Th2 immune responses and alternatively activated macrophages (AAMacs) in helminth infection in aged mice

Journal of Veterinary Medical Science

Volumn 73, Issue 4, 2011, Pages 511-516

  Sugawara, Yasuhiro ^a   Azuma, Noritsugu ^a   Onodera, Sachi ^a   Tsunoka, Yuichi ^a   Morimoto, Motoko ^a  

^a MIYAGI UNIVERSITY   (Japan)

Author keywords

Aging; Macrophages; Nematode; Small intestine; Th2 cytokine

Indexed keywords

CYTOKINE; MESSENGER RNA;

AGING; ANIMAL; C3H MOUSE; CLASSIFICATION; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; MACROPHAGE; MACROPHAGE ACTIVATION; METABOLISM; MOUSE; NEMATODE; NOTE; PATHOLOGY; PHYSIOLOGY; SMALL INTESTINE; STRONGYLE INFECTION; TH2 CELL;

AGING; ANIMALS; CYTOKINES; GENE EXPRESSION REGULATION; HELIGMOSOMATOIDEA; INTESTINE, SMALL; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; MICE, INBRED C3H; RNA, MESSENGER; STRONGYLIDA INFECTIONS; TH2 CELLS;

HELIGMOSOMOIDES POLYGYRUS; MUS; VERMES;

EID: 79955764274     PISSN: 09167250     EISSN: 13477439     Source Type: Journal    
DOI: 10.1292/jvms.10-0269     Document Type: Note

References (27)

1. al-Rayes, H., Pachas, W., Mirza, N., Ahern, D. J., Geha, R. S. and Vercelli, D. 1992. IgE regulation and lymphokine patterns in aging humans. J. Allergy Clin. Immunol. 90: 630-636.
2. Anthony, R. M., Urban, J. F. Jr., Alem, F., Hamed, H. A., Rozo, C. T., Boucher, J. L., Van Rooijen, N. and Gause, W. C. 2006. Memory T(H)2 cells induce alternatively activated macrophages to mediate protection against nematode parasites. Nat. Med. 12: 955-960.
3. Belosevic, M., Finbloom, D. S., Van Der Meide, P. H., Slayter, M. V. and Nacy, C. A. 1989. Administration of monoclonal anti-IFN-gamma antibodies in vivo abrogates natural resistance of C3H/HeN mice to infection with Leishmania major. J. Immunol. 143: 266-274.
4. Chiaramonte, M. G., Donaldson, D. D., Cheever, A. W. and Wynn, T. A. 1999. An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response. J. Clin. Invest. 104: 777-785.
5. Ernst, D. N., Hobbs, M. V., Torbett, B. E., Glasebrook, A. L., Rehse, M. A., Bottomly, K., Hayakawa, K., Hardy, R. R. and Weigle, W. O. 1990. Differences in the expression profiles of CD45RB, Pgp-1, and 3G11 membrane antigens and in the patterns of lymphokine secretion by splenic CD4+ T cells from young and aged mice. J. Immunol. 145: 1295-1302.
6. Ershler, W. B., Moore, A. L. and Socinski, M. A. 1984. Influenza and aging: age-related changes and the effects of thymosin on the antibody response to influenza vaccine. J. Clin. Immunol. 4: 445-454.
7. Finkelman, F. D., Shea-Donohue, T., Goldhill, J., Sullivan, C. A., Morris, S. C., Madden, K. B., Gause, W. C. and Urban, J. F. Jr. 1997. Cytokine regulation of host defense against parasitic gastrointestinal nematodes: lessons from studies with rodent models. Annu. Rev. Immunol. 15: 505-533.
8. Fujino, T., Yamada, M., Ichikawa, H., Fried, B., Arizono, N. and Tada, I. 1996. Rapid expulsion of the intestinal trematodes Echinostoma trivolvis and E. caproni from C3H/HeN mice after infection with Nippostrongylus brasiliensis. Parasitol. Res. 82: 577-579.
9. Gordon, S. 2003. Alternative activation of macrophages. Nat. Rev. 3: 23-35.
10. Gordon, S. and Taylor, P. R. 2005. Monocyte and macrophage heterogeneity. Nat. Rev. 5: 953-964.
11. + T cells impairs long term CD4+ T cell responses to influenza vaccine. J. Immunol. 173: 673-681.
12. Kishimoto, S., Tomino, S., Inomata, K., Kotegawa, S., Saito, T., Kuroki, M., Mitsuya, H. and Hisamitsu, S. 1978. Agerelated changes in the subsets and functions of human T lymphocytes. J. Immunol. 121: 1773-1780.
13. Kishimoto, S., Tomino, S., Mitsuya, H. and Nishimura, H. 1982. Age-related decrease in frequencies of B-cell precursors and specific helper T cells involved in the IgG anti-tetanus toxoid antibody production in humans. Clin. Immunol. Immunopathol. 25: 1-10.
14. Kuroda, E., Kito, T. and Yamashita, U. 2002. Reduced expression of STAT4 and IFN-gamma in macrophages from BALB/c mice. J. Immunol. 168: 5477-5482.
15. Liu, Q., Sundar, K., Mishra, P. K., Mousavi, G., Liu, Z., Gaydo, A., Alem, F., Lagunoff, D., Bleich, D. and Gause, W. C. 2009. Helminth infection can reduce insulitis and type 1 diabetes through CD25- and IL-10-independent mechanisms. Infect. Immun. 77: 5347-5358.
16. Morimoto, M., Morimoto, M., Whitmire, J., Xiao, S., Anthony, R. M., Mirakami, H., Star, R. A., Urban, J. F. Jr. and Gause, W. C. 2004. Peripheral CD4 T cells rapidly accumulate at the host: parasite interface during an inflammatory Th2 memory response. J. Immunol. 172: 2424-2430.
17. Morimoto, M., Morimoto, M., Zhao, A., Madden, K. B., Dawson, H., Finkelman, F. D., Mentink-Kane, M., Urban, J. F. Jr., Wynn, T. A. and Shea-Donohue, T. 2006. Functional importance of regional differences in localized gene expression of receptors for IL-13 in murine gut. J. Immunol. 176: 491-495.
18. Munder, M., Eichmann, K., Moran, J. M., Centeno, F., Soler, G. and Modolell, M. 1999. Th1/Th2-regulated expression of arginase isoforms in murine macrophages and dendritic cells. J. Immunol. 163: 3771-3777.
19. Raes, G., Noel, W., Beschin, A., Brys, L., de Baetselier, P. and Hassanzadeh, G. H. 2002. FIZZ1 and Ym as tools to discriminate between differentially activated macrophages. Dev. Immunol. 9: 151-159.
20. Smith, P., Mangan, N. E., Walsh, C. M., Fallon, R. E., McKenzie, A. N., van Rooijen, N. and Fallon, P. G. 2007. Infection with a helminth parasite prevents experimental colitis via a macrophage-mediated mechanism. J. Immunol. 178: 4557-4566.
21. Svetic, A., Madden, K. B., Zhou, X. D., Lu, P., Katona, I. M., Finkelman, F. D., Urban, J. F. Jr. and Gause, W. C. 1993. A primary intestinal helminthic infection rapidly induces a gutassociated elevation of Th2-associated cytokines and IL-3. J. Immunol. 150: 3434-3441.
22. Utsuyama, M., Hirokawa, K., Kurashima, C., Fukayama, M., Inamatsu, T., Suzuki, K., Hashimoto, W. and Sato, K. 1992. Differential age-change in the numbers of CD4+CD45RA+ and CD4+CD29+ T cell subsets in human peripheral blood. Mech. Ageing Dev. 63: 57-68.
23. Walters, C. S. and Claman, H. N. 1975. Age-related changes in cell-mediated immunity in BALB/C mice. J. Immunol. 115: 1438-1443.
24. Wynn, T. A. 2004. Fibrotic disease and the T(H)1/T(H)2 paradigm. Nat. Rev. 4: 583-594.
25. Wynn, T. A., Thompson, R. W., Cheever, A. W. and Mentink- Kane, M. M. 2004. Immunopathogenesis of schistosomiasis. Immunol. Rev. 201: 156-167.
26. Yen, C. J., Lin, S. L., Huang, K. T. and Lin, R. H. 2000. Ageassociated changes in interferon-gamma and interleukin-4 secretion by purified human CD4+ and CD8+ T cells. J. Biomed. Sci. 7: 317-321.
27. Zhao, A., Urban, J. F. Jr., Anthony, R. M., Sun, R., Stiltz, J., van Rooijen, N., Wynn, T. A., Gause, W. C. and Shea-Donohue, T. 2008. Th2 cytokine-induced alterations in intestinal smooth muscle function depend on alternatively activated macrophages. Gastroenterology 135: 217-225.