A 24-h work shift in intensive care personnel: Biological pathways between work stress and ill health

Journal of International Medical Research

Volumn 39, Issue 2, 2011, Pages 629-636

  Matejovic, M ^a   Chvojka, J ^a   Sykora, R ^a   Krouzecky, A ^a   Radej, J ^a   Parizkova, R ^b   Dostal, P ^b   Novak, I ^a   Cerny, V ^b,c  

^a CHARLES UNIVERSITY   (Czech Republic)

^b UNIVERSITY HOSPITAL HRADEC KRALOVE   (Czech Republic)

^c DALHOUSIE UNIVERSITY   (Canada)

Author keywords

Haemostasis; Inflammatory markers; Microcirculatory blood flow; Tissue factor; Work stress

Indexed keywords

ADIPONECTIN; ANTITHROMBIN; GELATINASE B; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 6; THROMBIN; THROMBOPLASTIN; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1; VON WILLEBRAND FACTOR;

ACUTE STRESS; ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; HEALTH HAZARD; HEALTH STATUS; HEMOSTASIS; HOSPITAL PHYSICIAN; HUMAN; HUMAN EXPERIMENT; INTENSIVE CARE UNIT; JOB STRESS; MALE; MICROCIRCULATION; NORMAL HUMAN; OCCUPATIONAL HEALTH; PROTEIN BLOOD LEVEL; SHIFT WORKER;

EID: 79955664454     PISSN: 03000605     EISSN: None     Source Type: Journal    
DOI: 10.1177/147323001103900232     Document Type: Article

References (26)

1. Parshuram CS, Dhanani S, Kirsh JA, et al: Fellowship training, workload, fatigue and physical stress: a prospective observational study. CMAJ 2004; 170: 965-970.
2. Rosengren A, Hawken S, Ounpuu S, et al: Association of psychosocial risk factors with risk of acute myocardial infarction in 11 119 cases and 13 648 controls from 52 countries (the INTERHEART study): case-control study. Lancet 2004; 364: 953-962.
3. Chandola T, Brunner E, Marmot M: Chronic stress at work and the metabolic syndrome: prospective study. BMJ 2006; 332: 521-525.
4. Chandola T, Britton A, Brunner E, et al: Work stress and coronary heart disease: what are the mechanisms? Eur Heart J 2008; 29: 640-648.
5. Kivimäki M, Leino-Arjas P, Luukkonen R, et al: Work stress and risk of cardiovascular mortality: prospective cohort study of industrial employees. BMJ 2002; 325: 857.
6. Kawachi I, Colditz GA, Stampfer MJ, et al: Prospective study of shift work and risk of coronary heart disease in women. Circulation 1995; 92: 3178-3182.
7. Fujino Y, Iso H, Tamakoshi A, et al: A prospective cohort study of shift work and risk of ischemic heart disease in Japanese male workers. Am J Epidemiol 2006; 164: 128-135.
8. Amir O, Alroy S, Schliamser JE, et al: Brachial artery endothelial function in residents and fellows working night shifts. Am J Cardiol 2004; 93: 947-949.
9. Ghiadoni L, Donald AE, Cropley M, et al: Mental stress induces transient endothelial dysfunction in humans. Circulation 2000; 102: 2473-2478.
10. Von Känel R, Mills PJ, Fainman C, et al: Effects of psychological stress and psychiatric disorders on blood coagulation and fibrinolysis: a biobehavioral pathway to coronary artery disease? Psychosom Med 2001; 63: 531-544.
11. Geiser F, Meier C, Wegener I, et al: Association between anxiety and factors of coagulation and fibrinolysis. Psychother Psychosom 2008; 77: 377-383.
12. Embriaco N, Azoulay E, Barrau K, et al: High level of burnout in intensivists: prevalence and associated factors. Am J Respir Crit Care Med 2007; 175: 686-692.
13. Sapirstein A, Needham DM, Pronovost PJ: 24-hour intensivist staffing: balancing benefits and costs. Crit Care Med 2008; 36: 367-368.
14. De Backer D, Hollenberg S, Boerma C, et al: How to evaluate the microcirculation: report of a round table conference. Crit Care 2007; 11: R101.
15. Butenas S, Orfeo T, Mann KG: Tissue factor activity and function in blood coagulation. Thromb Res 2008; 122(suppl 1): S42-S46.
16. Wallen NH, Goodall AH, Li N, et al: Activation of haemostasis by exercise, mental stress and adrenaline: effects on platelet sensitivity to thrombin and thrombin generation. Clin Sci (Lond) 1999; 97: 27-35.
17. Toker S, Shirom A, Shapira I, et al: The association between burnout, depression, anxiety, and inflammation biomarkers: Creactive protein and fibrinogen in men and women. J Occup Health Psychol 2005; 10: 344-362.
18. Gertow K, Amato M, Werba JP, et al: Tissue factor gene promoter haplotype associates with carotid intima-media thickness in subjects in cardiovascular risk prevention. Atherosclerosis 2009; 207: 168-173.
19. Kittel F, Leynen F, Stam M, et al: Job conditions and fibrinogen in 14 226 Belgian workers: the Belstress study. Eur Heart J 2002; 23: 1841-1848.
20. Theorell T: Job stress and fibrinogen. Eur Heart J 2002; 23: 1799-1801.
21. Hanusch-Enserer U, Zorn G, Wojta J, et al: Nonconventional markers of atherosclerosis before and after gastric banding surgery. Eur Heart J 2009; 30: 1516-1524.
22. Sprague AH, Khalil RA: Inflammatory cytokines in vascular dysfunction and vascular disease. Biochem Pharmacol 2009; 78: 539-552.
23. Ross R: Atherosclerosis-an inflammatory disease. N Engl J Med 1999; 340: 115-126.
24. Strawn WB, Bondjers G, Kaplan JR, et al: Endothelial dysfunction in response to psychosocial stress in monkeys. Circ Res 1991; 68: 1270-1279.
25. 1-adrenoceptor activation. Atherosclerosis 1998; 136: 153-161.
26. Holt E: Doctors in eastern Europe prepare to walk out over pay. Lancet 2010; 376: 221-222.