Greatwall, a new guardian of mitosis;Greatwall, un nouveau gardien de la mitose

Medecine/Sciences

Volumn 27, Issue 4, 2011, Pages 352-354

  Gharbi Ayachi, Aicha ^a   Burgess, Andrew ^a   Vigneron, Suzanne ^a   Labbé, Jean Claude ^a   Castro, Anna ^a   Lorca, Thierry ^a  

^a Centre National de la Recherche Scientifique   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; CYCLIC AMP REGULATED PHOSPHOPROTEIN 19; CYCLIC AMP-REGULATED PHOSPHOPROTEIN 19; CYCLIN B; CYCLIN DEPENDENT KINASE 1; DROSOPHILA PROTEIN; ENDOSULFINE; GREATWALL PROTEIN, DROSOPHILA; PEPTIDE; PHOSPHOPROTEIN; PHOSPHOPROTEIN PHOSPHATASE 2; PROTEIN SERINE THREONINE KINASE;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; DRUG ANTAGONISM; ENZYME SPECIFICITY; HUMAN; MITOSIS; NUCLEOTIDE SEQUENCE; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN PROCESSING;

ANIMALS; CDC2 PROTEIN KINASE; CELL CYCLE PROTEINS; CONSERVED SEQUENCE; CYCLIN B; DROSOPHILA PROTEINS; HUMANS; MITOSIS; MODELS, BIOLOGICAL; PEPTIDES; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN PHOSPHATASE 2; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN-SERINE-THREONINE KINASES; SUBSTRATE SPECIFICITY;

EID: 79955628191     PISSN: 07670974     EISSN: None     Source Type: Journal    
DOI: 10.1051/medsci/2011274006     Document Type: Article

References (11)

1. Jackson PK.. Climbing the Greatwall to mitosis. Mol Cell 2006; 22: 156-157.
2. Yu J, Fleming SL, Williams B, et al. Greatwall kinase: a nuclear protein required for proper chromosome condensation and mitotic progression in Drosophila. J Cell Biol 2004; 164: 487-492. (Pubitemid 38233309)
3. Yu J, Zhao Y, Li Z, et al. Greatwall kinase participates in the Cdc2 autoregulatory loop in Xenopus egg extracts. Mol Cell 2006; 22: 83-91.
4. Vigneron S, Brioudes E, Burgess A, et al. Greatwall maintains mitosis through regulation of PP2A. EMBO J 2009; 28: 2786-2793.
5. Castilho PV, Williams BC, Mochida S, et al. The M phase kinase Greatwall (Gwl) promotes inactivation of PP2A/B55delta, a phosphatase directed against CDK phosphosites. Mol Biol Cell 2009; 20: 4777-4789.
6. Burgess A, Vigneron S, Brioudes E, et al. Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B Cdc2/PP2A balance. Proc Natl Acad Sci USA 2010; 107: 12564-12569.
7. Von Stetina JR, Tranguch S, Dey SK, et al. Alpha-Endosulfine is a conserved protein required for oocyte meiotic maturation in Drosophila. Development 2008; 35: 3697-3706.
8. Lorca T, Bernis C, Vigneron S, et al. Constant regulation of the MPF amplification loop and of the Greatwall/PP2A pathway is required for metaphase II-arrest and for a correct entry into first embryonic cell cycle. J Cell Sci 2010; 123: 2281-2291.
9. Gharbi-Ayachi A, Labbé JC, Burgess A, et al. The Greatwall substrate Arpp19 controls mitosis by inhibiting PP2A. Science 2010; 17: 1673-1677.
10. Mochida S, Maslen SL, Skehel M, et al. Greatwall phosphorylates an inhibitor of protein phosphatase 2A that is essential for mitosis. Science 2010; 17: 1670-1673.
11. Dorée M. Le déclenchement de la mitose chez les eucaryotes supérieurs. Med Sci Paris 2003; 19: 299-307. (Pubitemid 36323351)