Profiling sterols in cerebrotendinous xanthomatosis: Utility of Girard derivatization and high resolution exact mass LC-ESI-MSn analysis

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 17-18, 2011, Pages 1384-1392

  DeBarber, Andrea E ^a   Sandlers, Yana ^b   Pappu, Anuradha S ^a   Merkens, Louise S ^a   Duell, P Barton ^a   Lear, Steven R ^c   Erickson, Sandra K ^c,d   Steiner, Robert D ^e  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b KENNEDY KRIEGER INSTITUTE   (United States)

^c SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Bile alcohols; Derivatization; FTMS; Genetic disorders; Keto sterols; LC ESI MSn; Multi stage CID fragmentation

Indexed keywords

BILE ALCOHOLS; DERIVATIZATIONS; FTMS; GENETIC DISORDERS; KETO STEROLS; LC-ESI-MSN; MULTI-STAGE;

BODY FLUIDS; CHEMICAL REACTIONS; CHLORINE COMPOUNDS; CHOLESTEROL; GENES; LIPIDS; MASS SPECTROMETRY; NEURODEGENERATIVE DISEASES; PLASMAS;

ALCOHOLS;

3 OXO 4 ENE; 3 OXO 5(H); CHOLEST 4 EN 3 ONE; CHOLESTANETRIOL 26 MONOOXYGENASE; CHOLESTEROL; HYDRAZONE DERIVATIVE; STEROL; UNCLASSIFIED DRUG;

ADOLESCENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILE ACID METABOLISM; CEREBROTENDINOUS XANTHOMATOSIS; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENZYME DEFECT; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; PLASMA; PRIORITY JOURNAL; SAMPLE;

ANIMALS; CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 CYP27A1; FEMALE; HUMANS; MALE; MASS SPECTROMETRY; MICE; MICE, KNOCKOUT; STEROLS; XANTHOMATOSIS, CEREBROTENDINOUS;

MUS;

EID: 79955617129     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2010.11.019     Document Type: Article

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