Decreased motility of the lower esophageal sphincter in a rat model of gastroesophageal reflux disease may be mediated by reductions of serotonin and acetylcholine signaling

Biological and Pharmaceutical Bulletin

Volumn 34, Issue 5, 2011, Pages 704-711

  Saegusa, Yayoi ^a,b   Takeda, Hiroshi ^a,c   Muto, Shuichi ^c,d   Oridate, Nobuhiko ^c   Nakagawa, Koji ^a   Sadakane, Chiharu ^a,b   Nahata, Miwa ^b   Harada, Yumi ^b   Iizuka, Mizuki ^b   Hattori, Tomohisa ^b   Asaka, Masahiro ^c  

^a HOKKAIDO UNIVERSITY   (Japan)

^b TSUMURA AND CO   (Japan)

^c HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d Tomakomai City General Hospital   (Japan)

Author keywords

Acetylcholine; Gastroesophageal reflux disease; Lower esophageal sphincter; Motility; Rat; Serotonin

Indexed keywords

ACETYLCHOLINE; ATROPINE; CISAPRIDE; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC M4 RECEPTOR; SEROTONIN; SEROTONIN 2A RECEPTOR; SEROTONIN 2B RECEPTOR; SEROTONIN 2C RECEPTOR; SEROTONIN 4 RECEPTOR; SEROTONIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ESOPHAGUS DISEASE; ESOPHAGUS EROSION; ESOPHAGUS MOTILITY; FORCE TRANSDUCER; GASTROESOPHAGEAL REFLUX; GENE EXPRESSION; IN VIVO STUDY; INTRACELLULAR SIGNALING; LOWER ESOPHAGUS SPHINCTER; MALE; NONHUMAN; RAT; SEROTONINERGIC TRANSMISSION; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE RELAXATION;

ACETYLCHOLINE; ANIMALS; DISEASE MODELS, ANIMAL; ESOPHAGEAL SPHINCTER, LOWER; GASTROESOPHAGEAL REFLUX; MALE; RATS; RATS, WISTAR; SEROTONIN; SIGNAL TRANSDUCTION;

EID: 79955653572     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.34.704     Document Type: Article

References (16)

1. Richter J. E., Best Pact. Res. Clin. Gastroenterol., 21, 609-631 (2007).
2. Meneghetti A. T., Tedesco P., Damani T., Patti M. G., J. Gastrointest. Surg., 9, 1313-1317 (2005).
3. De Giorgi F., Palmiero M., Esposito I., Mosca F., Cuomo R., Acta Otorhinolaryngol. Ital., 26, 241-246 (2006).
4. Grossi L., Spezzaferro M., Sacco L. F., Marzio L., Neurogastroenterol. Motil., 20, 760-766 (2008).
5. Lu W. Y., Bieger D., Am. J. Physiol., 274 R1436-R1445 (1998).
6. Takeuchi T., Nakamura A., Nakajima H., Azuma Y. T., Hata F., Eur. J. Pharmacol., 537, 155-159 (2006).
7. Boeckxstaens G. E., Neurogastroenterol. Motil., 17 (Suppl. 1), 13-21 (2005).
8. Gonzalez A. A., Farre R., Clave P., Am. J. Physiol. Gastrointest. Liver Physiol., 287, G299-G306 (2004).
9. Ponti F. D., Gut, 53, 1520-1535 (2004).
10. Omura N., Kashiwagi H., Chen G., Suzuki Y., Yano F., Aoki T., Scand. J. Gastroenterol., 34, 948-953 (1999).
11. Ouatu-Lascar R., Lin O. S., Fitzgerald R. C., Triadafilopoulos G., J. Gastroenterol. Hepatol., 16, 1184-1190 (2001).
12. Feniuk W., Humphrey P. P. A., Perren M. J., Watts A. D., Br. J. Pharmacol., 86, 697-704 (1985).
13. Miwa H., Oshima T., Sakurai J., Tomita T., Matsumoto T., Iizuka S., Koseki J., Neurogastroenterol. Motil., 21, 296-303 (2009).
14. Miwa H., Koseki J., Oshima T., Kondo T., Tomita T., Watari J., Matsumoto T., Hattori T., Kubota K., Iizuka S., J. Gastrol., 45, 478-487 (2010).
15. Norum J. H., Hart K., Levy F. O., J. Biol. Chem., 278, 3098-3104 (2003).
16. Pehlivanov N., Sarosiek I., Whitman R., Olyaee M., McCallum R., Aliment Pharmacol. Ther., 16, 743-747 (2002).