Dragon's Blood extract has antithrombotic properties, affecting platelet aggregation functions and anticoagulation activities

Journal of Ethnopharmacology

Volumn 135, Issue 2, 2011, Pages 510-514

  Xin, Nian ^a   Li, Yu Juan ^a   Li, Yan ^a   Dai, Rong Ji ^a   Meng, Wei Wei ^a   Chen, Yan ^b   Schlappi, Michael ^c   Deng, Yu Lin ^a  

^a BEIJING INSTITUTE OF TECHNOLOGY   (China)

^b Beijing BIT and GY Pharmaceutical R and D Co Ltd   (China)

^c MARQUETTE UNIVERSITY   (United States)

Author keywords

Anticoagulation activity; Antithrombotic effect; Blood stasis model; Dragon's Blood extract; Platelet functions

Indexed keywords

CHINESE DRUG; DRAGON BLOOD EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICOAGULATION; ARTICLE; CONTROLLED STUDY; DRACAENA; DRACAENA COCHINCHINENSIS; DRUG EFFECT; DRUG ISOLATION; DRUG SYNTHESIS; HEMOSTASIS; MOUSE; NONHUMAN; RAT; THROMBOCYTE AGGREGATION; THROMBOSIS;

ANIMALS; ANTICOAGULANTS; ANTITHROMBINS; MICE; PLANT EXTRACTS; PLATELET AGGREGATION INHIBITORS; RATS; RATS, WISTAR;

DRACAENA COCHINCHINENSIS;

EID: 79955678071     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2011.03.063     Document Type: Article

References (30)

1. V. Ballabeni, F. Calcina, M. Tognolini, O. Bruno, C. Manotti, and E. Barocelli Effects of subacute treatment with benzopyranopyrimidines in hemostasis and experimental thrombosis in mice Life Science 74 2004 1851 1859 (Pubitemid 38167554)
2. Q.Q. Bao, L. Zhang, X.Q. Li, Z.L. Li, and Y.M. Liu Clinical significance of acute infection in elderly patients with thrombotic disease Chinese Journal of Gerontology 17 2009 2253 2255
3. L. Brass Fifty (or more) ways to leave your platelets (in a thrombus) Arteriosclerosis, Thrombosis, and Vascular Biology 24 2004 989 991 (Pubitemid 38737820)
4. Q.B. Chen, Z.S. Shen, Z.B. Wei, and Z.X. Zhong Study on the pharmacological function of stimulate circulation to end stasis of flavone from Momordica grosvenori Guangxi Sciences 4 2005 316 319
5. C.S. Choy, C.M. Hu, W.T. Chiu, C.S. Kei Lam, Y. Ting, S.H. Tsai, and T.C. Wang Suppression of lipopolysaccharide-induced of inducible nitric oxide synthase and cyclooxygenase-2 by Sanguis draconis, a Dragon's Blood resin, in RAW 264.7 cells Journal of Ethnopharmacology 115 2008 455 462 (Pubitemid 350299084)
6. W.O Foye, X. Wang, and H. Wang Synthesis and platelet aggregation inhibitory effects of Harman and phthalide derivatives related to Ligusticum chuanxiong Hort constituents Medicinal Chemistry Research 7 1997 180 191 (Pubitemid 127500599)
7. P. Gresele, C. Corona, P. Alberti, and G.G. Nenci Picetamide protects mice from death in a pulmonary embalism model by a mechanism independent from thromboxane suppression Thrombosis and Haemostasis 64 1990 80 86 (Pubitemid 20301854)
8. L.A. Gurgel, J.J. Sidrim, D.T. Martins, V. Cechinel Filho, and V.S. Rao In vitro antifungal activity of dragon's blood from Croton urucurana against dermatophytes Journal of Ethnopharmacology 97 2001 409 412
9. M. Jia Effects of flavone in Resina draconis on platelet aggegation in rabbits and rats and experimental venous thrombosis in rats Pharmacology and Clinics of Chinese Materia Medica 16 2000 18 19
10. X.L. Jin, B.L. Chen, W.J. Wu, Z. Gu, M.H. Jiang, Z.B. Zhang, and J.C. Dong Effects of eight danshensu's derivatives on rabbit platelet aggregation Journal of Shanghai Medica (University) 27 2000 181 184
11. K. Jones Review of sangre de drago (Croton lechleri) - a South American tree sap in the treatment of diarrhea, inflammation, insect bites, viral infections, and wounds: traditional uses to clinical research Journal Alternative and Complementary Medicine 9 2003 877 896 (Pubitemid 38049705)
12. Y. Kong, W.J. Pan, Y.J. Huang, J.Y. Yang, Y.H. Chen, Y.X. Yan, X.J. Zhang, and C.F. Wu Effects of Fufang sanqi pills on hemorheological parameters, platelet aggregation and thrombus formation in experimental animals Modern Chinese Medicine 8 2006 8 10
13. A.P. Lu, H.W. Jia, C. Xiao, and Q.P. Lu Theory of traditional Chinese medicine and therapeutic method of diseases World Journal of Gastroenterology 10 2004 1854 1856 (Pubitemid 39029278)
14. T.L. Lu, Y.L. Wu, L.Y. Qiu, and Q.H. Ji Studies on promoting blood circulation and removing blood stasis of total flavonoids of products from Sparganium stoloniferum Chinese Traditional Patent Medicine 21 1999 511 513
15. T.L. Lu, D.J. Ye, C.Q. Mao, and X.S. Liu Studies on antiplatelet aggregation and antithrombosis action of total flavonoids of Common burreed (Sparganium stoloniferum) Chinese Traditional and Herbal Drugs 30 1999 439 440
16. J.J. Ma, Y. Song, M. Jia, and C.L. Li Effect of total flavone in Sanguis draconis on platelet aggregation, thrombus formation and myocardial ischemia Chinese Traditional and Herbal Drugs 33 2002 1008 1010
17. M.T.L.P. Peres, F. Delle Monache, A.B. Cruz, M.G. Pizzolatti, and R.A. Yunes Chemical composition and antimicrobial activity of Croton urucurana Baillon (Euphorbiaceae) Journal of Ethnopharmacology 56 1997 223 226 (Pubitemid 27271817)
18. V.S. Rao, L.A. Gurgel, R.C. Lima-J'unior, D.T. Martins, V. Cechinel-Filho, and F.A. Santos Dragon's blood from Croton urucurana (Baill.) attenuates visceral nociception in mice Journal of Ethnopharmacology 113 2007 357 360 (Pubitemid 47239256)
19. F.R. Risendaal Risk factors for venous thrombotic disease Thrombosis and Haemostasis 82 1999 610 619
20. Y.Y. Shi, H.B. Xu, F.L. Ji, W. Zhang, F.C. Wen, T. Ding, D.W. Zhang, and X.B. Guo Effects of FU Fang Jiang Ya Pian on blood rheology in blood stasis model rats Chinese Journal of Experimental Traditional Medical Formulae 12 2006 54 55
21. B.B. Vargaftig, M. Chignard, and J. Benveniste Present concepts on the mechanisms of platelet aggregation Biochemical Pharmacology 30 1981 263 271 (Pubitemid 11142601)
22. R. Vink, R.A. Kraaijenhagen, M. Levi, and H.R. Buller Individualized duration of oral anticoagulant therapy for deep vein thrombosis based on a decision model Journal of Thrombosis and Haemostasis 1 2003 2523 2530
23. J. Wei Effect of Xuesaitong on blood pressure and blood rheology in hypertensive patients Journal of Chinese Microcirculation 1 2004 37 38
24. X.X. Xu, L.Z. Xia, J.R. Gao, Q.Y. Liu, and D.Y. Peng Study on antiplatelet effect of Radix astragali total saponin combined with Radix Paeoniae Rubra glucosides Journal of Chinese Medicinal Materials 25 2002 653 655
25. C.X. Yang, S.M. Dai, and G.S. Li Experimental study on effect of Xielongye on blood rheology of rats with extravasated blood and platelet functions of normal rats Guangxi Medical Journal 24 2002 763 764
26. Q.A. Zheng, J.T. Chen, Y.J. Zhang, and C.R. Yang Chemical constituents and physiological activity of famous folk medicine Dragon's Blood Natural Product Research and Development 17 2005 84 95
27. R.S. Zhao, Y.X. Zhang, D.X. Miao, and B. Li Effects of Radix rehmanniae on blood rheology in blood stasis model rats Pharmacology and Clinics of Chinese Materia Medica 22 2006 123
28. Z.H. Zhou, J.L. Wang, and C.R. Yang Chemical constituents of Sanguis draxonis made in China Chinese Traditional and Herbal Drugs 32 2001 484 486
29. H. Zhu, H.B. Huang, and H. Tian A survey of chemical constituents of Sanguis draxonis made in China Journal of Guangxi Traditional Chinese Medical University 5 2002 89 90
30. H. Zhu, Q. Wu, M. Xu, Y.Y. Wu, X.P. Hu, Y.H. Zou, and Y. Yang Effects of total Astragalus extract on anti-thrombus Chinese Journal of Clinical Pharmacology and Therapeutics 10 2005 917 920