Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: A randomised, placebo-controlled, phase 3 trial
Navarra, S. V. et al. Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial. Lancet 377, 721-731 (2011).
Belimumab, a BLyS-specific inhibitor, reduced disease activity across multiple organ domains: Combined efficacy results from the phase 3 BLISS-52 and -76 studies [abstract 1456]
Manzi, S. et al. Belimumab, a BLyS-specific inhibitor, reduced disease activity across multiple organ domains: combined efficacy results from the phase 3 BLISS-52 and -76 studies [abstract 1456]. Arthritis Rheum. 62 (Suppl.), S607 (2010).
US Food and Drug Administration. FDA approves Benlysta to treat lupus [online], http:// www.fda.gov/NewsEvents/Newsroom/Press Announcements/ucm246489. htm (2011).
A phase II, randomized, double-blind, placebo-controlled, dose-ranging study of belimumab in patients with active systemic lupus erythematosus
Wallace, D. J. et al. A phase II, randomized, double-blind, placebo-controlled, dose-ranging study of belimumab in patients with active systemic lupus erythematosus. Arthritis Rheum. 61, 1168-1178 (2009).
Targeting BLyS in rheumatic disease: The sometimes-bumpy road from bench to bedside
doi:10.1097/ BOR.0b013e328344c15e
Stohl, W., Scholz, J. L. & Cancro, M. P. Targeting BLyS in rheumatic disease: the sometimes-bumpy road from bench to bedside. Curr. Opin. Rheumatol. doi:10.1097/ BOR.0b013e328344c15e.
Effect of long-term belimumab treatment on B cells in systemic lupus erythematosus: Extension of a phase II, double-blind, placebo-controlled, dose-ranging study
Jacobi, A. M. et al. Effect of long-term belimumab treatment on B cells in systemic lupus erythematosus: extension of a phase II, double-blind, placebo-controlled, dose-ranging study. Arthritis Rheum. 62, 201-210 (2010).
CD19+CD24hiCD38hi B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic lupus erythematosus patients
Blair, P. A. et al. CD19+CD24hiCD38hi B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic lupus erythematosus patients. Immunity 32, 129-140 (2010).
Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells
Iwata, Y. et al. Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells. Blood 117, 530-541 (2011).