Generation of anti-trypanosomal agents through concise synthesis and structural diversification of sesquiterpene analogues

Journal of the American Chemical Society

Volumn 133, Issue 18, 2011, Pages 7096-7105

  Oguri, Hiroki ^a   Hiruma, Takahisa ^a   Yamagishi, Yutaka ^a   Oikawa, Hideaki ^a   Ishiyama, Aki ^b   Otoguro, Kazuhiko ^b   Yamada, Haruki ^b   Omuraz, Satoshi ^b  

^a HOKKAIDO UNIVERSITY   (Japan)

^b KITASATO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMISININ; BIOLOGICAL ACTIVITIES; CONCISE SYNTHESIS; CYCLIZATIONS; HIGH QUALITY; IN-VITRO; NATURAL PRODUCTS; NEGLECTED DISEASE; PHARMACOPHORES; PRIMARY SCREENING; RING-CLOSING METATHESIS REACTIONS; SESQUITERPENES; SMALL-MOLECULE LIBRARY; STRUCTURAL FEATURE; STRUCTURAL VARIATIONS; SURAMIN; SYNTHETIC PROCESS; THREE-DIMENSIONAL SHAPE;

OLEFINS; SCAFFOLDS; STEREOCHEMISTRY; THREE DIMENSIONAL;

CYCLIZATION;

ALKADIENE; ANTHECULARIN DERIVATIVE; ANTITRYPANOSOMAL AGENT; ARTEMISININ; ARTEMISININ DERIVATIVE; EFLORNITHINE; NATURAL PRODUCT; PEROXIDE; SESQUITERPENE DERIVATIVE; SURAMIN; TRANSTAGANOLIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; CYCLIZATION; CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; IC 50; MAMMAL CELL; NONHUMAN; RING CLOSING METATHESIS; STEREOCHEMISTRY; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA BRUCEI;

ARTEMISININS; CELL LINE; HUMANS; MOLECULAR STRUCTURE; SESQUITERPENES; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI;

EID: 79955688676     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja200374q     Document Type: Article

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