Transient lower oesophageal sphincter relaxation reducers - Have we hit a brick wall?

Alimentary Pharmacology and Therapeutics

Volumn 33, Issue 11, 2011, Pages 1256-1257

  Hershcovici, T ^a   Fass, R ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADX 10059; GASTROINTESTINAL AGENT; LESOGABERAN; METABOTROPIC RECEPTOR ANTAGONIST; PLACEBO; PROTON PUMP INHIBITOR; UNCLASSIFIED DRUG;

DIZZINESS; DRUG EFFICACY; DRUG TREATMENT FAILURE; GASTROESOPHAGEAL REFLUX; HUMAN; LETTER; LOWER ESOPHAGUS SPHINCTER; PRIORITY JOURNAL; SLEEP DISORDER; SMOOTH MUSCLE RELAXATION; SYMPTOM; TREATMENT DURATION; TREATMENT RESPONSE; VERTIGO;

ESOPHAGEAL SPHINCTER, LOWER; ESOPHAGOGASTRIC JUNCTION; GASTROESOPHAGEAL REFLUX; GASTROINTESTINAL MOTILITY; HUMANS; MUSCLE RELAXATION; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RECEPTORS, METABOTROPIC GLUTAMATE;

EID: 79955630418     PISSN: 02692813     EISSN: 13652036     Source Type: Journal    
DOI: 10.1111/j.1365-2036.2011.04632.x     Document Type: Letter

References (3)

1. Zerbib F, Bruley des Varannes S, Roman S, et al. Randomised clinical trial: effects of monotherapy with ADX10059, a mGluR5 inhibitor, on symptoms and reflux events in patients with gastro-oesophageal reflux disease. Aliment Pharmacol Ther 2011; 33: 911-21.
2. Boeckxstaens GE, Beaumont H, Mertens V, et al. Effects of lesogaberan on reflux and lower esophageal sphincter function in patients with gastroesophageal reflux disease. Gastroenterology 2010; 139: 409-17.
3. Gerson LB, Huff FJ, Hila A, et al. Arbaclofen placarbil decreases postprandial reflux in patients with gastroesophageal reflux disease. Am J Gastroenterol 2010; 105: 1266-75.