Improved cardiac metabolism and activation of the RISK pathway contributes to improved post-ischemic recovery in calorie restricted mice

Journal of Molecular Medicine

Volumn 89, Issue 3, 2011, Pages 291-302

  Miranda M Y Sung, ^a   Carrie Lynn M Soltys, ^a   Grant Masson, ^a   Jamie J Boisvenue, ^a   Dyck, Jason R B ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Energy metabolism; Heart; Ischemia; Signal transduction

Indexed keywords

ADENOSINE TRIPHOSPHATE; FATTY ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHOTRANSFERASE; PROTEIN KINASE B; REPERFUSION INJURY SALVAGE KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALORIC RESTRICTION; ENERGY METABOLISM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FATTY ACID OXIDATION; GLUCOSE OXIDATION; GLYCOLYSIS; HEART MUSCLE ISCHEMIA; HEART MUSCLE METABOLISM; HEART PROTECTION; MOUSE; NONHUMAN; REPERFUSION INJURY; SIGNAL TRANSDUCTION;

ADENOSINE TRIPHOSPHATE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BLOTTING, WESTERN; CALORIC RESTRICTION; FATTY ACIDS; GLYCOLYSIS; MICE; MICE, INBRED C57BL; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; PROTEIN KINASES; SIGNAL TRANSDUCTION;

EID: 79955748414     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-010-0703-5     Document Type: Article

References (36)

1. Bolli R, Marban E (1999) Molecular and cellular mechanisms of myocardial stunning. Physiol Rev 79:609-634 (Pubitemid 29210931)
2. Moens AL, Claeys MJ, Timmermans JP, Vrints CJ (2005) Myocardial ischemia/reperfusion injury, a clinical view on a complex pathophysiological process. Int J Cardiol 100:179-190
3. Yellon DM, Downey JM (2003) Preconditioning the myocardium: From cellular physiology to clinical cardiology. Physiol Rev 83:1113-1151 (Pubitemid 37222269)
4. Peart JN, Headrick JP (2008) Sustained cardioprotection: Exploring unconventional modalities. Vascul Pharmacol 49:63-70
5. Shinmura K, Tamaki K, Bolli R (2005) Short-term caloric restriction improves ischemic tolerance independent of opening of ATP-sensitive K+ channels in both young and aged hearts. J Mol Cell Cardiol 39:285-296 (Pubitemid 40995018)
6. Shinmura K, Tamaki K, Saito K, Nakano Y, Tobe T, Bolli R (2007) Cardioprotective effects of short-term caloric restriction are mediated by adiponectin via activation of AMP-activated protein kinase. Circulation 116:2809-2817 (Pubitemid 350291223)
7. Bertomeu-Gonzalez V, Bouzas-Mosquera A, Kaski JC (2006) Role of trimetazidine in management of ischemic cardiomyopathy. Am J Cardiol 98:19J-24J
8. Liu Q, Docherty JC, Rendell JC, Clanachan AS, Lopaschuk GD (2002) High levels of fatty acids delay the recovery of intracellular pH and cardiac efficiency in post-ischemic hearts by inhibiting glucose oxidation. J Am Coll Cardiol 39:718-725 (Pubitemid 34158171)
9. Lopaschuk GD, Collins-Nakai R, Olley PM, Montague TJ, McNeil G, Gayle M, Penkoske P, Finegan BA (1994) Plasma fatty acid levels in infants and adults after myocardial ischemia. Am Heart J 128:61-67 (Pubitemid 24227136)
10. Dyck JR, Lopaschuk GD (2006) AMPK alterations in cardiac physiology and pathology: Enemy or ally? J Physiol 574:95-112 (Pubitemid 43905800)
11. Liu B, Clanachan AS, Schulz R, Lopaschuk GD (1996) Cardiac efficiency is improved after ischemia by altering both the source and fate of protons. Circ Res 79:940-948 (Pubitemid 26359235)
12. Liu B, el Alaoui-Talibi Z, Clanachan AS, Schulz R, Lopaschuk GD (1996) Uncoupling of contractile function from mitochondrial TCA cycle activity and MVO2 during reperfusion of ischemic hearts. Am J Physiol 270:H72-H80
13. Kantor PF, Dyck JR, Lopaschuk GD (1999) Fatty acid oxidation in the reperfused ischemic heart. Am J Med Sci 318:3-14 (Pubitemid 30387269)
14. Stanley WC, Lopaschuk GD, Hall JL, McCormack JG (1997) Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions. Potential for pharmacological interventions. Cardiovasc Res 33:243-257
15. Hausenloy DJ, Tsang A, Mocanu MM, Yellon DM (2005) Ischemic preconditioning protects by activating prosurvival kinases at reperfusion. Am J Physiol Heart Circ Physiol 288: H971-H976 (Pubitemid 40139686)
16. Kuang M, Febbraio M, Wagg C, Lopaschuk GD, Dyck JR (2004) Fatty acid translocase/CD36 deficiency does not energetically or functionally compromise hearts before or after ischemia. Circulation 109:1550-1557 (Pubitemid 38420185)
17. Finegan BA, Gandhi M, Cohen MR, Legatt D, Clanachan AS (2003) Isoflurane alters energy substrate metabolism to preserve mechanical function in isolated rat hearts following prolonged noflow hypothermic storage. Anesthesiology 98:379-386 (Pubitemid 36592806)
18. An D, Pulinilkunnil T, Qi D, Ghosh S, Abrahani A, Rodrigues B (2005) The metabolic "switch" AMPK regulates cardiac heparinreleasable lipoprotein lipase. Am J Physiol Endocrinol Metab 288: E246-E253 (Pubitemid 40023814)
19. Cross HR, Opie LH, Radda GK, Clarke K (1996) Is a high glycogen content beneficial or detrimental to the ischemic rat heart? A controversy resolved. Circ Res 78:482-491
20. Kramer HF, Witczak CA, Taylor EB, Fujii N, Hirshman MF, Goodyear LJ (2006) AS160 regulates insulin-and contractionstimulated glucose uptake in mouse skeletal muscle. J Biol Chem 281:31478-31485 (Pubitemid 46041412)
21. McCurdy CE, Davidson RT, Cartee GD (2003) Brief calorie restriction increases Akt2 phosphorylation in insulin-stimulated rat skeletal muscle. Am J Physiol Endocrinol Metab 285:E693-E700 (Pubitemid 37176419)
22. Giani JF, Bonkowski MS, Munoz MC, Masternak MM, Turyn D, Bartke A, Dominici FP (2008) Insulin signaling cascade in the hearts of long-lived growth hormone receptor knockout mice: Effects of calorie restriction. J Gerontol A Biol Sci Med Sci 63:788-797
23. Nishino Y, Webb IG, Davidson SM, Ahmed AI, Clark JE, Jacquet S, Shah AM, Miura T, Yellon DM, Avkiran M, Marber MS (2008) Glycogen synthase kinase-3 inactivation is not required for ischemic preconditioning or postconditioning in the mouse. Circ Res 103:307-314
24. Sinclair DA (2005) Toward a unified theory of caloric restriction and longevity regulation. Mech Ageing Dev 126:987-1002 (Pubitemid 41033180)
25. Kondo M, Shibata R, Miura R, Shimano M, Kondo K, Li P, Ohashi T, Kihara S, Maeda N, Walsh K, Ouchi N, Murohara T (2009) Caloric restriction stimulates revascularization in response to ischemia via adiponectin-mediated activation of endothelial nitric-oxide synthase. J Biol Chem 284:1718-1724
26. Shibata R, Sato K, Pimentel DR, Takemura Y, Kihara S, Ohashi K, Funahashi T, Ouchi N, Walsh K (2005) Adiponectin protects against myocardial ischemia-reperfusion injury through AMPKand COX-2-dependent mechanisms. Nat Med 11:1096-1103 (Pubitemid 41486832)
27. Shibata R, Ouchi N, Ito M, Kihara S, Shiojima I, Pimentel DR, Kumada M, Sato K, Schiekofer S, Ohashi K, Funahashi T, Colucci WS, Walsh K (2004) Adiponectin-mediated modulation of hypertrophic signals in the heart. Nat Med 10:1384-1389 (Pubitemid 40022722)
28. Hardie DG (2007) AMP-activated protein kinase as a drug target. Annu Rev Pharmacol Toxicol 47:185-210
29. Lopaschuk GD, Barr R, Thomas PD, Dyck JR (2003) Beneficial effects of trimetazidine in ex vivo working ischemic hearts are due to a stimulation of glucose oxidation secondary to inhibition of long-chain 3-ketoacyl coenzyme a thiolase. Circ Res 93:e33-e37
30. Dean DJ, Brozinick JT Jr, Cushman SW, Cartee GD (1998) Calorie restriction increases cell surface GLUT-4 in insulinstimulated skeletal muscle. Am J Physiol 275:E957-E964
31. Doenst T, Richwine RT, Bray MS, Goodwin GW, Frazier OH, Taegtmeyer H (1999) Insulin improves functional and metabolic recovery of reperfused working rat heart. Ann Thorac Surg 67:1682-1688 (Pubitemid 29301311)
32. Dean DJ, Cartee GD (2000) Calorie restriction increases insulinstimulated tyrosine phosphorylation of insulin receptor and insulin receptor substrate-1 in rat skeletal muscle. Acta Physiol Scand 169:133-139
33. McCurdy CE, Cartee GD (2005) Akt2 is essential for the full effect of calorie restriction on insulin-stimulated glucose uptake in skeletal muscle. Diabetes 54:1349-1356 (Pubitemid 40586663)
34. Hausenloy DJ, Yellon DM (2004) New directions for protecting the heart against ischaemia-reperfusion injury: Targeting the reperfusion injury salvage kinase (RISK) pathway. Cardiovasc Res 61:448-460 (Pubitemid 38210151)
35. Crackower MA, Oudit GY, Kozieradzki I, Sarao R, Sun H, Sasaki T, Hirsch E, Suzuki A, Shioi T, Irie-Sasaki J, Sah R, Cheng HY, Rybin VO, Lembo G, Fratta L, Oliveira-dos-Santos AJ, Benovic JL, Kahn CR, Izumo S, Steinberg SF, Wymann MP, Backx PH, Penninger JM (2002) Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell 110:737-749 (Pubitemid 35283963)
36. Sasaki T, Irie-Sasaki J, Jones RG, Oliveira-dos-Santos AJ, Stanford WL, Bolon B, Wakeham A, Itie A, Bouchard D, Kozieradzki I, Joza N, Mak TW, Ohashi PS, Suzuki A, Penninger JM (2000) Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration. Science 287:1040-1046