Synthesis of naratriptan using new intermediate N-benzyl-N-methyl ethenesulfonamide

Der Pharma Chemica

Volumn 3, Issue 2, 2011, Pages 167-171

  Venugopala Rao, B ^a   Krishnana, V S H ^a   Venkateswara Rao, K ^a   Ravi Sankar, V ^a   Dubey, P K ^b  

^a Dissymmetrix Pvt Ltd   (India)

^b JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY   (India)

Author keywords

Debenzylation; Heack reaction; Indole derivatives; N benzyl N methylethenesulfonamide; Nartriptan

Indexed keywords

5 BROMO 3 (1 METHYL 1,2,3,6 TETRAHYDRO PYRIDIN 4 YL) 1H INDOLE; INDOLE DERIVATIVE; N BENZYL N METHYL 2 [3 (1 METHYL 1,2,3,6 TETRAHYDRO PYRIDINE 4 YL) 1H INDOL 5 YL]ETHENE SULFONAMIDE; N BENZYL N METHYL 2 [3 (1 METHYLPIPERDIN 4 YL) 1H INDOL 5 YL]ETHANESULFONAMIDE; N BENZYL N METHYLETHENESULFONAMIDE; NARATRIPTAN; UNCLASSIFIED DRUG;

ARTICLE; DEBENZYLATION; DRUG PURIFICATION; DRUG PURITY; DRUG STRUCTURE; DRUG SYNTHESIS; HECK REACTION; HYDROGENATION;

EID: 79955711366     PISSN: None     EISSN: 0975413X     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. P.PA. Humphrey, W. Feniuk, M.J Perren, H.E.Connor, A.W.Oxford, I.H.Coates, and D. Butina. Br. J.Pharmacol, 1988, 94, 1123.
2. W. Feniuk, and P.P.A. Humphrey. Drug Development Research, 1992, 26, 235.
3. S.J.Hopkins, Drugs of Today, 1992, 28, 155.
4. R.C.Glen, G.R. Martin, A.P. Hill, R.M. Hyde, P.M.Woollard, J.A. Salmon, J. Buckingham, and A.D. Robertson, J. Med. Chem., 1995, 38, 3566.
5. H.Connor, C.T.O. Shaughnessy, W. Feniuk, M.J. Perren, P.C. North, A.W. Oxford, D. Butina, M. Owen, and P.P.A.Humphrey. Br.J.Pharmacol,1993, 108, 99.
6. L.J.Street, R.Baker, W.B. Davey, A.R. Gublin, R.A. Jelley, A.J. Reeve, H. Routledge, F. Sternfeld, A.P. Watt, M.S.Beer, D.N. Middlemis, A.J.Noble, J.A. Stanton, K. Scholey, R.J. Hargreaves, B. Sohal, M.I.Graham, and V.G.Matassa, J. Med. Chem. 1995, 38, 1799.
7. Drugs of the Future, 1997, 22, (3), 221-224
8. J. Bosch,T.Roca, M. Aemengol, and D. fernensz-forner, Tetrahedron, 2001, 57, 1041-1048.
9. Oxford, Alexander willam. GB Patent, 2208646.
10. C. Giuliana tesoro, Dobbsferry, US Patent. 3761473.
11. Béla Pete, Gyula Simig, László Poszávácz, and László Toke. Heterocycles, 2003, 60, (11), 2441-2455.
12. J. Bosch, T. Roca, M. Aemengol and D. fernensz-forner., Tetrahedron., 2001, 57,1041-11048.
13. László Poszávácz, Gyula Simig, József Fetter, and Ferenc Bertha. Heterocycles, 2006, 68, (4) 713-719.