The chromogranin A- derived N-terminal peptide vasostatin-I: In vivo effects on cardiovascular variables in the rabbit

Regulatory Peptides

Volumn 168, Issue 1-3, 2011, Pages 10-20

  Roatta, Silvestro ^a   Passatore, Magda ^a   Novello, Matteo ^a   Colombo, Barbara ^b   Dondossola, Eleonora ^b   Mohammed, Mazher ^a   Losano, Gianni ^a   Corti, Angelo ^b   Helle, Karen B ^c  

^a Cardiology Medical School   (Italy)

^b San Raf faele Institute   (Italy)

^c UNIVERSITY OF BERGEN   (Norway)

Author keywords

Adrenergic blockades; Conscious animal; Ganglion blockade; Sympathetic nervous system; Vasoconstriction; Vasodilatation

Indexed keywords

ALPHA ADRENERGIC RECEPTOR; AMINO TERMINAL TELOPEPTIDE; CHROMOGRANIN A; HEXAMETHONIUM; KETAMINE; NORADRENALIN; PEPTIDE; PHENTOLAMINE; PROPRANOLOL; UNCLASSIFIED DRUG; VASOSTATIN I; XYLAZINE;

ADRENERGIC RECEPTOR BLOCKING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GANGLION BLOCK; HEART HEMODYNAMICS; IMMUNOREACTIVITY; IN VIVO STUDY; MALE; NONHUMAN; NORADRENALIN RELEASE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; RABBIT; SYMPATHETIC NERVE; VASOCONSTRICTION; VASODILATATION;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; CARDIOVASCULAR PHYSIOLOGICAL PROCESSES; CHROMOGRANIN A; HUMANS; MALE; PEPTIDE FRAGMENTS; PROPRANOLOL; RABBITS; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; VASOCONSTRICTION;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 79955648504     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.regpep.2011.02.015     Document Type: Article

References (43)

1. Helle K.B., Corti A., Metz-Boutigue M.H., Tota B. The endocrine role for chromogranin A: a prohormone for peptides with regulatory properties. Cell Mol Life Sci 2007, 64:2863-2886.
2. Sciola V., Massironi S., Conte D., Caprioli F., Ferrero S., Ciafardini C., Peracchi M., Bardella M.T., Piodi L. Plasma chromogranin a in patients with inflammatory bowel disease. Inflamm Bowel Dis 2009, 15:867-871.
3. Helle K.B. The chromogranin A-derived peptides vasostatin-I and catestatin as regulatory peptides for cardiovascular functions. Cardiovasc Res 2010, 85:9-16.
4. Helle K.B. Regulatory peptides from chromogranin A and secretogranin II: Putative modulators of cells and tissues involved in inflammatory conditions. Regul Pept 2010, 165:45-51.
5. Belloni D., Scabini S., Foglieni C., Veschini L., Giazzon A., Colombo B., Fulgenzi A., Helle K.B., Ferrero M.E., Corti A., Ferrero E. The vasostatin-I fragment of chromogranin A inhibits VEGF-induced endothelial cell proliferation and migration. FASEB J 2007, 21:3052-3062.
6. Theurl M., Schgoer W., Albrecht K., Jeschke J., Egger M., Beer A.G., Vasiljevic D., Rong S., Wolf A.M., Bahlmann F.H., Patsch J.R., Wolf D., Schratzberger P., Mahata S.K., Kirchmair R. The neuropeptide catestatin acts as a novel angiogenic cytokine via a basic fibroblast growth factor-dependent mechanism. Circ Res 2010, 107:1326-1335.
7. Helle K.B., Marley P.D., Angeletti R.H., Aunis D., Galindo E., Small D.H., Livett B.G. Chromogranin A: secretion of processed products from the stimulated retrogradely perfused bovine adrenal gland. J Neuroendocrinol 1993, 5:413-420.
8. Metz-Boutigue M.H., Garcia-Sablone P., Hogue-Angeletti R., Aunis D. Intracellular and extracellular processing of chromogranin A. Determination of cleavage sites. Eur J Biochem 1993, 217:247-257.
9. Aardal S., Helle K.B. The vasoinhibitory activity of bovine chromogranin A fragment (vasostatin) and its independence of extracellular calcium in isolated segments of human blood vessels. Regul Pept 1992, 41:9-18.
10. Corti A., Mannarino C., Mazza R., Colombo B., Longhi R., Tota B. Vasostatins exert negative inotropism in the working heart of the frog. Ann NY Acad Sci 2002, 971:362-365.
11. Tota B., Mazza R., Angelone T., Nullans G., Metz-Boutigue M.H., Aunis D., Helle K.B. Peptides from the N-terminal domain of chromogranin A (vasostatins) exert negative inotropic effects in the isolated frog heart. Regul Pept 2003, 114:123-130.
12. Imbrogno S., Angelone T., Corti A., Adamo C., Helle K.B., Tota B. Influence of vasostatins, the chromogranin A-derived peptides, on the working heart of the eel (Anguilla anguilla): negative inotropy and mechanism of action. Gen Comp Endocrinol 2004, 139:20-28.
13. Corti A., Mannarino C., Mazza R., Angelone T., Longhi R., Tota B. Chromogranin A N-terminal fragments vasostatin-1 and the synthetic CGA 7-57 peptide act as cardiostatins on the isolated working frog heart. Gen Comp Endocrinol 2004, 136:217-224.
14. Cerra M.C., De Iuri L., Angelone T., Corti A., Tota B. Recombinant N-terminal fragments of chromogranin-A modulate cardiac function of the Langendorff-perfused rat heart. Basic Res Cardiol 2006, 101:43-52.
15. Cerra M.C., Gallo M.P., Angelone T., Quintieri A.M., Pulera E., Filice E., Guerold B., Shooshtarizadeh P., Levi R., Ramella R., Brero A., Boero O., Metz-Boutigue M.H., Tota B., Alloatti G. The homologous rat chromogranin A1-64 (rCGA1-64) modulates myocardial and coronary function in rat heart to counteract adrenergic stimulation indirectly via endothelium-derived nitric oxide. FASEB J 2008, 22:3992-4004.
16. Cappello S., Angelone T., Tota B., Pagliaro P., Penna C., Rastaldo R., Corti A., Losano G., Cerra M.C. Human recombinant chromogranin A-derived vasostatin-1 mimics preconditioning via an adenosine/nitric oxide signaling mechanism. Am J Physiol Heart Circ Physiol 2007, 293:H719-H727.
17. Gallo M.P., Levi R., Ramella R., Brero A., Boero O., Tota B., Alloatti G. Endothelium-derived nitric oxide mediates the antiadrenergic effect of human vasostatin-1 in rat ventricular myocardium. Am J Physiol Heart Circ Physiol 2007, 292:H2906-H2912.
18. Roatta S., Mohammed M., Passatore M. Acute stress reduces blood flow in the orofacial area, in conscious rabbits. Arch Oral Biol 2009, 54:380-388.
19. Roatta S., Windhorst U., Djupsjobacka M., Lytvynenko S., Passatore M. Effects of sympathetic stimulation on the rhythmical jaw movements produced by electrical stimulation of the cortical masticatory areas of rabbits. Exp Brain Res 2005, 162:14-22.
20. Roatta S., Deriu F., Artusio E., Passatore M. A simple, non-invasive and inexpensive method for evaluating the displacement of local tissue surfaces: from vascular changes to muscle contraction. Clin Physiol 1996, 16:83-94.
21. Ceconi C., Ferrari R., Bachetti T., Opasich C., Volterrani M., Colombo B., Parrinello G., Corti A. Chromogranin A in heart failure; a novel neurohumoral factor and a predictor for mortality. Eur Heart J 2002, 23:967-974.
22. Corti A., Sanchez L.P., Gasparri A., Curnis F., Longhi R., Brandazza A., Siccardi A.G., Sidoli A. Production and structure characterisation of recombinant chromogranin A N-terminal fragments (vasostatins) - evidence of dimer-monomer equilibria. Eur J Biochem 1997, 248:692-699.
23. Ratti S., Curnis F., Longhi R., Colombo B., Gasparri A., Magni F., Manera E., Metz-Boutigue M.H., Corti A. Structure-activity relationships of chromogranin A in cell adhesion. Identification of an adhesion site for fibroblasts and smooth muscle cells. J Biol Chem 2000, 275:29257-29263.
24. Nalivaiko E., Ootsuka Y., Blessing W.W. Activation of 5-HT1A receptors in the medullary raphe reduces cardiovascular changes elicited by acute psychological and inflammatory stresses in rabbits. Am J Physiol Regul Integr Comp Physiol 2005, 289:R596-R604.
25. Capra N.F. Localization and central projections of primary afferent neurons that innervate the temporomandibular joint in cats. Somatosens Res 1987, 4:201-213.
26. Kohn A. Die Paraganglien. Arch Mikr Anat 1903, 62:263-365.
27. Coupland R.E. The natural history of the chromaffin cell 1965, 253. Longmans, UK.
28. Høkfelt B., McLean L. The adrenaline and noradrenaline content of the suprarenal glands of the rabbit under normal conditions and after various forms of stimulation. Acta Physiol Scand 1950, 21:258-270.
29. Hillarp Å., Høkfelt B. Evidence of adrenaline and noradrenaline in separate adrenal medullary cells. Acta Physiol Scand 1953, 30:55-68.
30. Eränkö O. Distribution of adrenaline and noradrenaline in the adrenal medulla. Nat Lond 1955, 175:88-89.
31. Roatta S., Mohammed M., Passatore M. Detecting activation of the sympathetic-adrenal axis from hemodynamic recordings, in conscious rabbits exposed to acute stress. Acta Physiol (Oxf) 2011, 201:323-337.
32. Hjemdahl P. Plasma catecholamines-analytical challenges and physiological limitations. Baillières Clin Endocrinol Metab 1993, 7:307-353.
33. Brekke J.F., Osol G.J., Helle K.B. N-terminal chromogranin-derived peptides as dilators of bovine coronary resistance arteries. Regul Pept 2002, 105:93-100.
34. Blois A., Srebro B., Mandala M., Corti A., Helle K.B., Serck-Hanssen G. The chromogranin A peptide vasostatin-I inhibits gap formation and signal transduction mediated by inflammatory agents in cultured bovine pulmonary and coronary arterial endothelial cells. Regul Pept 2006, 135:78-84.
35. Mott J.C. The relation of blood volume to body weight and arterial haemoglobin levels in rabbits. J Physiol Lond 1967, 191:131-140.
36. Hsiao R.J., Neumann H.P., Parmer R.J., Barbosa J.A., O'Connor D.T. Chromogranin A in familial pheochromocytoma: diagnostic screening value, prediction of tumor mass, and post-resection kinetics indicating two-compartment distribution. Am J Med 1990, 88:607-613.
37. Stridsberg M., Angeletti R.H., Helle K.B. Characterisation of N-terminal chromogranin A and chromogranin B in mammals by region-specific radioimmunoassays and chromatographic separation methods. J Endocrinol 2000, 165:703-714.
38. Oi K., Yamada Y. Noxious stimulation reduces blood pressure but not flow in the internal carotid artery as measured in rabbits. Anesth Prog 1990, 37:24-28.
39. Sahu B.S., Sonawane P.J., Mahapatra N.R. Chromogranin A: a novel susceptibility gene for essential hypertension. Cell Mol Life Sci 2010, 67:861-874.
40. Angelone T., Quintieri A.M., Brar B.K., Limchaiyawat P.T., Tota B., Mahata S.K., Cerra M.C. The antihypertensive chromogranin a peptide catestatin acts as a novel endocrine/paracrine modulator of cardiac inotropism and lusitropism. Endocrinology 2008, 149:4780-4793.
41. Blois A., Holmsen H., Martino G., Corti A., Metz-Boutigue M.H., Helle K.B. Interactions of chromogranin A-derived vasostatins and monolayers of phosphatidylserine, phosphatidylcholine and phosphatidylethanolamine. Regul Pept 2006, 134:30-37.
42. Ramella R., Boero O., Alloatti G., Angelone T., Levi R., Gallo M.P. Vasostatin 1 activates eNOS in endothelial cells through a proteoglycan-dependent mechanism. J Cell Biochem 2010, 110:70-79.
43. Dondossola E., Gasparri A., Bachi A., Longhi R., Metz-Boutigue M.H., Tota B., Helle K.B., Curnis F., Corti A. Role of vasostatin-1 C-terminal region in fibroblast cell adhesion. Cell Mol Life Sci 2010, 67:2107-2118.