Could an allosteric gating model explain the role of TRPA1 in cold hypersensitivity?

Journal of Neuroscience

Volumn 31, Issue 15, 2011, Pages 5554-5556

  Salazar, Marcelo ^a,b   Moldenhauer, Hans ^a   Baez Nieto, David ^a  

^a UNIVERSIDAD DE VALPARAÍSO   (Chile)

^b UNIVERSIDAD AUSTRAL DE CHILE   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

ALLYL ISOTHIOCYANATE; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1;

ARTICLE; CHANNEL GATING; COLD SENSITIVITY; EQUILIBRIUM CONSTANT; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; SPINAL GANGLION; THERMOREGULATION;

EID: 79955760873     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.6775-10.2011     Document Type: Article

References (9)

1. Brauchi S, Orio P, Latorre R (2004) Clues to understanding cold sensation: hermodynamics and electrophysiological analysis of the coldreceptor TRPM8. Proc Natl Acad Sci USA 101:15494-15499.
2. del Camino D, Murphy S, Heiry M, Barrett LB, Earley TJ, Cook CA, Petrus MJ, Zhao M, D'Amours M, Deering N, Brenner GJ, Costi-gan M, Hayward NJ, Chong JA, Fanger CM, Woolf CJ, Patapoutian A, Moran MM (2010) TRPA1 contributes to cold hypersensitivity. J Neurosci 30:15165-15174.
3. Horrigan FT, Aldrich RW (1999) Allosteric voltage gating of potassium channels II. Mslo channel gating charge movement in the absence of Ca(2 +). J Gen Physiol 114:305-336.
4. Karashima Y, Talavera K, Everaerts W, Janssens A, Kwan KY, Vennekens R, Nilius B, Voets T (2009) TRPA1 acts as a cold sensor in vitro and in vivo. Proc Natl Acad Sci USA 106:1273-1278.
5. Klionsky L, Tamir R, Gao B, Wang W, Immke DC, Nishimura N, Gavva NR (2007) Species-specific pharmacology of trichloro(sulfanyl) ethyl benzamides as transient receptor potential ankyrin 1 (TRPA1) antagonists. Mol Pain 3:39.
6. Latorre R, Brauchi S, Orta G, Zaelzer C, Vargas G (2007) ThermoTRP channels as modular proteins with allosteric gating. Cell Calcium 42:427-438.
7. Latorre R, Zaelzer C, Brauchi S (2009) Structure-functional intimacies of transient receptor potential channels. Q Rev Biophys 42:201-246.
8. Matta JA, Ahern GP (2007) Voltage is a partial activator of rat thermosensitive TRP channels. J Physiol 585:469 - 482.
9. Sawada Y, Hosokawa H, Hori A, Matsumura K, Kobayashi S (2007) Cold sensitivity of recombinant TRPA1 channels. Brain Res 1160: 39-46.