Ataxin-1 occupies the promoter region of E-cadherin in vivo and activates CtBP2-repressed promoter

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1813, Issue 5, 2011, Pages 713-722

  Lee, Soyeon ^a   Hong, Sunghoi ^a   Kim, Sungsu ^a,b   Kang, Seongman ^a  

^a Korea University   (South Korea)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Activation; Ataxin 1; CtBP2; E cadherin; Repression

Indexed keywords

ATAXIN 1; BINDING PROTEIN; C TERMINAL BINDING PROTEIN 2; LUCIFERASE; MESSENGER RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; UVOMORULIN;

ARTICLE; CELL NUCLEUS; CHROMATIN IMMUNOPRECIPITATION; ENZYME ACTIVITY; FEMALE; GENE REPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN VIVO STUDY; MAMMAL CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; TRANSCRIPTION INITIATION;

ALCOHOL OXIDOREDUCTASES; CADHERINS; CELL LINE, TUMOR; CELL NUCLEUS; HUMANS; MODELS, GENETIC; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN TRANSPORT; REPRESSOR PROTEINS; RNA, MESSENGER; TRANSCRIPTIONAL ACTIVATION;

MAMMALIA;

EID: 79955661923     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2011.01.035     Document Type: Article

References (38)

1. Servadio A., Koshy B., Armstrong D., Antalffy B., Orr H.T., et al. Expression analysis of the ataxin-1 protein in tissues from normal and spinocerebellar ataxia type 1 individuals. Nat. Genet. 1995, 10:94-98.
2. Okazawa H., Rich T., Chang A., Lin X., Waragai M., et al. Interaction between mutant ataxin-1 and PQBP-1 affects transcription and cell death. Neuron 2002, 34:701-713.
3. Matilla A., Koshy B.T., Cummings C.J., Isobe T., Orr H.T., et al. The cerebellar leucine-rich acidic nuclear protein interacts with ataxin-1. Nature 1997, 389:974-978.
4. Cvetanovic M., Rooney R.J., Garcia J.J., Toporovskaya N., Zoghbi H.Y., et al. The role of LANP and ataxin 1 in E4F-mediated transcriptional repression. EMBO Rep. 2007, 8:671-677.
5. Tsai C.C., Kao H.Y., Mitzutani A., Banayo E., Rajan H., et al. Ataxin 1, a SCA1 neurodegenerative disorder protein, is functionally linked to the silencing mediator of retinoid and thyroid hormone receptors. Proc. Natl Acad. Sci. USA 2004, 101:4047-4052.
6. Goold R., Hubank M., Hunt A., Holton J., Menon R.P., et al. Down-regulation of the dopamine receptor D2 in mice lacking ataxin 1. Hum. Mol. Genet. 2007, 16:2122-2134.
7. Schaeper U., Boyd J.M., Verma S., Uhlmann E., Subramanian T., et al. Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation. Proc. Natl Acad. Sci. USA 1995, 92:10467-10471.
8. Brannon M., Brown J.D., Bates R., Kimelman D., Moon R.T. XCtBP is a XTcf-3 co-repressor with roles throughout Xenopus development. Development 1999, 126:3159-3170.
9. Izutsu K., Kurokawa M., Imai Y., Maki K., Mitani K., et al. The corepressor CtBP interacts with Evi-1 to repress transforming growth factor beta signaling. Blood 2001, 97:2815-2822.
10. Melhuish T.A., Wotton D. The interaction of the carboxyl terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF. J. Biol. Chem. 2000, 275:39762-39766.
11. Dressel U., Bailey P.J., Wang S.C., Downes M., Evans R.M., et al. A dynamic role for HDAC7 in MEF2-mediated muscle differentiation. J. Biol. Chem. 2001, 276:17007-17013.
12. Zhang C.L., McKinsey T.A., Lu J.R., Olson E.N. Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor. J. Biol. Chem. 2001, 276:35-39.
13. Hildebrand J.D., Soriano P. Overlapping and unique roles for C-terminal binding protein 1 (CtBP1) and CtBP2 during mouse development. Mol. Cell. Biol. 2002, 22:5296-5307.
14. Grooteclaes M., Deveraux Q., Hildebrand J., Zhang Q., Goodman R.H., et al. C-terminal-binding protein corepresses epithelial and proapoptotic gene expression programs. Proc. Natl Acad. Sci. USA 2003, 100:4568-4573.
15. Shi Y., Sawada J., Sui G., Affar el B., Whetstine J.R., et al. Coordinated histone modifications mediated by a CtBP co-repressor complex. Nature 2003, 422:735-738.
16. Zhao L.J., Kuppuswamy M., Vijayalingam S., Chinnadurai G. Interaction of ZEB and histone deacetylase with the PLDLS-binding cleft region of monomeric C-terminal binding protein 2. BMC Mol. Biol. 2009, 10:89.
17. Fernandez-Funez P., Nino-Rosales M.L., de Gouyon B., She W.C., Luchak J.M., et al. Identification of genes that modify ataxin-1-induced neurodegeneration. Nature 2000, 408:101-106.
18. Alpatov R., Munguba G.C., Caton P., Joo J.H., Shi Y., et al. Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene. Mol. Cell. Biol. 2004, 24:10223-10235.
19. Choi D., Lee S.J., Hong S., Kim I.H., Kang S. Prohibitin interacts with RNF2 and regulates E2F1 function via dual pathways. Oncogene 2008, 27:1716-1725.
20. Hong S., Lee S., Cho S.G., Kang S. UbcH6 interacts with and ubiquitinates the SCA1 gene product ataxin-1. Biochem. Biophys. Res. Commun. 2008, 371:256-260.
21. Aparicio O., Geisberg J.V., Sekinger E., Yang A., Moqtaderi Z., et al. Chromatin immunoprecipitation for determining the association of proteins with specific genomic sequences in vivo. Curr. Protoc. Mol. Biol. 2005, Chapter 21: Unit 21 23.
22. Guaita S., Puig I., Franci C., Garrido M., Dominguez D., et al. Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression. J. Biol. Chem. 2002, 277:39209-39216.
23. Peiro S., Escriva M., Puig I., Barbera M.J., Dave N., et al. Snail1 transcriptional repressor binds to its own promoter and controls its expression. Nucleic Acids Res. 2006, 34:2077-2084.
24. Wang S., Zhang B., Faller D.V. Prohibitin requires Brg-1 and Brm for the repression of E2F and cell growth. EMBO J. 2002, 21:3019-3028.
25. Geisberg J.V., Struhl K. Analysis of protein co-occupancy by quantitative sequential chromatin immunoprecipitation. Curr. Protoc. Mol. Biol. 2005, Chapter 21: Unit 21 28.
26. Geisberg J.V., Struhl K. Quantitative sequential chromatin immunoprecipitation, a method for analyzing co-occupancy of proteins at genomic regions in vivo. Nucleic Acids Res. 2004, 32:e151.
27. Lee S., Hong S., Kang S. The ubiquitin-conjugating enzyme UbcH6 regulates the transcriptional repression activity of the SCA1 gene product ataxin-1. Biochem. Biophys. Res. Commun. 2008, 372:735-740.
28. Batlle E., Sancho E., Franci C., Dominguez D., Monfar M., et al. The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat. Cell Biol. 2000, 2:84-89.
29. Nibu Y., Zhang H., Levine M. Interaction of short-range repressors with Drosophila CtBP in the embryo. Science 1998, 280:101-104.
30. Weigert R., Silletta M.G., Spano S., Turacchio G., Cericola C., et al. CtBP/BARS induces fission of Golgi membranes by acylating lysophosphatidic acid. Nature 1999, 402:429-433.
31. Criqui-Filipe P., Ducret C., Maira S.M., Wasylyk B. Net, a negative Ras-switchable TCF, contains a second inhibition domain, the CID, that mediates repression through interactions with CtBP and de-acetylation. EMBO J. 1999, 18:3392-3403.
32. Chinnadurai G. CtBP, an unconventional transcriptional corepressor in development and oncogenesis. Mol. Cell 2002, 9:213-224.
33. Peinado H., Ballestar E., Esteller M., Cano A. Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex. Mol. Cell. Biol. 2004, 24:306-319.
34. Chinnadurai G. Transcriptional regulation by C-terminal binding proteins. Int. J. Biochem. Cell Biol. 2007, 39:1593-1607.
35. Comijn J., Berx G., Vermassen P., Verschueren K., van Grunsven L., et al. The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion. Mol. Cell 2001, 7:1267-1278.
36. Lin X., Antalffy B., Kang D., Orr H.T., Zoghbi H.Y. Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA1. Nat. Neurosci. 2000, 3:157-163.
37. Shimamura K., Hirano S., McMahon A.P., Takeichi M. Wnt-1-dependent regulation of local E-cadherin and alpha N-catenin expression in the embryonic mouse brain. Development 1994, 120:2225-2234.
38. Shimamura K., Takeichi M. Local and transient expression of E-cadherin involved in mouse embryonic brain morphogenesis. Development 1992, 116:1011-1019.