Childhood obesity is associated with shorter leukocyte telomere length

Journal of Clinical Endocrinology and Metabolism

Volumn 96, Issue 5, 2011, Pages 1500-1505

  Buxton, Jessica L ^a   Walters, Robin G ^a   Visvikis Siest, Sophie ^b   Meyre, David ^c   Froguel, Philippe ^a,c   Blakemore, Alexandra I F ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITÉ DE LORRAINE   (France)

^c CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; GLUCOSE; GLUCOSE OXIDASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID;

ADOLESCENT; ANTHROPOMETRY; ARTICLE; BODY MASS; CASE CONTROL STUDY; CHILD; CHILDHOOD OBESITY; COHORT ANALYSIS; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DIET RESTRICTION; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; LEUKOCYTE; MAJOR CLINICAL STUDY; MALE; OBESITY; ONSET AGE; PRESCHOOL CHILD; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SCHOOL CHILD; SYSTOLIC BLOOD PRESSURE; TELOMERE;

ADOLESCENT; BLOOD PRESSURE; BODY HEIGHT; BODY WEIGHT; CHILD; CHILD, PRESCHOOL; CHOLESTEROL; CHOLESTEROL, HDL; COHORT STUDIES; DNA; FEMALE; HUMANS; LEUKOCYTES; MALE; OBESITY; PUBERTY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEX CHARACTERISTICS; TELOMERE;

EID: 79955674904     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2010-2924     Document Type: Article

References (40)

1. de Lange T 2005 Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev 19:2100-2110
2. Okuda K, Bardeguez A, Gardner JP, Rodriguez P, Ganesh V, Kimura M, Skurnick J, Awad G, Aviv A 2002 Telomere length in the newborn. Pediatr Res 52:377-381 (Pubitemid 34920268)
3. Chen W, Gardner JP, Kimura M, Brimacombe M, Cao X, Srinivasan SR, Berenson GS, Aviv A 2009 Leukocyte telomere length is associated with HDL cholesterol levels: the Bogalusa heart study. Atherosclerosis 205:620-625
4. Farzaneh-Far R, Lin J, Epel E, Lapham K, Blackburn E, Whooley MA 2010 Telomere length trajectory and its determinants in persons with coronary artery disease: longitudinal findings from the Heart and Soul Study. PLoS ONE 5:e8612
5. von Zglinicki T 2002 Oxidative stress shortens telomeres. Trends Biochem Sci 27:339-344
6. Kurz DJ, Decary S,HongY, Trivier E, Akhmedov A, Erusalimsky JD 2004 Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells. J Cell Sci 117:2417-2426 (Pubitemid 38807508)
7. Aviv A, Valdes AM, Spector TD 2006 Human telomere biology: the pitfalls of moving from the laboratory to epidemiology. Int J Epidemiol 35:1424-1429 (Pubitemid 46178916)
8. Fitzpatrick AL, Kronmal RA, Gardner JP, Psaty BM, Jenny NS, Tracy RP, Walston J, Kimura M, Aviv A 2007 Leukocyte telomere length and cardiovascular disease in the cardiovascular health study. Am J Epidemiol 165:14-21 (Pubitemid 46026204)
9. Brouilette SW, Moore JS., McMahon AD., Thompson JR., Ford Shepherd J, Packard CJ., Samani NJ 2007 Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested case-control study. Lancet 369:107-114 (Pubitemid 46073129)
10. Adaikalakoteswari A, Balasubramanyam M, Mohan V 2005 Telomere shortening occurs in Asian Indian type 2 diabetic patients. Diabet Med 22:1151-1156
11. Sampson MJ, Winterbone MS, Hughes JC, Dozio N, Hughes DA 2006 Monocyte telomere shortening and oxidative DNA damage in type 2 diabetes. Diabetes Care 29:283-289 (Pubitemid 44106505)
12. Boehm BO, Möller P, Högel J, Winkelmann BR, Renner W, Rosinger S, Seelhorst U, Wellnitz B, März W, Melzner J, Brüderlein 2008 Lymphocytes of type 2 diabetic women carry a high load of stable chromosomal aberrations. Diabetes 57:2950-2957
13. Salpea KD, Talmud PJ, Cooper JA, Maubaret CG, Stephens JW, Abelak K, Humphries SE 2010 Association of telomere length with type 2 diabetes, oxidative stress and UCP2 gene variation. Atherosclerosis 209:42-50
14. Gardner JP, Li S, Srinivasan SR, Chen W, Kimura M, Lu X, Berenson GS, Aviv A 2005 Rise in insulin resistance is associated with escalated telomere attrition. Circulation 111:2171-2177 (Pubitemid 40632431)
15. Adaikalakoteswari A, Balasubramanyam M, Ravikumar R, Deepa R, Mohan V 2007 Association of telomere shortening with impaired glucose tolerance and diabetic macroangiopathy. Atherosclerosis 195:83-89
16. Yang Z, Huang X, Jiang H, Zhang Y, Liu H, Qin C, Eisner GM, Jose PA, Jose P, Rudolph L, Ju Z 2009 Short telomeres and prognosis of hypertension in a Chinese population. Hypertension 53:639-645
17. Testa R, Ceriello A 2007 Pathogenetic loop between diabetes and cell senescence. Diabetes Care 30:2974-2975 (Pubitemid 350083156)
18. Aviv A 2009 Leukocyte telomere length, hypertension, and atherosclerosis: are there potential mechanistic explanations? Hypertension 53:590-591
19. World Health Organization 2006 World Health Organization: obesity and overweight fact sheet 2006. Geneva: World Health Organization
20. Walley AJ, Asher JE, Froguel P 2009 The genetic contribution to non-syndromic human obesity. Nat Rev Genet 10:431-442
21. Meyre D, Delplanque J, Chèvre JC, Lecoeur C, Lobbens S, Gallina S, Durand E, Vatin V, Degraeve F, Proença C, Gaget S, Körner A, Kovacs P, Kiess W, Tichet J, Marre M, Hartikainen AL, Horber F, Potoczna N, Hercberg S, Levy-Marchal C, Pattou F, Heude B, Tauber M, McCarthy MI, Blakemore AI, Montpetit A, Polychronakos C, Weill J, Coin LJ, Asher J, Elliott P, Järvelin MR, Visvikis- Siest S, Balkau B, Sladek R, Balding D, Walley A, Dina C, Froguel P 2009 Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat Genet 41:157-159
22. Walters RG, Jacquemont S, Valsesia A, de Smith AJ, Martinet D, Andersson J, Falchi M, Chen F, Andrieux J, Lobbens S, Delobel B, Stutzmann F, El-Sayed Moustafa JS, Chèvre JC, Lecoeur C, Vatin V, Bouquillon S, Buxton JL, Boute O, Holder-Espinasse M, Cuisset JM, Lemaitre MP, Ambresin AE, Brioschi A, Gaillard M, Giusti V, et al. 2010 A new highly penetrant form of obesity due to deletions on chromosome 16p11.2. Nature 463:671-675
23. Valdes AM, Andrew T, Gardner JP, Kimura M, Oelsner E, Cherkas LF, Aviv A, Spector TD 2005 Obesity, cigarette smoking, and telomere length in women. Lancet 366:662-664 (Pubitemid 41176019)
24. Nordfjäll K, Svenson U, Norrback KF, Adolfsson R, Lenner P, Roos G 2009 The individual blood cell telomere attrition rate is telomere length dependent. PLoS Genet 5:e1000375
25. Epel ES, Blackburn EH, Lin J, Dhabhar FS, Adler NE, Morrow JD, Cawthon RM 2004 Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci USA 101:17312-17315
26. Kim S, Parks CG, DeRoo LA, Chen H, Taylor JA, Cawthon RM, Sandler DP 2009 Obesity and weight gain in adulthood and telomere length. Cancer Epidemiol Biomarkers Prev 18:816-820
27. O'Callaghan NJ, Clifton PM, Noakes M, Fenech M 2009 Weight loss in obese men is associated with increased telomere length and decreased abasic sites in rectal mucosa. Rejuvenation Res 12:169-176
28. Zannolli R, Mohn A, Buoni S, Pietrobelli A, Messina M, Chiarelli F, Miracco C 2008 Telomere length and obesity. Acta Paediatr 97:952-954 (Pubitemid 351792805)
29. Al-Attas O, Al-Daghri N, Bamakhramah A, Shaun Sabico S, Mc-Ternan P, Huang TT 2010 Telomere length in relation to insulin resistance, inflammation and obesity among Arab youth. Acta Paediatr 99:896-899
30. Rolland-Cachera MF, Deheger M, Bellisle F 2001 Definition actuelle et evolution de la frequence de l'obesite' chez l'enfant. Cahiers de Nutrition et de Diététique 36:108
31. PoskittEM1995 Defining childhood obesity: the relative body mass index (BMI). Acta Paediatr 84:961-963
32. Visvikis-Siest S, Siest GR 2008 The STANISLAS cohort: a 10-year follow-up of supposed healthy families. Gene-environment interactions, reference values and evaluation of biomarkers in prevention of cardiovascular diseases. Clin Chem Lab Med 46:733-747
33. Meyre D, Boutin P, Tounian A, Deweirder M, Aout M, Jouret B, Heude B, Weill J, Tauber M, Tounian P, Froguel P 2005 Is Glutamate decarboxylase 2 (GAD2) a genetic link between low birth weight and subsequent development of obesity in children? J Clin Endocrinol Metab 90:2384-2390
34. Miller SA, Dykes DD, Polesky HF 1988 A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16:1215
35. Friedewald WT, Levy RI, Fredrickson DS 1972 Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18:499-502
36. Cawthon RM 2009 Telomere length measurement by a novel monochrome multiplex quantitative PCR method. Nucleic Acids Res 37:e21
37. Moreno-Navarrete JM, Ortega F, Sabater M, Ricart W, Fernandez- Real JM 2010 Telomere length of subcutaneous adipose tissue cells is shorter in obese and formerly obese subjects. Int J Obes 34:1345-1348
38. Benetos A, Okuda K, Lajemi M, Kimura M, Thomas F, Skurnick J, Labat C, Bean K, Aviv A 2001 Telomere length as an indicator of biological aging: the gender effect and relation with pulse pressure and pulse wave velocity. Hypertension 37:381-385 (Pubitemid 32198997)
39. Aksglaede L, Juul A, Olsen LW, Sorensen TI 2009 Age at puberty and the emerging obesity epidemic. PLoS ONE 4:e8450
40. Sidorov I, Kimura M, Yashin A, Aviv A 2009 Leukocyte telomere dynamics and human hematopoietic stem cell kinetics during somatic growth. Exp Hematol 37:514-524