Cytokine gene polymorphisms and graft-versus-host disease in children after matched sibling hematopoietic stem cell transplantation: A single-center experience

Cellular and Molecular Immunology

Volumn 8, Issue 3, 2011, Pages 276-280

  Goussetis, Evgenios ^a   Varela, Ioanna ^a   Peristeri, Ioulia ^a   Kitra, Vasiliki ^a   Spanou, Kleopatra ^a   Moraloglou, Olga ^a   Paisiou, Anna ^a   Karatasaki, Sofia ^a   Soldatou, Alexandra ^a   Constantinidou, Nikki ^a   Graphakos, Stelios ^a  

^a AGHIA SOPHIA CHILDREN S HOSPITAL   (Greece)

Author keywords

aGVHD; cytokine gene polymorphisms

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ACUTE GRAFT VERSUS HOST DISEASE; ADOLESCENT; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; CHILD; DISEASE ASSOCIATION; DISEASE SEVERITY; DNA POLYMORPHISM; FEMALE; GENOTYPE; GRAFT VERSUS HOST REACTION; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; MYELOABLATIVE CONDITIONING; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PROMOTER REGION; RETROSPECTIVE STUDY; RISK FACTOR;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; CYTOKINES; GENETIC PREDISPOSITION TO DISEASE; GRAFT VS HOST DISEASE; GREECE; HAPLOTYPES; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HISTOCOMPATIBILITY; HISTOCOMPATIBILITY TESTING; HUMANS; INFANT; POLYMORPHISM, GENETIC; RETROSPECTIVE STUDIES; SIBLINGS; SURVIVAL ANALYSIS; TRANSPLANTATION CONDITIONING;

EID: 79955675485     PISSN: 16727681     EISSN: None     Source Type: Journal    
DOI: 10.1038/cmi.2011.4     Document Type: Article

References (25)

1. Ferrara JL, Levine JE, Reddy P, Holler E. Graft-versus-host-disease. Lancet 2009; 373: 1550-1561.
2. Dickinson AM, Middleton PG, Rocha V, Gluckman E, Holler E. Geneticpolymorphisms predictingtheoutcomeof bone marrowtransplants. Br JHaematol 2004; 127: 479-490.
3. Dickinson AM, Charron D. Non-HLA immunogenetics in hematopoietic stem cell transplantation. Curr Opin Immunol 2005; 17: 517-525. (Pubitemid 41207956)
4. Yilmaz V, Yentur SP, Saruhan-Direskeneli G. IL-12 and IL-10 polymorphisms and their effects on cytokine production. Cytokine 2005;30: 188-194. (Pubitemid 40615967)
5. Holler E, Roncarolo MG, Hintermeier-Knabe R, Eissner G, Ertl B, Schulz U et al. Prognostic significance of increased IL-10 production in patients prior to allogeneic bone marrowtransplantation. Bone Marrow Transplant 2000; 25: 237-241. (Pubitemid 30103011)
6. Middleton PG, Taylor PR, Jackson G, Proctor SJ, Dickinson AM. Cytokine gene polymorphisms associating with severe acute graft-versus-host disease in HLA-identical siblingtransplants. Blood 1998; 92: 3943-3948. (Pubitemid 28525221)
7. Keen LJ, DeFor TE, Bidwell JL, Davies SM, Bradley BA, Hows JM. Interleukin-10 and tumor necrosis factor alpha region haplotypes predict transplant-related mortality afterunrelateddonorstemcelltransplantation. Blood 2004; 103: 3599-3602. (Pubitemid 38525699)
8. Ambruzova Z, Mrazek F, Raida L, Jindra P, Vidan-Jeras B, Faber E et al. Associationof IL-6 and CCL2 gene polymorphisms with the outcome of allogeneic haematopoietic stem cell transplantation. Bone Marrow Transplant 2009; 44: 227-235.
9. Hattori H, Matsuzaki A, Suminoe A, Ihara K, Nagatoshi Y, Sakata N et al. Polymorphisms of growth factor-beta 1 and transforming growth factor-beta 1 type II receptorgenesareassociatedwith acute graft-versus-host disease in children with HLA-matched sibling bone marrowtransplantation. Bone Marrow Transplant 2002; 30:665-671. (Pubitemid 35446648)
10. Goyal RY, Lin Y, Schultz KR, Ferrell RE, Kim Y, Fairfull L et al. Tumornecrosisfactor-c¢ gene polymorphisms are associated with severity of acute graft-versus-host disease following matched unrelated donor bone marrow transplantation in children: A pediatric blood and marrow transplant consortium study. Biol Blood Marrow Transplant 2010; 16: 927-936.
11. Glucksberg H, Storb R, Fefer A, Buckner CD, Neiman PE, Clift RA et al. Cl inical manifestations of graft-versus-host disease in human recipients of marrow from HLA-matched siblingdonors. Transplantation 1974; 18: 295-304.
12. Kubistova Z, Mrazek F, Tudos Z, Kriegova E, Ambruzova Z, Mytilineos J et al. Distribution of 22 cytokine gene polymorphisms in the healthy Czech population. Int J Immunogenet 2006; 33: 261-267. (Pubitemid 44086966)
13. Turner DM, Williams DM, Sankaran D, Lazarus M, Sinnott PG, Hutchinson IV. An investigation of polymorphism in the interleukin-10 gene promoter. Eur J Immunogenet 1997; 24: 1-8. (Pubitemid 27050850)
14. Kurreeman FA, Schonkeren JJ, Heijmans BT, Toes RE, Huizinga TW. Transcription of the IL10 gene reveals allele-specific regulation at the mRNA level. Hum Mol Genet 2004; 13: 1755-1762. (Pubitemid 39173444)
15. Visentainer JE, Lieber SR, Persoli LB, Vigorito AC, Aranha FJ, de Brito Eid KA et al. Serum cytokine levels and acute graft-versus-host disease after HLA-identical hematopoietic stem cell transplantation. Exp Hematol 2003; 31: 1044-1050. (Pubitemid 37329748)
16. Lin MT, Storer B, Martin PJ, Tseng LH, Cooley T, Chen PJ et al. Relation of an interleukin-10 promoter polymorphism to graft-versus-host disease and survival after hematopoietic-cell transplantation. N Engl J Med 2003; 349: 2201-2210. (Pubitemid 37485136)
17. Akdis CA, Blaser K. Mechanisms of interleukin-10-mediated immune suppression. Immunology 2001; 103: 131-136. (Pubitemid 32521341)
18. SociéG, Loiseau P, Tamouza R, Janin A, Bousson M, Gluckman E et al. Both genetic and clinical factors predict the development of graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Transplantation 2001; 72: 699-705.
19. Cavet J, Middleton PG, Segall M, Noreen H, Davies SM, Dickinson AM. Recipient tumour necrosis factor-alpha and interleukin-10 gene polymorphisms associate with early mortality and acute graft-versus-host disease severity in HLA matched sibling bone marrowtransplants. Blood 1999; 98: 3941-3946.
20. Bertinetto FE, Dall'Omo AM, Mazolla GA, Rendine S, Berrino M, Bertola B et al. Roleof non-HLA genetic polymorphisms in graft-versus-host disease after haematopoietic stem cell transplantation. Int J Immunogenet 2006; 33: 375-384. (Pubitemid 44427138)
21. Dickinson AM, Pearce KF, Norden J, O'Brien SG, Holler E, Bickeboeller H et al. Impact of genomic riskfactors on outcomeafter hematopoietic stem cell transplantation for patientswith chronic myeloid leukaemia. Haematologica 2010; 95: 922-927.
22. Bettens F, Passweg J, Gratwohl A, Chalandon Y, Helg C, Chapuis B et al. Associationof TNFd and IL-10 polymorphisms with mortality in unrelated hematopoietic transplantation. Transplantation 2006; 81: 1261-1267. (Pubitemid 43804544)
23. Kim DH, Lee NY, Sohn SK, Baek JH, Kim JG, Suh JS et al. IL-10 promoter gene polymorphism associated with the occurrence of chronic GVHD and its clinical course during systemic immunosuppressive treatment for chronic GVHD after allogeneic peripheral blood stem cell transplantation. Transplantation 2005; 79: 1615-1622. (Pubitemid 40847595)
24. Seo KW, Kim DH, Sohn SK, Lee NY, Chang HH, Kim SW et al. Protective role of interleukin-10 promoter gene polymorphism in the pathogenesis of invasive pulmonary aspergillosis after allogeneic stem cell transplantation. Bone Marrow Transplant 2005; 36: 1089-1095. (Pubitemid 43078138)
25. Attia J, Ioannidis JP, Thakkinstian A, McEvoy M, Scott RJ, Minelli C et al. Howto use an article about genetic association, A: Background concepts. JAMA 2009; 301: 74-81.