Are hypnotic benzodiazepine receptor agonists teratogenic in humans?

Journal of Clinical Psychopharmacology

Volumn 31, Issue 3, 2011, Pages 356-359

  Wikner, Birgitta Norstedt ^a   Källén, Bengt ^b  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF LUND   (Sweden)

Author keywords

congenital malformations; hypnotic benzodiazepine receptor agonists; pregnancy

Indexed keywords

BENZODIAZEPINE RECEPTOR STIMULATING AGENT; CITALOPRAM; CLEMASTINE; FLUPENTIXOL; INSULIN; PAROXETINE; PROPIOMAZINE; PSYCHOTROPIC AGENT; THYROXINE; ZALEPLON; ZOLPIDEM; ZOPICLONE;

ARTICLE; CHILDLESSNESS; CLEFT LIP; CONGENITAL MALFORMATION; CONTROLLED STUDY; FEMALE; FIRST TRIMESTER PREGNANCY; HUMAN; HYPOSPADIAS; INFANT; INSOMNIA; INTESTINE ATRESIA; INTESTINE DUPLICATION; INTESTINE STENOSIS; MAJOR CLINICAL STUDY; MATERNAL SMOKING; MEGACOLON; PARITY; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; REGISTER; SPONTANEOUS ABORTION; TERATOGENICITY;

ABNORMALITIES, DRUG-INDUCED; ACETAMIDES; ADULT; AZABICYCLO COMPOUNDS; CONGENITAL ABNORMALITIES; FEMALE; GABA-A RECEPTOR AGONISTS; HUMANS; HYPNOTICS AND SEDATIVES; INFANT, NEWBORN; MALE; MIDDLE AGED; PARTURITION; PIPERAZINES; PREGNANCY; PYRIDINES; PYRIMIDINES; REGISTRIES; SWEDEN;

EID: 79955597670     PISSN: 02710749     EISSN: 1533712X     Source Type: Journal    
DOI: 10.1097/JCP.0b013e3182197055     Document Type: Article

References (18)

1. Sullivan SS, Guilleminault C. Emerging drugs for insomnia: new frontiers for old and novel targets. Expert Opin Emerg Drugs. 2009;14:411-422.
2. Dolovich LR, Addis A, Vaillancourt JM, et al. Benzodiazepine use in pregnancy and major malformations or oral clefts: meta-analysis of cohort and case-control studies. Br Med J. 1998;317:839-843. (Pubitemid 28434551)
3. Eros E, Czeizel AE, Rockenbauer M, et al. A population-based case-control teratologic study of nitrazepam, medazepam, tofisopam, alprazolum and clonazepam treatment during pregnancy. Eur J Obstet Gynaecol Reprod Biol. 2002;101:147-154. (Pubitemid 34163261)
4. Laegreid L, Olegärd R, Walström J, et al. Teratogenic effects of benzodiazepine use during pregnancy. J Pediatr. 1989;114:126-131. (Pubitemid 19027756)
5. Laegreid L, Olegärd R, Conradi N, et al. Congenital malformations and maternal consumption of benzodiazepines: a case-control study. Dev Med Child Neurol. 1990;32:432-441. (Pubitemid 20179604)
6. Wikner BN, Stiller CO, Bergman U, et al. Use of benzodiazepines and benzodiazepine receptor agonists during pregnancy: neonatal outcome and congenital malformations. Pharmacoepidemiol Drug Saf. 2007;16:1203-1210. (Pubitemid 350120645)
7. Diav-Citrin O, Okotore B, Lucarelli K, et al. Pregnancy outcome following first-trimester exposure to zoplicone: a prospective controlled cohort study. Am J Perinatal. 1999;16:157-160. (Pubitemid 29379968)
8. Wilton LV, Pearce GL, Martin RM, et al. The outcomes of pregnancy in women exposed to newly marketed drugs in general practice in England. Br J Obstet Gynaecol. 1998;105:882-889. (Pubitemid 28423505)
9. Juric S, Newport DJ, Ritchie JC, et al. Zolpidem (Ambien) in pregnancy: placenta passage and outcome. Arch Womens Ment Health. 2009;12:441-446.
10. Wikner BN, Stiller CO, Källén B, et al. Use of benzodiazepines and benzodiazepine receptor agonists during pregnancy: maternal characteristics. Pharmacoepidemiol Drug Saf. 2007;16:988-994. (Pubitemid 47422847)
11. National Board of Health and Welfare. The Swedish Medical Birth RegisterVA summary of content and quality. Available at: http://www. socialstyrelsen.se/Publikationer2003/2003-112-3. Accessed September 23, 2009.
12. National Board of Health and Welfare. Registration of congenital malformations in Swedish health registers. Available at: http://www. socialstyrelsen.se/Publikationer2004/2004-112-1. Accessed May 12, 2009.
13. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959;22:719-748.
14. Miettinen OS. Simple interval estimation of risk ratio. Am J Epidemiol. 1974;100:515-516.
15. Reis M, Källén B. Delivery outcome after maternal use of antidepressant drugs in pregnancy: an update using Swedish data. Psychol Med. 2010;40:1723-1733.
16. Källén B. Use of antihistamine drugs in early pregnancy and delivery outcome. J Matern Neonatal Med. 2002;11:146-152. (Pubitemid 34836924)
17. Reis M, Källén B. Maternal use of antipsychotics in early pregnancy and delivery outcome. J Clin Psychopharmacol. 2008;28: 279-288.
18. Iyer CP, Mahour GH. Duplications of the alimentary tract in infants and children. J Pediatr Surg. 1995;30:1267-1270. (Pubitemid 26063480)