Orexin/hypocretin receptor chimaeras reveal structural features important for orexin peptide distinction

FEBS Letters

Volumn 585, Issue 9, 2011, Pages 1368-1374

  Putula, Jaana ^a   Turunen, Pauli M ^a   Johansson, Lisa ^b   Näsman, Johnny ^c   Ra, Runar ^a   Korhonen, Laura ^d   Kukkonen, Jyrki P ^a,b,d  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UPPSALA UNIVERSITY   (Sweden)

^c ÅBO AKADEMI UNIVERSITY   (Finland)

^d MINERVA FOUNDATION INSTITUTE FOR MEDICAL RESEARCH   (Finland)

Author keywords

Calcium; Hypocretin; Orexin; Orexin A; Orexin B

Indexed keywords

CALCIUM ION; OREXIN 1 RECEPTOR; OREXIN 2 RECEPTOR; OREXIN A; OREXIN B;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL STRAIN HEK293; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN STRUCTURE; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; BINDING SITES; DOSE-RESPONSE RELATIONSHIP, DRUG; HEK293 CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; NEUROPEPTIDES; PROTEIN ISOFORMS; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROPEPTIDE; RECOMBINANT FUSION PROTEINS;

CHIMAERIFORMES;

EID: 79955628185     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2011.04.020     Document Type: Article

References (17)

1. L. de Lecea The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity Proc. Natl. Acad. Sci. USA 95 1998 322 327 (Pubitemid 28103952)
2. T. Sakurai Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior Cell 92 1998 573 585 (Pubitemid 28101119)
3. R.M. Chemelli Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation Cell 98 1999 437 451 (Pubitemid 29402482)
4. L. Lin The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene Cell 98 1999 365 376 (Pubitemid 29380571)
5. S. Nishino, B. Ripley, S. Overeem, G.J. Lammers, and E. Mignot Hypocretin (orexin) deficiency in human narcolepsy Lancet 355 2000 39 40 (Pubitemid 30072183)
6. J.P. Kukkonen, T. Holmqvist, S. Ammoun, and K.E. kerman Functions of the orexinergic/hypocretinergic system Am. J. Physiol. Cell. Physiol. 283 2002 C1567 C1591
7. B. Boutrel, P.J. Kenny, S.E. Specio, R. Martin-Fardon, A. Markou, G.F. Koob, and L. de Lecea Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior Proc. Natl. Acad. Sci. USA 102 2005 19168 19173 (Pubitemid 43049584)
8. G.C. Harris, M. Wimmer, and G. Aston-Jones A role for lateral hypothalamic orexin neurons in reward seeking Nature 437 2005 556 559 (Pubitemid 41613553)
9. A.J. Roecker, and P.J. Coleman Orexin receptor antagonists: medicinal chemistry and therapeutic potential Curr. Top. Med. Chem. 8 2008 977 987
10. J.G. Darker, R.A. Porter, D.S. Eggleston, D. Smart, S.J. Brough, C. Sabido-David, and J.C. Jerman Structure-activity analysis of truncated orexin-A analogues at the orexin-1 receptor Bioorg. Med. Chem. Lett. 11 2001 737 740 (Pubitemid 32187967)
11. T. Okumura Requirement of intact disulfide bonds in orexin-A-induced stimulation of gastric acid secretion that is mediated by OX1 receptor activation Biochem. Biophys. Res. Commun. 280 2001 976 981 (Pubitemid 32924434)
12. S. Ammoun, T. Holmqvist, R. Shariatmadari, H.B. Oonk, M. Detheux, M. Parmentier, K.E. kerman, and J.P. Kukkonen Distinct recognition of OX1 and OX2 receptors by orexin peptides J. Pharmacol. Exp. Ther. 305 2003 507 514 (Pubitemid 36459164)
13. S. Asahi, S. Egashira, M. Matsuda, H. Iwaasa, A. Kanatani, M. Ohkubo, M. Ihara, and H. Morishima Development of an orexin-2 receptor selective agonist, [Ala(11),d-Leu(15)]orexin-B Bioorg. Med. Chem. Lett. 13 2003 111 113 (Pubitemid 35447695)
14. J. Putula, P.M. Turunen, M.H. Jäntti, M.E. Ekholm, and J.P. Kukkonen Agonist ligand discrimination by the two orexin receptors depends on the expression system Neurosci. Lett. 494 2011 57 60
15. M. Hungs, J. Fan, L. Lin, X. Lin, R.A. Maki, and E. Mignot Identification and functional analysis of mutations in the hypocretin (orexin) genes of narcoleptic canines Genome Res. 11 2001 531 539 (Pubitemid 32331550)
16. P. Malherbe, O. Roche, A. Marcuz, C. Kratzeisen, J.G. Wettstein, and C. Bissantz Mapping the binding pocket of dual antagonist almorexant to human orexin 1 and orexin 2 receptors: comparison with the selective OX1 (SB-674042) and OX2 (EMPA) antagonists Mol. Pharmacol. 78 2010 81 93
17. J.P. Kukkonen Regulation of receptor-coupling to (multiple) G-proteins. A challenge for basic research and drug discovery Receptors Channels 10 2004 167 183 (Pubitemid 40778697)