Dendritic cells treated with HPV16mE7 in a three-dimensional model promote the secretion of IL-12p70 and IFN-γ

Experimental and Molecular Pathology

Volumn 91, Issue 1, 2011, Pages 325-330

  Wang, Ya Ting ^a   Li, WenSheng ^a   Liu, QinShe ^a   Guan, XiaoYing ^a   Hu, Jun ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Dendritic cell; HPVE7 vaccine; Immune; Three dimensional

Indexed keywords

B7 ANTIGEN; CD40 ANTIGEN; CD48 ANTIGEN; COLLAGEN GEL; DNA VACCINE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 4; PROTEIN E7;

ANIMAL CELL; ARTICLE; CELL STRUCTURE; CELLULAR IMMUNITY; COCULTURE; CONTROLLED STUDY; CULTURE TECHNIQUE; CYTOKINE RELEASE; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; E7 GENE; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMAN PAPILLOMAVIRUS TYPE 16; IMMUNE RESPONSE; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; LYMPHOCYTE PROLIFERATION; MOLECULAR CLONING; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; ONCOGENE; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; RAT; SITE DIRECTED MUTAGENESIS;

ANIMALS; BONE MARROW CELLS; CELLS, CULTURED; CLONING, MOLECULAR; CULTURE TECHNIQUES; DENDRITIC CELLS; HUMAN PAPILLOMAVIRUS 16; HUMANS; IMAGING, THREE-DIMENSIONAL; INTERFERON-GAMMA; INTERLEUKIN-12; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; PAPILLOMAVIRUS E7 PROTEINS; T-LYMPHOCYTES; TRANSFECTION; VACCINES, DNA;

HUMAN PAPILLOMAVIRUS;

EID: 79955651981     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2011.03.005     Document Type: Article

References (23)

1. Bekeredjian-Ding I., Roth S.I., Gilles S., Giese T., Ablasser A., Hornung V., Endres S., Hartmann G. T cell-independent, TLR-induced IL-12p70 production in primary human monocytes. J. Immunol. 2006, 176(2006):7438-7446.
2. Bellone S., El-Sahwi K., Cocco E., Casagrande F., Cargnelutti M., Palmieri M., Bignotti E., Romani C., Silasi D.A., Azodi M., Schwartz P.E., Rutherford T.J., Pecorelli S., Santin A.D. Human papillomavirus type 16 (HPV-16) virus-like particle L1-specific CD8+ cytotoxic T lymphocytes (CTLs) are equally effective as E7-specific CD8+ CTLs in killing autologous HPV-16-positive tumor cells in cervical cancer patients: implications for L1 dendritic cell-based therapeutic vaccines. J. Virol. 2009, 83(2009):6779-6789.
3. Bermudez-Morales V.H., Gutierrez L.X., Alcocer-Gonzalez J.M., Burguete A., Madrid-Marina V. Correlation between IL-10 gene expression and HPV infection in cervical cancer: a mechanism for immune response escape. Cancer Invest. 2008, 26(2008):1037-1043.
4. Bhairavabhotla R.K., Verm V., Tongaonkar H., Shastri S., Dinshaw K., Chiplunkar S. Role of IL-10 in immune suppression in cervical cancer. Indian J. Biochem. Biophys. 2007, 44(2007):350-356.
5. Bolpetti A., Silva J.S., Villa L.L., Lepique A.P., Bolpetti A., et al. Interleukin-10 production by tumor infiltrating macrophages plays a role in human papillomavirus 16 tumor growth. BMC Immunol. 2010, 7(11):27.
6. Davidson E.J., Brown M.D., Burt D.J., Parish J.L., Gaston K., Kitchener H.C., Stacey S.N., Stern P.L. Human T cell responses to HPV 16 E2 generated with monocyte-derived dendritic cells. Int. J. Cancer 2001, 94(2001):807-812.
7. de Witte L., Zoughlami Y., Aengeneyndt B., David G., van Kooyk Y., Gissmann L., Geijtenbeek T.B. Binding of human papilloma virus L1 virus-like particles to dendritic cells is mediated through heparan sulfates and induces immune activation. Immunobiology 2007, 212(2007):679-691.
8. Delneste Y., Charbonnier P., Herbault N., Magistrelli G., Caron G., Bonnefoy J.Y., Jeannin P. Interferon-gamma switches monocyte differentiation from dendritic cells to macrophages. Blood 2003, 101(2003):143-150.
9. Gunzer M., Friedl P., Niggemann B., Bröcker E.B., Kämpgen E., Zänker K.S. Migration of dendritic cells within 3-D collagen lattices is dependent on tissue origin, state of maturation, and matrix structure and is maintained by proin-flammatory cytokines. J. Leukoc. Biol. 2000, 67(2000):622-629.
10. Hung C.F., Yang M., Wu T.C. Modifying professional antigen-presenting cells to enhance DNA vaccine potency. Methods Mol. Med. 2006, 127(2006):199-220.
11. Kim S.H., Hur Y.J., Lee S.J., Kim S.J., Park C.G., Oh Y.K., Jung W.W., Seo J.B., Nam M.H., Choi I., Chun T. E6 and E7 fusion immunoglobulin from human papilloma virus 16 induces dendritic cell maturation and antigen specific activation of T helper 1 response. Biotechnol. Lett. 2011, 33(2011):663-671.
12. Lenz P., Day P.M., Pang Y.Y., Frye S.A., Jensen P.N., Lowy D.R., Schiller J.T. Papillomavirus-like particles induce acute activation of dendritic cells. J. Immunol. 2001, 166(2001):5346-5355.
13. Lenz P., Lowy D.R., Schiller J.T. Papillomavirus virus-like particles induce cytokines characteristic of innate immune responses in plasmacytoid dendritic cells. Eur. J. Immunol. 2005, 35(2005):1548-1556.
14. Monie A., Tsen S.W., Hung C.F., Wu T.C. Therapeutic HPV DNA vaccines. Expert Rev. Vaccines 2009, 8(2009):1221-1235.
15. Nieto K., Gissmann L., Schädlich L. Human papillomavirus-specific immune therapy: failure and hope. Antivir. Ther. 2010, 15(2010):951-957.
16. Olsson S.E., Villa L.L., Costa R.L., Petta C.A., Andrade R.P., Malm C., Iversen O.E., Høye J., Steinwall M., Riis-Johannessen G., Andersson-Ellstrom A., Elfgren K., von Krogh G., Lehtinen M., Paavonen J., Tamms G.M., Giacoletti K., Lupinacci L., Esser M.T., Vuocolo S.C., Saah A.J., Barr E. Induction of immune memory following administration of a prophylactic quadrivalent human papillomavirus (HPV) types 6/11/16/18 L1 virus-like particle (VLP) vaccine. Vaccine 2007, 25(2007):4931-4939.
17. Palucka K., Ueno H., Fay J., Banchereau J. Dendritic cells and immunity against cancer. J. Intern. Med. 2011, 269(2011):64-73.
18. Radulovic S., Brankovic-Magic M., Malisic E., Jankovic R., Dobricic J., Plesinac-Karapandzic V., Maciag P.C., Rothman J. Therapeutic cancer vaccines in cervical cancer: phase I study of Lovaxin-C. J. BUON. 2009, 14(2009):165-168.
19. Rakesh M., Austyn J.M. Bacterial lipopolysaccharide contamination of commercial collagen preparations may mediate dendritic cell maturation in culture. J. Immunol. Methods 1998, 214(1998):149-163.
20. Santin A.D., Hermonat P.L., Ravaggi A., Chiriva-Internati M., Zhan D., Pecorelli S., Parham G.P., Cannon M.J. Induction of human papillomavirus-specific CD4+ and CD8+ lymphocytes by E7-pulsed autologous dendritic cells in patients with human papillomavirus type 16- and 18-positive cervical cancer. J. Virol. 1999, 73(1999):5402-5410.
21. Syrjänen S., Naud P., Sarian L., Derchain S., Roteli-Martins C., Longatto-Filho A., Tatti S., Branca M., Erzen M., Hammes L.S., Costa S., Syrjänen K. Immunosuppressive cytokine Interleukin-10 (IL-10) is up-regulated in high-grade CIN but not associated with high-risk human papillomavirus (HPV) at baseline, outcomes of HR-HPV infections or incident CIN in the LAMS cohort. Virchows Arch. 2009, 455(2009):505-515.
22. Tasaki A., Yamanaka N., Kubo M., Matsumoto K., Kuroki H., Nakamura K., Nakahara C., Onishi H., Kuga H., Baba E., Tanaka M., Morisaki T., Katano M. Three-dimensional two-layer collagen matrix gel culture model for evaluating complex biological functions of monocyte-derived dendritic cells. J. Immunol. Methods 2004, 287(2004):79-90.
23. Yin R., Zheng W., Hao F., Yang X.C., Zhong B.Y., Li Q.J. HPV16E7 tumor antigen modified by KDEL sequence induce specific cytotoxic T lymphocytes-dependent antitumor immunity. J. Dermatol. Sci. 2009, 55(2009):116-122.