Dilated intercellular spaces and chronic cough as an extra-oesophageal manifestation of gastrooesophageal reflux disease

Pulmonary Pharmacology and Therapeutics

Volumn 24, Issue 3, 2011, Pages 272-275

  Orlando, Roy C ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Paracellular permeability; Sensitization; Substance P; TRPV 1; Vagus nerve

Indexed keywords

SUBSTANCE P;

ARTICLE; CELL MEMBRANE PERMEABILITY; CHRONIC DISEASE; CORRELATION ANALYSIS; COUGHING; ESOPHAGUS MUCOSA; GASTROESOPHAGEAL REFLUX; HEARTBURN; HISTOPATHOLOGY; HUMAN; INTERCELLULAR SPACE; NOCICEPTIVE RECEPTOR; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; BRONCHI; CHRONIC DISEASE; COUGH; EXTRACELLULAR SPACE; GASTRIC ACID; GASTROESOPHAGEAL REFLUX; HEARTBURN; HUMANS; MUCOUS MEMBRANE; PERMEABILITY; SOLITARY NUCLEUS; TRACHEA;

EID: 79955718965     PISSN: 10945539     EISSN: 15229629     Source Type: Journal    
DOI: 10.1016/j.pupt.2010.10.007     Document Type: Article

References (28)

1. Orlando R.C. Reflux esophagitis. Textbook of Gastroenterology 1999, 1235-1263. JB Lippincott Williams & Wilkins, Philadelphia. T. Yamada, D.H. Alpers, L. Laine, C. Owyang, D.W. Powell (Eds.).
2. Kollarik M., Brozmanova M. Cough and gastroesophageal reflux: insights from animal models. Pulm Pharmacol Ther 2008.
3. Tobey N.A., Carson J.L., Alkiek R.A., Orlando R.C. Dilated intercellular spaces: a morphological feature of acid reflux - damaged human esophageal epithelium. Gastroenterology 1996, 111:1200-1205.
4. Solcia E., Villani L., Luinetti O., Trespi E., Strada E., Tinelli C., et al. Altered intercellular glycoconjugates and dilated intercellular spaces of esophageal epithelium in reflux disease. Virchows Arch 2000, 436:207-216.
5. Farre R., De Vos R., Geboes K., Verbecke K., Vanden Berghe P., Depoortere I., et al. Critical role of stress in increased oesophageal mucosa permeability and dilated intercellular spaces. Gut 2007, 56:1191-1197.
6. Caviglia R., Ribolsi M., Maggiano N., Gabbrielli A.M., Emerenziani S., Guarino M.P., et al. Dilated intercellular spaces of esophageal epithelium in nonerosive reflux disease patients with physiological esophageal acid exposure. Am J Gastroenterol 2005, 100:543-548.
7. Ravelli A.M., Villanacci V., Ruzzenenti N., Grigolato P., Tobanelli P., Klersy C., et al. Dilated intercellular spaces: a major morphological feature of esophagitis. J Pediatr Gastroenterol Nutr 2006, 42:510-515.
8. Ismail-Beigi F.H.P., Pope C.E. Histological consequences of gastroesophageal refluxes in man. Gastroenterology 1970, 58:163-174.
9. Orlando L.A., Orlando R.C. Dilated intercellular spaces as a marker of GERD. Curr Gastroenterol Rep 2009, 11:190-194.
10. Bove M., Vieth M., Dombrowski F., Ny L., Ruth M., Lundell L. Acid challenge to the human esophageal mucosa: effects on epithelial architecture in health and disease. Dig Dis Sci 2005, 50:1488-1496.
11. Calabrese C., Bortolotti M., Fabbri A., Areni A., Cenacchi G., Scialpi C., et al. Reversibility of GERD ultrastructural alterations and relief of symptoms after omeprazole treatment. Am J Gastroenterol 2005, 100:537-542.
12. Kahrilas P.J. Dilated intercellular spaces: extending the reach of the endoscope. Am J Gastroenterol 2005, 100:549-550.
13. Xue Y.Z.L., Lin S. The changes of esophageal epithelium intercellular spaces before and after omeprazole treatment in GERD patients. Gastroenterology 2007, 132:A281.
14. Tobey N.A., Hosseini S.S., Argote C.M., Dobrucali A.M., Awayda M.S., Orlando R.C. Dilated intercellular spaces and shunt permeability in nonerosive acid-damaged esophageal epithelium. Am J Gastroenterol 2004, 99:13-22.
15. Tobey N.A., Gambling T.M., Vanegas X.C., Carson J.L., Orlando R.C. Physicochemical basis for dilated intercellular spaces in non-erosive acid-damaged rabbit esophageal epithelium. Dis Esophagus 2008, 21:757-764.
16. Bielefeldt K., Davis B.M. Differential effects of ASIC3 and TRPV1 deletion on gastroesophageal sensation in mice. Am J Physiol Gastrointest Liver Physiol 2008, 294:G130-G138.
17. Mathews P.J.A.Q., Facer P., Davis J.B., Thompson D.G., Anand P. Increased capsaicin receptor TRPV1 nerve fibers in the inflammed human esophagus. Eur J Gastroenterol Hepatol 2004, 16:897-902.
18. Barlow W.J., Orlando R.C. The pathogenesis of heartburn in nonerosive reflux disease: a unifying hypothesis. Gastroenterology 2005, 128:771-778.
19. Kern M., Hofmann C., Hyde J., Shaker R. Characterization of the cerebral cortical representation of heartburn in GERD patients. Am J Physiol Gastrointest Liver Physiol 2004, 286:G174-G181.
20. Chen C.Y., Joad J.P., Bric J., Bonham A.C. Central mechanisms I: plasticity of central pathways. Handb Exp Pharmacol 2009, 187-201.
21. Bonham A.C., Sekizawa S., Chen C.Y., Joad J.P. Plasticity of brainstem mechanisms of cough. Respir Physiol Neurobiol 2006, 152:312-319.
22. Hamamoto J., Kohrogi H., Kawano O., Iwagoe H., Fujii K., Hirata N., et al. Esophageal stimulation by hydrochloric acid causes neurogenic inflammation in the airways in guinea pigs. J Appl Physiol 1997, 82:738-745.
23. Kohrogi H., Hamamoto J., Kawano O., Iwagoe H., Fujii K., Hirata N., et al. The role of substance P release in the lung with esophageal acid. Am J Med 2001, 111(Suppl. 8A):25S-30S.
24. Lang I.M., Haworth S.T., Medda B.K., Roerig D.L., Forster H.V., Shaker R. Airway responses to esophageal acidification. Am J Physiol Regul Integr Comp Physiol 2008, 294:R211-R219.
25. Smith JA, Decalmer S, Kelsall A, McGuinness K, Jones H, Galloway S, et al, Acoustic cough-reflux associations in chronic cough: potential triggers and mechanisms. Gastroenterology;139:754-762.
26. Javorkova N., Varechova S., Pecova R., Tatar M., Balaz D., Demeter M., et al. Acidification of the oesophagus acutely increases the cough sensitivity in patients with gastro-oesophageal reflux and chronic cough. Neurogastroenterol Motil 2008, 20:119-124.
27. Haque R.A., Usmani O.S., Barnes P.J. Chronic idiopathic cough: a discrete clinical entity?. Chest 2005, 127:1710-1713.
28. Chang A.B., Lasserson T.J., Kiljander T.O., Connor F.L., Gaffney J.T., Garske L.A. Systematic review and meta-analysis of randomised controlled trials of gastro-oesophageal reflux interventions for chronic cough associated with gastro-oesophageal reflux. BMJ 2006, 332:11-17.