Sudden acute leukemia transformation in a MDS patient with del(5q) in complete cytogenetic remission after lenalidomide

Leukemia Research

Volumn 35, Issue 6, 2011, Pages

  Breccia, Massimo ^a   Cannella, Laura ^a   Latagliata, Roberto ^a   Nanni, Mauro ^a   Santopietro, Michelina ^a   Loglisci, Giuseppina ^a   Ferretti, Antonietta ^a   Barzotti, Rita ^a   Oliva, Esther N ^b   Alimena, Giuliana ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b BIANCHI MELACRINO MORELLI HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AZACITIDINE; ERYTHROPOIETIN; LENALIDOMIDE;

5Q- SYNDROME; ACUTE GRANULOCYTIC LEUKEMIA; AGED; BONE MARROW EXAMINATION; CASE REPORT; CHROMOSOME ANALYSIS; DRUG RESPONSE; DRUG WITHDRAWAL; ERYTHROCYTE TRANSFUSION; FATIGUE; HUMAN; LETTER; MACROCYTIC ANEMIA; MALE; MALIGNANT TRANSFORMATION; NEUTROPENIA; PRIORITY JOURNAL; REMISSION; THROMBOCYTOPENIA;

ACUTE DISEASE; AGED; ANTINEOPLASTIC AGENTS; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 5; HUMANS; LEUKEMIA, MYELOID; MALE; MYELODYSPLASTIC SYNDROMES; SPECTRAL KARYOTYPING; THALIDOMIDE;

EID: 79955607659     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2010.12.019     Document Type: Letter

References (4)

1. Komrokji R.S., Lancet J.E., List A.F. Lenalidomide in myelodysplastic syndromes: an erythropoiesis-stimulating agent or more?. Curr Hematol Malign Rep 2010, 5:9-14.
2. Gohring G., Giagounidis A., Busche G., Kreipe H.H., Zimmermann M., Hellstrom-Lindberg E., et al. Patients with del(5q) MDS who fail to achieve sustained erythroid or cytogenetic remission after treatment with lenalidomide have an increased risk for clonal evolution and AML progression. Ann Hematol 2010, 89:365-374.
3. List A., Dewald G., Bennett J., Giagounidis A., Raza A., Feldman E., et al. Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion. N Engl J Med 2006, 355:1456-1465.
4. List A.F. Immunomodulatory drugs in myelodysplastic syndromes: long-term outcome. Hematol Educ 2008, 2:91-94.