) Arch Pharm Chem Life Sci , vol.340 , pp. 667-669
    • Wiesner, J.1    Ortmann, R.2    Jomaa, H.3    Schlitzer, M.4
  • 53
    • 77954921896 scopus 로고    scopus 로고
    • Organometallic mechanism of action and inhibition of the 4Fe-4S isoprenoid biosynthesis protein GcpE (IspG)
    • Wang W, Li J, Wang K, Huang C, Zhang Y, et al. (2010) Organometallic mechanism of action and inhibition of the 4Fe-4S isoprenoid biosynthesis protein GcpE (IspG). Proc Natl Acad Sci USA 107: 11189-11193.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 11189-11193
    • Wang, W.1    Li, J.2    Wang, K.3    Huang, C.4    Zhang, Y.5
  • 54
    • 77949510795 scopus 로고    scopus 로고
    • Bioorganometallic mechanism of action, and inhibition, of IspH
    • Wang W, Wang K, Liu YL, No JH, Li J, et al. (2010) Bioorganometallic mechanism of action, and inhibition, of IspH. Proc Natl Acad Sci USA 107: 4522-4527.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 4522-4527
    • Wang, W.1    Wang, K.2    Liu, Y.L.3    No, J.H.4    Li, J.5
  • 55
    • 33747261256 scopus 로고
    • Hydroxyaminohydrocarbon-phosphonic acids
    • US patent 4,206
    • Kamiya T, Hashimoto M, Hemmi K, Takeno H, (1980) Hydroxyaminohydrocarbon-phosphonic acids. 156 US patent 4,206.
    • (1980) , vol.156
    • Kamiya, T.1    Hashimoto, M.2    Hemmi, K.3    Takeno, H.4
  • 56
    • 0029027282 scopus 로고
    • Regioselective palladium(0) catalyzed amination of carbonates of allylic hydroxyphosphonates with hydroxylamine derivatives: A convenient route to phosphonic acids related to the antibiotic fosmidomycin
    • Öhler E, Kanzler S, (1995) Regioselective palladium(0) catalyzed amination of carbonates of allylic hydroxyphosphonates with hydroxylamine derivatives: A convenient route to phosphonic acids related to the antibiotic fosmidomycin. Synthesis 1995: 539-543.
    • (1995) Synthesis , vol.1995 , pp. 539-543
    • Öhler, E.1    Kanzler, S.2
  • 57
    • 0017311840 scopus 로고
    • Human malaria parasites in continuous culture
    • Trager W, Jensen JB, (1976) Human malaria parasites in continuous culture. Science 193: 673-675.
    • (1976) Science , vol.193 , pp. 673-675
    • Trager, W.1    Jensen, J.B.2
  • 58
    • 0018704491 scopus 로고
    • Synchronization of Plasmodium falciparum erythrocytic stages in culture
    • Lambros C, Vanderberg JP, (1979) Synchronization of Plasmodium falciparum erythrocytic stages in culture. J Parasitol 65: 418-420.
    • (1979) J Parasitol , vol.65 , pp. 418-420
    • Lambros, C.1    van der Berg, J.P.2
  • 59
    • 0018249537 scopus 로고
    • Separation of viable schizont-infected red cells of Plasmodium falciparum from human blood
    • Pasvol G, Wilson RJ, Smalley ME, Brown J, (1978) Separation of viable schizont-infected red cells of Plasmodium falciparum from human blood. Ann Trop Med Parasitol 72: 87-88.
    • (1978) Ann Trop Med Parasitol , vol.72 , pp. 87-88
    • Pasvol, G.1    Wilson, R.J.2    Smalley, M.E.3    Brown, J.4
  • 60
    • 0029670076 scopus 로고    scopus 로고
    • Escherichia coli beta-galactosidase as an in vitro and in vivo reporter enzyme and stable transfection marker in the intracellular protozoan parasite Toxoplasma gondii
    • Seeber F, Boothroyd JC, (1996) Escherichia coli beta-galactosidase as an in vitro and in vivo reporter enzyme and stable transfection marker in the intracellular protozoan parasite Toxoplasma gondii. Gene 169: 39-45.
    • (1996) Gene , vol.169 , pp. 39-45
    • Seeber, F.1    Boothroyd, J.C.2
  • 61
    • 0026020595 scopus 로고
    • Cytological and immunological responses to Babesia divergens in different hosts: ox, gerbil, man
    • Gorenflot A, Brasseur P, Precigout E, L'Hostis M, Marchand A, et al. (1991) Cytological and immunological responses to Babesia divergens in different hosts: ox, gerbil, man. Parasitol Res 77: 3-12.
    • (1991) Parasitol Res , vol.77 , pp. 3-12
    • Gorenflot, A.1    Brasseur, P.2    Precigout, E.3    L'Hostis, M.4    Marchand, A.5
  • 62
    • 45549085673 scopus 로고    scopus 로고
    • Towards new antimalarial drugs: synthesis of non-hydrolyzable phosphate mimics as feed for a predictive QSAR study on 1-deoxy-D-xylulose-5-phosphate reductoisomerase inhibitors
    • Giessmann D, Heidler P, Haemers T, Van Calenbergh S, Reichenberg A, et al. (2008) Towards new antimalarial drugs: synthesis of non-hydrolyzable phosphate mimics as feed for a predictive QSAR study on 1-deoxy-D-xylulose-5-phosphate reductoisomerase inhibitors. Chem Biodivers 5: 643-656.
    • (2008) Chem Biodivers , vol.5 , pp. 643-656
    • Giessmann, D.1    Heidler, P.2    Haemers, T.3    van Calenbergh, S.4    Reichenberg, A.5
  • 63
    • 2942631511 scopus 로고    scopus 로고
    • Multiple functionally redundant signals mediate targeting to the apicoplast in the apicomplexan parasite Toxoplasma gondii
    • Harb OS, Chatterjee B, Fraunholz MJ, Crawford MJ, Nishi M, et al. (2004) Multiple functionally redundant signals mediate targeting to the apicoplast in the apicomplexan parasite Toxoplasma gondii. Eukaryot Cell 3: 663-674.
    • (2004) Eukaryot Cell , vol.3 , pp. 663-674
    • Harb, O.S.1    Chatterjee, B.2    Fraunholz, M.J.3    Crawford, M.J.4    Nishi, M.5
  • 65
    • 0035798694 scopus 로고    scopus 로고
    • The loss of cytoplasmic potassium upon host cell breakdown triggers egress of Toxoplasma gondii
    • Moudy R, Manning TJ, Beckers CJ, (2001) The loss of cytoplasmic potassium upon host cell breakdown triggers egress of Toxoplasma gondii. J Biol Chem 276: 41492-41501.
    • (2001) J Biol Chem , vol.276 , pp. 41492-41501
    • Moudy, R.1    Manning, T.J.2    Beckers, C.J.3
  • 66
    • 0034522796 scopus 로고    scopus 로고
    • Plasmodium falciparum: Detection of the deoxyxylulose 5-phosphate reductoisomerase activity
    • Wiesner J, Hintz M, Altincicek B, Sanderbrand S, Weidemeyer C, et al. (2000) Plasmodium falciparum: Detection of the deoxyxylulose 5-phosphate reductoisomerase activity. Exp Parasitol 96: 182-186.
    • (2000) Exp Parasitol , vol.96 , pp. 182-186
    • Wiesner, J.1    Hintz, M.2    Altincicek, B.3    Sanderbrand, S.4    Weidemeyer, C.5
  • 67
    • 46449107969 scopus 로고    scopus 로고
    • A sporozoite asparagine-rich protein controls initiation of Plasmodium liver stage development
    • Silvie O, Goetz K, Matuschewski K, (2008) A sporozoite asparagine-rich protein controls initiation of Plasmodium liver stage development. PLoS Pathog 4: e1000086.
    • (2008) PLoS Pathog , vol.4
    • Silvie, O.1    Goetz, K.2    Matuschewski, K.3
  • 68
    • 28044470105 scopus 로고    scopus 로고
    • High efficiency transfection of Plasmodium berghei facilitates novel selection procedures
    • Janse CJ, Franke-Fayard B, Mair GR, Ramesar J, Thiel C, et al. (2006) High efficiency transfection of Plasmodium berghei facilitates novel selection procedures. Mol Biochem Parasitol 145: 60-70.
    • (2006) Mol Biochem Parasitol , vol.145 , pp. 60-70
    • Janse, C.J.1    Franke-Fayard, B.2    Mair, G.R.3    Ramesar, J.4    Thiel, C.5
  • 70
    • 0034795312 scopus 로고    scopus 로고
    • Detection of malaria liver-stages in mice infected through the bite of a single Anopheles mosquito using a highly sensitive real-time PCR
    • Bruna-Romero O, Hafalla JC, Gonzalez-Aseguinolaza G, Sano G, Tsuji M, et al. (2001) Detection of malaria liver-stages in mice infected through the bite of a single Anopheles mosquito using a highly sensitive real-time PCR. Int J Parasitol 31: 1499-1502.
    • (2001) Int J Parasitol , vol.31 , pp. 1499-1502
    • Bruna-Romero, O.1    Hafalla, J.C.2    Gonzalez-Aseguinolaza, G.3    Sano, G.4    Tsuji, M.5
  • 71
    • 75549090505 scopus 로고    scopus 로고
    • The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway/genome databases
    • Caspi R, Altman T, Dale JM, Dreher K, Fulcher CA, et al. (2010) The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway/genome databases. Nucleic Acids Res 38: D473-479.
    • (2010) Nucleic Acids Res , vol.38 , pp. 473-479
    • Caspi, R.1    Altman, T.2    Dale, J.M.3    Dreher, K.4    Fulcher, C.A.5
  • 72
    • 11244328060 scopus 로고    scopus 로고
    • The Pathway Tools software
    • Karp PD, Paley S, Romero P, (2002) The Pathway Tools software. Bioinformatics 18 (Suppl 1): S225-232.
    • (2002) Bioinformatics , vol.18 , Issue.SUPPL. 1 , pp. 225-232
    • Karp, P.D.1    Paley, S.2    Romero, P.3
  • 73
    • 33745659845 scopus 로고    scopus 로고
    • The 1.9 A resolution structure of Mycobacterium tuberculosis 1-deoxy-d-xylulose 5-phosphate reductoisomerase, a potential drug target
    • Henriksson LM, Bjorkelid C, Mowbray SL, Unge T, (2006) The 1.9 A resolution structure of Mycobacterium tuberculosis 1-deoxy-d-xylulose 5-phosphate reductoisomerase, a potential drug target. Acta Crystallogr D Biol Crystallogr D62: 807-813.
    • (2006) Acta Crystallogr D Biol Crystallogr , vol.D62 , pp. 807-813
    • Henriksson, L.M.1    Bjorkelid, C.2    Mowbray, S.L.3    Unge, T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.