Variability in total testosterone levels in ageing men with symptoms of androgen deficiency

International Journal of Andrology

Volumn 34, Issue 3, 2011, Pages 212-216

  Allan, C A ^a,b   Strauss, B J G ^b,c   Forbes, E A ^a   Paul, E ^b   McLachlan, R I ^a,b  

^a HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c MONASH MEDICAL CENTRE   (Australia)

Author keywords

Ageing; Andropause; Testosterone

Indexed keywords

ADULT; AGING; ANDROGEN DEFICIENCY; ARTICLE; COHORT ANALYSIS; HUMAN; MAJOR CLINICAL STUDY; MALE; MEASUREMENT; PREDICTION; PRIORITY JOURNAL; SYMPTOM; TESTOSTERONE BLOOD LEVEL;

AGED; AGED, 80 AND OVER; AGING; ANDROGENS; COHORT STUDIES; HUMANS; HYPOGONADISM; MALE; MIDDLE AGED; TESTOSTERONE;

EID: 79955611741     PISSN: 01056263     EISSN: 13652605     Source Type: Journal    
DOI: 10.1111/j.1365-2605.2010.01071.x     Document Type: Article

References (17)

1. Allan CA, Strauss BJ, Burger HG, Forbes EA and McLachlan RI. (2008) Testosterone therapy prevents gain in visceral adipose tissue and loss of skeletal muscle in nonobese aging men. J Clin Endocrinol Metab 93, 139-146.
2. Araujo AB, Esche GR, Kupelian V, O'Donnell AB, Travison TG, Williams RE et al. (2007) Prevalence of symptomatic androgen deficiency in men. J Clin Endocrinol Metab 92, 4241-4247.
3. Araujo AB, O'Donnell AB, Brambilla DJ, Simpson WB, Longcope C, Matsumoto AM et al. (2004) Prevalence and incidence of androgen deficiency in middle-aged and older men: estimates from the Massachusetts Male Aging Study. J Clin Endocrinol Metab 89, 5920-5926.
4. Bhasin S, Cunningham GR, Hayes FJ, Matsumoto AM, Snyder PJ, Swerdloff RS and Montori VM. (2006) Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 91, 1995-2010.
5. Brambilla DJ, McKinlay SM, McKinlay JB, Weiss SR, Johannes CB, Crawford SL and Longcope C. (1996) Does collecting repeated blood samples from each subject improve the precision of estimated steroid hormone levels? J Clin Epidemiol 49, 345-350.
6. Brambilla DJ, O'Donnell AB, Matsumoto AM and McKinlay JB. (2007a) Intraindividual variation in levels of serum testosterone and other reproductive and adrenal hormones in men. Clin Endocrinol (Oxf) 67, 853-862.
7. Brambilla DJ, O'Donnell AB, Matsumoto AM and McKinlay JB. (2007b) Lack of seasonal variation in serum sex hormone levels in middle-aged to older men in the Boston area. J Clin Endocrinol Metab 92, 4224-4229.
8. Bremner WJ, Vitiello MV and Prinz PN. (1983) Loss of circadian rhythmicity in blood testosterone levels with aging in normal men. J Clin Endocrinol Metab 56, 1278-1281.
9. Conway AJ, Handelsman DJ, Lording DW, Stuckey B, Zajac JD. (2000) Use, misuse and abuse of androgens. The Endocrine Society of Australia consensus guidelines for androgen prescribing. Med J Aust 172, 220-224.
10. Diver MJ, Imtiaz KE, Ahmad AM, Vora JP and Fraser WD. (2003) Diurnal rhythms of serum total, free and bioavailable testosterone and of sHbg in middle-aged men compared with those in young men. Clin Endocrinol (Oxf) 58, 710-717.
11. Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman MR. (2001) Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. J Clin Endocrinol Metab 86, 724-731.
12. Morley JE, Patrick P and Perry HM, III. (2002) Evaluation of assays available to measure free testosterone. Metabolism 51, 554-559.
13. Nieschlag E, Swerdloff R, Behre HM, Gooren LJ, Kaufman JM, Legros JJ et al. (2005) Investigation, treatment and monitoring of late-onset hypogonadism in males: ISA, ISSAM, and EAU recommendations. Int J Androl 28, 125-127.
14. Sikaris K, McLachlan RI, Kazlauskas R, de Kretser D, Holden CA and Handelsman DJ. (2005) Reproductive hormone reference intervals for healthy fertile young men: evaluation of automated platform assays. J Clin Endocrinol Metab 90, 5928-5936.
15. Swerdloff RS, Wang C, Cunningham G, Dobs A, Iranmanesh A, Matsumoto AM, Snyder PJ, Weber T, Longstreth J and Berman N. (2000) Long-term pharmacokinetics of transdermal testosterone gel in hypogonadal men. J Clin Endocrinol Metab 85, 4500-4510.
16. Vermeulen A and Verdonck G. (1992) Representativeness of a single point plasma testosterone level for the long term hormonal milieu in men. J Clin Endocrinol Metab 74, 939-942.
17. Wang C, Nieschlag E, Swerdloff R, Behre HM, Hellstrom WJ, Gooren LJ et al. (2009) Investigation, treatment and monitoring of late-onset hypogonadism in males. Int J Androl 32, 1-10.