The effects of IL-28B and ITPA polymorphisms on treatment of hepatitis C virus genotype 6

American Journal of Gastroenterology

Volumn 106, Issue 5, 2011, Pages 1007-1008

  Seto, Wai Kay ^a   Tanaka, Yasuhito ^b   Liu, Kevin ^a   Lai, Ching Lung ^a   Yuen, Man Fung ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

INOSINE TRIPHOSPHATE; INTERLEUKIN 28B; PEGINTERFERON ALPHA2A; PEGINTERFERON ALPHA2B; RIBAVIRIN;

ADULT; AGED; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG DOSE REDUCTION; FEMALE; GENE LOCUS; GENETIC ASSOCIATION; GENOTYPE; HEMOLYTIC ANEMIA; HEPATITIS C VIRUS; HUMAN; LETTER; MALE; PREDICTOR VARIABLE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT DURATION; TREATMENT RESPONSE;

ADOLESCENT; ADULT; AGED; ANTIVIRAL AGENTS; FEMALE; GENOTYPE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; INTERFERON ALFA-2A; INTERLEUKINS; MALE; MIDDLE AGED; POLYETHYLENE GLYCOLS; POLYMORPHISM, SINGLE NUCLEOTIDE; PYROPHOSPHATASES; RIBAVIRIN; YOUNG ADULT;

EID: 79955618321     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1038/ajg.2011.40     Document Type: Letter

References (5)

1. Clark PJ, Thompson AJ, McHutchison JG. IL28B genomic-based treatment paradigms for patients with chronic hepatitis c infection: the future of personalized HCV therapies. Am J Gastroenterol 2011; 106: 38-45.
2. Fellay J, Thompson AJ, Ge D et al. ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C. Nature 2010; 464: 405-8.
3. Akkarathamrongsin S, Sugiyama M, Matsuura K et al. High sensitivity assay using serum sample for IL28B genotyping to predict treatment response in chronic hepatitis C patients. Hepatol Res 2010; 40: 956-962.
4. Sakamoto N, Tanaka Y, Nakagawa M et al. ITPA gene variant protects against anemia induced by pegylated interferon-alpha and ribavirin therapy for Japanese patients with chronic hepatitis C. Hepatol Res 2010; 40: 1063-1071.
5. Lam KD, Trinh HN, Do ST et al. Randomized controlled trial of pegylated interferon-alfa 2a and ribavirin in treatment-naive chronic hepatitis C genotype 6. Hepatology 2010; 52: 1573-1580.