The C76R transmembrane activator and calcium modulator cyclophilin ligand interactor mutation disrupts antibody production and B-cell homeostasis in heterozygous and homozygous mice

Journal of Allergy and Clinical Immunology

Volumn 127, Issue 5, 2011, Pages 1253-1259.e13

  Bacchelli, Chiara ^a   Buckland, Karen F ^a   Buckridge, Sylvie ^a   Salzer, Ulrich ^b   Schneider, Pascal ^c   Thrasher, Adrian J ^a,d   Gaspar, H Bobby ^a,d  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF FREIBURG   (Germany)

^c UNIVERSITY OF LAUSANNE   (Switzerland)

^d GREAT ORMOND STREET HOSPITAL   (United Kingdom)

Author keywords

a proliferation inducing ligand; B cell; common variable immunodeficiency; Hypogammaglobulinemia; lymphoproliferation; primary immunodeficiency; transmembrane activator and calcium modulator cyclophilin ligand

Indexed keywords

APRIL PROTEIN; CD40 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN M; INTERLEUKIN 4; T LYMPHOCYTE ANTIGEN; TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; B LYMPHOCYTE; CELL LINEAGE; CELL SURFACE; COMMON VARIABLE IMMUNODEFICIENCY; CONTROLLED STUDY; EMBRYO; GENE EXPRESSION; GENE MUTATION; GENE TARGETING; HETEROZYGOTE; HOMEOSTASIS; HOMOZYGOTE; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; IMMUNOGLOBULIN PRODUCTION; IN VITRO STUDY; LIGAND BINDING; MAJOR CLINICAL STUDY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; WILD TYPE;

EID: 79955589621     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2011.02.037     Document Type: Article

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