Evaluation of the use of an autologous platelet-rich fibrin membrane to enhance tendon healing in dogs

American Journal of Veterinary Research

Volumn 72, Issue 5, 2011, Pages 699-705

  Visser, Lance C ^a,b   Arnoczky, Steven P ^a   Caballero, Oscar ^a   Gardner, Keri L ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; FAT; FIBRIN; PLATELET RICH FIBRIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOTRANSPLANTATION; BONE DEFECT; CELL REGENERATION; CONTROLLED STUDY; FRACTURE HEALING; HINDLIMB; MALE; NONHUMAN; PATELLA TENDON; QUANTITATIVE ANALYSIS; TENDON INJURY; THROMBOCYTE; TISSUE REPAIR; TREATMENT OUTCOME; VASCULAR TISSUE; VASCULARIZATION;

ANIMALS; BLOOD PLATELETS; DOGS; FIBRIN; HINDLIMB; MALE; MEMBRANES, ARTIFICIAL; PATELLAR LIGAMENT; VETERINARY MEDICINE; WOUND HEALING;

ANIMALIA; CANIS FAMILIARIS;

EID: 79955778167     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.72.5.699     Document Type: Article

References (50)

1. Sharma P, Maffulli N. Tendon injury and tendinopathy: healing and repair. J Bone Joint Surg Am 2005;87:187-202.
2. Goodship AE, Birch HL, Wilson AM. The pathobiology and repair of tendon and ligament injury. Vet Clin North Am Equine Pract 1994;10:323-349.
3. Hsu C, Chang J. Clinical implications of growth factors in flexor tendon wound healing. J Hand Surg Am 2004;29:551-563.
4. Molloy T, Wang Y, Murrell G. The roles of growth factors in tendon and ligament healing. Sports Med 2003;33:381-394.
5. Abrahamsson SO. Similar effects of recombinant human insulin-like growth factor-I and II on cellular activities in flexor ten-dons of young rabbits: experimental studies in vitro. J Orthop Res 1997;15:256-262.
6. Costa MA, Wu C, Pham BV, et al. Tissue engineering of flexor tendons: optimization of tenocyte proliferation using growth factor supplementation. Tissue Eng 2006;12:1937-1943.
7. Haupt JL, Donnelly BP, Nixon AJ. Effects of platelet-derived growth factor-BB on the metabolic function and morphologic features of equine tendon in explant culture. Am J Vet Res 2006;67:1595-1600.
8. Thomopoulos S, Harwood FL, Silva MJ, et al. Effect of several growth factors on canine flexor tendon fibroblast proliferation and collagen synthesis in vitro. J Hand Surg Am 2005;30:441-447.
9. Zachos TA, Bertone AL. Growth factors and their potential therapeutic applications for healing of musculoskeletal and other connective tissues. Am J Vet Res 2005;66:727-738.
10. Foster TE, Puskas BL, Mandelbaum BR, et al. Platelet-rich plasma: from basic science to clinical applications. Am J Sports Med 2009;37:2259-2272.
11. Bosch G, van Schie HT, de Groot MW, et al. Effects of platelet-rich plasma on the quality of repair of mechanically induced core lesions in equine superficial digital flexor tendons: a placebo-controlled experimental study. J Orthop Res 2010;28:211-217.
12. McCarrel T, Fortier L. Temporal growth factor release from platelet-rich plasma, trehalose lyophilized platelets, and bone marrow aspirate and their effect on tendon and ligament gene expression. J Orthop Res 2009;27:1033-1042.
13. Aspenberg P, Virchenko O. Platelet concentrate injection improves Achilles tendon repair in rats. Acta Orthop Scand 2004;75:93-99.
14. de Mos M, van der Windt AE, Jahr H, et al. Can platelet-rich plasma enhance tendon repair? A cell culture study. Am J Sports Med 2008;36:1171-1178.
15. Kajikawa Y, Morihara T, Sakamoto H, et al. Platelet-rich plasma enhances the initial mobilization of circulation-derived cells for tendon healing. J Cell Physiol 2008;215:837-845.
16. Mishra A, Pavelko T. Treatment of chronic elbow tendinosis with buffered platelet-rich plasma. Am J Sports Med 2006;34:1774-1778.
17. Sanchez M, Anitua E, Azofra J, et al. Comparison of surgically repaired Achilles tendon tears using platelet-rich fibrin matrices. Am J Sports Med 2007;35:245-251.
18. Schnabel LV, Mohammed HO, Miller BJ, et al. Platelet rich plasma (PRP) enhances anabolic gene expression patterns in flexor digitorum superficialis tendons. J Orthop Res 2007;25:230-240.
19. Waselau M, Sutter WW, Genovese RL, et al. Intralesional injection of platelet-rich plasma followed by controlled exercise for treatment of midbody suspensory ligament desmitis in Stan-dardbred racehorses. J Am Vet Med Assoc 2008;232:1515-1520.
20. Marx RE. Platelet-rich plasma (PRP): what is PRP and what is not PRP? Implant Dent 2001;10:225-228.
21. Ferguson MW, O'Kane S. Scar-free healing: from embryonic mechanisms to adult therapeutic intervention. Philos Trans R Soc Lond B Biol Sci 2004;359:839-850.
22. Gurtner GC, Werner S, Barrandon Y, et al. Wound repair and regeneration. Nature 2008;453:314-321.
23. Laurens N, Koolwijk P, de Maat MP. Fibrin structure and wound healing. J Thromb Haemost 2006;4:932-939.
24. Mosesson MW. Fibrinogen and fibrin structure and functions. J Thromb Haemost 2005;3:1894-1904.
25. Ahmed TA, Dare EV, Hincke M. Fibrin: a versatile scaffold for tissue engineering applications. Tissue Eng Part B Rev 2008;14:199-215.
26. Macri L, Silverstein D, Clark RA. Growth factor binding to the pericellular matrix and its importance in tissue engineering. Adv Drug Deliv Rev 2007;59:1366-1381.
27. O'Connell SM, Impeduglia T, Hessler K, et al. Autologous platelet-rich fibrin matrix as cell therapy in the healing of chronic lower-extremity ulcers. Wound Repair Regen 2008;16:749-756.
28. Visser LC, Arnoczky SP, Caballero O, et al. Platelet-rich fibrin constructs elute higher concentrations of transforming growth factor-β1 and increase tendon cell proliferation over time when compared to blood clots: a comparative in vitro analysis. Vet Surg 2010;39:811-817.
29. Kartus J, Movin T, Papadogiannakis N, et al. A radiographic and histologic evaluation of the patellar tendon after harvesting its central third. Am J Sports Med 2000;28:218-226.
30. Brunner G, Blakytny R. Extracellular regulation of TGF-beta activity in wound repair: growth factor latency as a sensor mechanism for injury. Thromb Haemost 2004;92:253-261.
31. Blakytny R, Ludlow A, Martin GE, et al. Latent TGF-beta1 activation by platelets. J Cell Physiol 2004;199:67-76.
32. Blobe GC, Schiemann WP, Lodish HF. Role of transforming growth factor beta in human disease. N Engl J Med 2000;342:1350-1358.
33. Klein MB, Yalamanchi N, Pham H, et al. Flexor tendon healing in vitro: effects of TGF-beta on tendon cell collagen production. J Hand Surg Am 2002;27:615-620.
34. Wynn TA. Cellular and molecular mechanisms of fibrosis. J Pathol 2008;214:199-210.
35. Akeda K, An HS, Okuma M, et al. Platelet-rich plasma stimulates porcine articular chondrocyte proliferation and matrix bio-synthesis. Osteoarthritis Cartilage 2006;14:1272-1280.
36. Sutter WW, Kaneps AJ, Bertone AL. Comparison of hematologic values and transforming growth factor-beta and insulin-like growth factor concentrations in platelet concentrates obtained by use of buffy coat and apheresis methods from equine blood. Am J Vet Res 2004;65:924-930.
37. Monteiro SO, Lepage OM, Theoret CL. Effects of platelet-rich plasma on the repair of wounds on the distal aspect of the fore-limb in horses. Am J Vet Res 2009;70:277-282.
38. Pietrzak WS, Eppley BL. Platelet rich plasma: biology and new technology. J Craniofac Surg 2005;16:1043-1054.
39. Roberts AB, Sporn MB. Transforming growth factor-beta. In: Clark RF, ed. The molecular and cellular biology of wound repair. 2nd ed. New York: Plenum Press, 1996;275-298.
40. Natsu-ume T, Nakamura N, Shino K, et al. Temporal and spatial expression of transforming growth factor-beta in the healing patellar ligament of the rat. J Orthop Res 1997;15:837-843.
41. Atkinson PJ, Oyen-Tiesma M, Zukosky DK, et al. Patellar tendon augmentation after removal of its central third limits joints tissue changes. J Orthop Res 1999;17:28-36.
42. Atkinson TS, Atkinson PJ, Mendenhall HV, et al. Patellar tendon and infrapatellar fat pad healing after harvest of an ACL graft. J Surg Res 1998;79:25-30.
43. Burks RT, Haut RC, Lancaster RL. Biomechanical and histological observations of the dog patellar tendon after removal of its central one-third. Am J Sports Med 1990;18:146-153.
44. Kamps BS, Linder LH, DeCamp CE, et al. The influence of immobilization versus exercise on scar formation in the rabbit patellar tendon after excision of the central third. Am J Sports Med 1994;22:803-811.
45. Milano G, Gigante A, Panni AS, et al. Patellar tendon healing after removal of its central third. A morphologic evaluation in rabbits. Knee Surg Sports Traumatol Arthrosc 2001;9:92-101.
46. Sanchis-Alfonso V, Subias-Lopez A, Monteagudo-Castro C, et al. Healing of the patellar tendon donor defect created after central-third patellar tendon autograft harvest. A long-term histological evaluation in the lamb model. Knee Surg Sports Traumatol Arthrosc 1999;7:340-348.
47. Kohn D, Deiler S, Rudert M. Arterial blood supply of the infrapatellar fat pad. Anatomy and clinical consequences. Arch Orthop Trauma Surg 1995;114:72-75.
48. Paulos LE, Butler DL, Noyes FR, et al. Intra-articular cruciate reconstruction. II: replacement with vascularized patellar tendon. Clin Orthop Relat Res 1983;78-84.
49. English A, Jones EA, Corscadden D, et al. A comparative assessment of cartilage and joint fat pad as a potential source of cells for autologous therapy development in knee osteoarthritis. Rheumatology (Oxford) 2007;46:1676-1683.
50. Wickham MQ, Erickson GR, Gimble JM, et al. Multipotent stromal cells derived from the infrapatellar fat pad of the knee. Clin Orthop Relat Res 2003;196-212.