Treatment Strategies for Sarcopenia and Frailty

Medical Clinics of North America

Volumn 95, Issue 3, 2011, Pages 427-438

  Rolland, Yves ^a,b   Dupuy, Charlotte ^a,b   Abellan van Kan, Gabor ^a,b   Gillette, Sophie ^a,b   Vellas, Bruno ^a,b  

^a INSERM   (France)

^b CHU PURPAN   (France)

Author keywords

Creatine; Frailty; Physical activity; Sarcopenia; Testosterone; Vitamin D; Weight loss

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ESTROGEN; GROWTH HORMONE; PLACEBO; SELECTIVE ANDROGEN RECEPTOR MODULATOR; TESTOSTERONE; TIBOLONE;

ARTHRALGIA; CALORIC INTAKE; CARDIOVASCULAR SYMPTOM; DIABETES MELLITUS; DIETARY INTAKE; EDEMA; FRAIL ELDERLY; GYNECOMASTIA; HUMAN; IMMOBILIZATION; MUSCLE ATROPHY; NUTRITIONAL VALUE; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PROTEIN INTAKE; RESISTANCE TRAINING; REVIEW;

ACCIDENTAL FALLS; AGED; ANTIOXIDANTS; DIETARY PROTEINS; EXERCISE; FRAIL ELDERLY; GERIATRIC ASSESSMENT; HEALTH PROMOTION; HUMANS; LIFE STYLE; MUSCLE WEAKNESS; PROTEIN-ENERGY MALNUTRITION; RESISTANCE TRAINING; SARCOPENIA;

EID: 79955581626     PISSN: 00257125     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mcna.2011.02.008     Document Type: Review

References (107)

1. Rockwood K., Stadnyk K., MacKnight C., et al. A brief clinical instrument to classify frailty in elderly people. Lancet 1999, 353:205.
2. Fried L.P., Tangen C.M., Walston J., et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001, 56:M146.
3. Bortz W.M. The physics of frailty. J Am Geriatr Soc 1993, 41:1004.
4. Lipsitz L.A., Goldberger A.L. Loss of 'complexity' and aging. Potential applications of fractals and chaos theory to senescence. JAMA 1992, 267:1806.
5. Gill T.M., Gahbauer E.A., Allore H.G., et al. Transitions between frailty states among community-living older persons. Arch Intern Med 2006, 166:418.
6. Walston J., Fried L.P. Frailty and the older man. Med Clin North Am 1999, 83:1173.
7. Janssen I., Baumgartner R.N., Ross R., et al. Skeletal muscle cutpoints associated with elevated physical disability risk in older men and women. Am J Epidemiol 2004, 159:413.
8. Abellan van Kan G., Rolland Y., Andrieu S., et al. Gait speed at usual pace as a predictor of adverse outcomes in community-dwelling older people an International Academy on Nutrition and Aging (IANA) Task Force. J Nutr Health Aging 2009, 13:881.
9. Nguyen T., Sambrook P., Kelly P., et al. Prediction of osteoporotic fractures by postural instability and bone density. BMJ 1993, 307:1111.
10. Cooper R., Kuh D., Hardy R. Objectively measured physical capability levels and mortality: systematic review and meta-analysis. BMJ 2010, 341:c4467.
11. Studenski S., Perera S., Patel K., et al. Gait speed and survival in older adults. JAMA 2011, 305:50.
12. Janssen I., Shepard D.S., Katzmarzyk P.T., et al. The healthcare costs of sarcopenia in the United States. J Am Geriatr Soc 2004, 52:80.
13. Morley J.E., Argiles J.M., Evans W.J., et al. Nutritional recommendations for the management of sarcopenia. J Am Med Dir Assoc 2010, 11:391.
14. Vanitallie T.B. Frailty in the elderly: contributions of sarcopenia and visceral protein depletion. Metabolism 2003, 52:22.
15. Rolland Y., Kim M.J., Gammack J.K., et al. Office management of weight loss in older persons. Am J Med 2006, 119:1019.
16. Cornali C., Franzoni S., Frisoni G.B., et al. Anorexia as an independent predictor of mortality. J Am Geriatr Soc 2005, 53:354.
17. Cornoni-Huntley J.C., Harris T.B., Everett D.F., et al. An overview of body weight of older persons, including the impact on mortality. The National Health and Nutrition Examination Survey I-Epidemiologic Follow-up Study. J Clin Epidemiol 1991, 44:743.
18. Ensrud K.E., Ewing S.K., Stone K.L., et al. Intentional and unintentional weight loss increase bone loss and hip fracture risk in older women. J Am Geriatr Soc 2003, 51:1740.
19. Payette H., Coulombe C., Boutier V., et al. Nutrition risk factors for institutionalization in a free-living functionally dependent elderly population. J Clin Epidemiol 2000, 53:579.
20. Rubenstein L.Z., Harker J.O., Salva A., et al. Screening for undernutrition in geriatric practice: developing the short-form mini-nutritional assessment (MNA-SF). J Gerontol A Biol Sci Med Sci 2001, 56:M366.
21. Wilson M.M., Thomas D.R., Rubenstein L.Z., et al. Appetite assessment: simple appetite questionnaire predicts weight loss in community-dwelling adults and nursing home residents. Am J Clin Nutr 2005, 82:1074.
22. Morley J.E. Anorexia, body composition, and ageing. Curr Opin Clin Nutr Metab Care 2001, 4:9.
23. Milne A.C., Potter J., Vivanti A., et al. Protein and energy supplementation in elderly people at risk from malnutrition. Cochrane Database Syst Rev 2009, 2. CD003288.
24. Walrand S., Boirie Y. Optimizing protein intake in aging. Curr Opin Clin Nutr Metab Care 2005, 8:89.
25. Rand W.M., Pellett P.L., Young V.R. Meta-analysis of nitrogen balance studies for estimating protein requirements in healthy adults. Am J Clin Nutr 2003, 77:109.
26. Campbell W.W., Evans W.J. Protein requirements of elderly people. Eur J Clin Nutr 1996, 50(Suppl 1):S180.
27. Gaillard C., Alix E., Boirie Y., et al. Are elderly hospitalized patients getting enough protein?. J Am Geriatr Soc 2008, 56:1045.
28. Houston D.K., Nicklas B.J., Ding J., et al. Dietary protein intake is associated with lean mass change in older, community-dwelling adults: the Health, Aging, and Body Composition (Health ABC) Study. Am J Clin Nutr 2008, 87:150.
29. Short K.R., Nair K.S. The effect of age on protein metabolism. Curr Opin Clin Nutr Metab Care 2000, 3:39.
30. Boirie Y., Gachon P., Beaufrere B. Splanchnic and whole-body leucine kinetics in young and elderly men. Am J Clin Nutr 1997, 65:489.
31. Volpi E., Mittendorfer B., Wolf S.E., et al. Oral amino acids stimulate muscle protein anabolism in the elderly despite higher first-pass splanchnic extraction. Am J Physiol 1999, 277:E513.
32. Volpi E., Mittendorfer B., Rasmussen B.B., et al. The response of muscle protein anabolism to combined hyperaminoacidemia and glucose-induced hyperinsulinemia is impaired in the elderly. J Clin Endocrinol Metab 2000, 85:4481.
33. Pannemans D.L., Wagenmakers A.J., Westerterp K.R., et al. Effect of protein source and quantity on protein metabolism in elderly women. Am J Clin Nutr 1998, 68:1228.
34. Boirie Y., Dangin M., Gachon P., et al. Slow and fast dietary proteins differently modulate postprandial protein accretion. Proc Natl Acad Sci U S A 1997, 94:14930.
35. Paddon-Jones D., Sheffield-Moore M., Katsanos C.S., et al. Differential stimulation of muscle protein synthesis in elderly humans following isocaloric ingestion of amino acids or whey protein. Exp Gerontol 2006, 41:215.
36. Volpi E., Kobayashi H., Sheffield-Moore M., et al. Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults. Am J Clin Nutr 2003, 78:250.
37. Hayes A., Cribb P.J. Effect of whey protein isolate on strength, body composition and muscle hypertrophy during resistance training. Curr Opin Clin Nutr Metab Care 2008, 11:40.
38. Arnal M.A., Mosoni L., Boirie Y., et al. Protein pulse feeding improves protein retention in elderly women. Am J Clin Nutr 1999, 69:1202.
39. Wolfe R.R. Regulation of muscle protein by amino acids. J Nutr 2002, 132:3219S.
40. Tipton K.D., Rasmussen B.B., Miller S.L., et al. Timing of amino acid-carbohydrate ingestion alters anabolic response of muscle to resistance exercise. Am J Physiol Endocrinol Metab 2001, 281:E197.
41. Braddy K.K., Imam S.N., Palla K.R., et al. Vitamin D deficiency/insufficiency practice patterns in a veterans health administration long-term care population: a retrospective analysis. J Am Med Dir Assoc 2009, 10:653.
42. Holick M.F. The vitamin D deficiency pandemic and consequences for nonskeletal health: mechanisms of action. Mol Aspects Med 2008, 29:361.
43. Bischoff H.A., Stahelin H.B., Dick W., et al. Effects of vitamin D and calcium supplementation on falls: a randomized controlled trial. J Bone Miner Res 2003, 18:343.
44. Moreira-Pfrimer L.D., Pedrosa M.A., Teixeira L., et al. Treatment of vitamin D deficiency increases lower limb muscle strength in institutionalized older people independently of regular physical activity: a randomized double-blind controlled trial. Ann Nutr Metab 2009, 54:291.
45. Pfeifer M., Begerow B., Minne H.W., et al. Effects of a long-term vitamin D and calcium supplementation on falls and parameters of muscle function in community-dwelling older individuals. Osteoporos Int 2009, 20:315.
46. Bischoff-Ferrari H.A., Dawson-Hughes B., Staehelin H.B., et al. Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials. BMJ 2009, 339:b3692.
47. Rolland Y., Czerwinski S., Abellan Van Kan G., et al. Sarcopenia: its assessment, etiology, pathogenesis, consequences and future perspectives. J Nutr Health Aging 2008, 12:433.
48. Janssen I., Heymsfield S.B., Wang Z.M., et al. Skeletal muscle mass and distribution in 468 men and women aged 18-88 yr. J Appl Physiol 2000, 89:81.
49. Kortebein P., Ferrando A., Lombeida J., et al. Effect of 10 days of bed rest on skeletal muscle in healthy older adults. JAMA 2007, 297:1772.
50. Glover E.I., Phillips S.M., Oates B.R., et al. Immobilization induces anabolic resistance in human myofibrillar protein synthesis with low and high dose amino acid infusion. J Physiol 2008, 586:6049.
51. Marzetti E., Leeuwenburgh C. Skeletal muscle apoptosis, sarcopenia and frailty at old age. Exp Gerontol 2006, 41:1234.
52. Fiatarone M.A., O'Neill E.F., Ryan N.D., et al. Exercise training and nutritional supplementation for physical frailty in very elderly people. N Engl J Med 1994, 330:1769.
53. Hagerman F.C., Walsh S.J., Staron R.S., et al. Effects of high-intensity resistance training on untrained older men. I. Strength, cardiovascular, and metabolic responses. J Gerontol A Biol Sci Med Sci 2000, 55:B336.
54. Ivey F.M., Roth S.M., Ferrell R.E., et al. Effects of age, gender, and myostatin genotype on the hypertrophic response to heavy resistance strength training. J Gerontol A Biol Sci Med Sci 2000, 55:M641.
55. Jozsi A.C., Campbell W.W., Joseph L., et al. Changes in power with resistance training in older and younger men and women. J Gerontol A Biol Sci Med Sci 1999, 54:M591.
56. Yarasheski K.E., Pak-Loduca J., Hasten D.L., et al. Resistance exercise training increases mixed muscle protein synthesis rate in frail women and men >/=76 yr old. Am J Physiol 1999, 277:E118.
57. Hasten D.L., Pak-Loduca J., Obert K.A., et al. Resistance exercise acutely increases MHC and mixed muscle protein synthesis rates in 78-84 and 23-32 yr olds. Am J Physiol Endocrinol Metab 2000, 278:E620.
58. Yarasheski K.E., Zachwieja J.J., Bier D.M. Acute effects of resistance exercise on muscle protein synthesis rate in young and elderly men and women. Am J Physiol 1993, 265:E210.
59. Edstrom E., Altun M., Bergman E., et al. Factors contributing to neuromuscular impairment and sarcopenia during aging. Physiol Behav 2007, 92:129.
60. Clark B.C., Manini T.M. Sarcopenia =/= dynapenia. J Gerontol A Biol Sci Med Sci 2008, 63:829.
61. Williams M.A., Haskell W.L., Ades P.A., et al. Resistance exercise in individuals with and without cardiovascular disease: 2007 update: a scientific statement from the American Heart Association Council on Clinical Cardiology and Council on Nutrition, Physical Activity, and Metabolism. Circulation 2007, 116:572.
62. Medicine ACoS ACSM's guidelines for exercise testing and prescription 2006, Medicine ACoS, Philadelphia.
63. American Geriatrics Society Panel on Exercise and Osteoarthritis Exercise prescription for older adults with osteoarthritis pain: consensus practice recommendations. A supplement to the AGS Clinical Practice Guidelines on the management of chronic pain in older adults. J Am Geriatr Soc 2001, 49:808.
64. Sheffield-Moore M., Yeckel C.W., Volpi E., et al. Postexercise protein metabolism in older and younger men following moderate-intensity aerobic exercise. Am J Physiol Endocrinol Metab 2004, 287:E513.
65. Coggan A.R., Spina R.J., King D.S., et al. Skeletal muscle adaptations to endurance training in 60- to 70-yr-old men and women. J Appl Physiol 1992, 72:1780.
66. Ottenbacher K.J., Ottenbacher M.E., Ottenbacher A.J., et al. Androgen treatment and muscle strength in elderly men: a meta-analysis. J Am Geriatr Soc 2006, 54:1666.
67. Rolland Y.M., Perry H.M., Patrick P., et al. Loss of appendicular muscle mass and loss of muscle strength in young postmenopausal women. J Gerontol A Biol Sci Med Sci 2007, 62:330.
68. Taaffe D.R., Newman A.B., Haggerty C.L., et al. Estrogen replacement, muscle composition, and physical function: the Health ABC Study. Med Sci Sports Exerc 2005, 37:1741.
69. Brown M., Birge S.J., Kohrt W.M. Hormone replacement therapy does not augment gains in muscle strength or fat-free mass in response to weight-bearing exercise. J Gerontol A Biol Sci Med Sci 1997, 52:B166.
70. Clavel S., Coldefy A.S., Kurkdjian E., et al. Atrophy-related ubiquitin ligases, atrogin-1 and MuRF1 are up-regulated in aged rat tibialis anterior muscle. Mech Ageing Dev 2006, 127:794.
71. Rasmussen B.B., Phillips S.M. Contractile and nutritional regulation of human muscle growth. Exerc Sport Sci Rev 2003, 31:127.
72. Emmelot-Vonk M.H., Verhaar H.J., Nakhai Pour H.R., et al. Effect of testosterone supplementation on functional mobility, cognition, and other parameters in older men: a randomized controlled trial. JAMA 2008, 299:39.
73. Katznelson L., Finkelstein J.S., Schoenfeld D.A., et al. Increase in bone density and lean body mass during testosterone administration in men with acquired hypogonadism. J Clin Endocrinol Metab 1996, 81:4358.
74. Ly L.P., Jimenez M., Zhuang T.N., et al. A double-blind, placebo-controlled, randomized clinical trial of transdermal dihydrotestosterone gel on muscular strength, mobility, and quality of life in older men with partial androgen deficiency. J Clin Endocrinol Metab 2001, 86:4078.
75. Morley J.E., Perry H.M., Kaiser F.E., et al. Effects of testosterone replacement therapy in old hypogonadal males: a preliminary study. J Am Geriatr Soc 1993, 41:149.
76. Sih R., Morley J.E., Kaiser F.E., et al. Testosterone replacement in older hypogonadal men: a 12-month randomized controlled trial. J Clin Endocrinol Metab 1997, 82:1661.
77. Tenover J.S. Effects of testosterone supplementation in the aging male. J Clin Endocrinol Metab 1992, 75:1092.
78. Srinivas-Shankar U., Roberts S.A., Connolly M.J., et al. Effects of testosterone on muscle strength, physical function, body composition, and quality of life in intermediate-frail and frail elderly men: a randomized, double-blind, placebo-controlled study. J Clin Endocrinol Metab 2010, 95:639.
79. Chapman I.M., Visvanathan R., Hammond A.J., et al. Effect of testosterone and a nutritional supplement, alone and in combination, on hospital admissions in undernourished older men and women. Am J Clin Nutr 2009, 89:880.
80. LeBrasseur N.K., Lajevardi N., Miciek R., et al. Effects of testosterone therapy on muscle performance and physical function in older men with mobility limitations (The TOM Trial): design and methods. Contemp Clin Trials 2009, 30:133.
81. Basaria S., Coviello A.D., Travison T.G., et al. Adverse events associated with testosterone administration. N Engl J Med 2010, 363:109.
82. Li J.J., Sutton J.C., Nirschl A., et al. Discovery of potent and muscle selective androgen receptor modulators through scaffold modifications. J Med Chem 2007, 50:3015.
83. Hennessey J.V., Chromiak J.A., DellaVentura S., et al. Growth hormone administration and exercise effects on muscle fiber type and diameter in moderately frail older people. J Am Geriatr Soc 2001, 49:852.
84. Lange K.H., Andersen J.L., Beyer N., et al. GH administration changes myosin heavy chain isoforms in skeletal muscle but does not augment muscle strength or hypertrophy, either alone or combined with resistance exercise training in healthy elderly men. J Clin Endocrinol Metab 2002, 87:513.
85. Taaffe D.R., Pruitt L., Reim J., et al. Effect of recombinant human growth hormone on the muscle strength response to resistance exercise in elderly men. J Clin Endocrinol Metab 1994, 79:1361.
86. Yarasheski K.E., Zachwieja J.J., Campbell J.A., et al. Effect of growth hormone and resistance exercise on muscle growth and strength in older men. Am J Physiol 1995, 268:E268.
87. Sattler F.R., Castaneda-Sceppa C., Binder E.F., et al. Testosterone and growth hormone improve body composition and muscle performance in older men. J Clin Endocrinol Metab 1991, 94:2009.
88. Blackman M.R., Sorkin J.D., Munzer T., et al. Growth hormone and sex steroid administration in healthy aged women and men: a randomized controlled trial. JAMA 2002, 288:2282.
89. Brill K.T., Weltman A.L., Gentili A., et al. Single and combined effects of growth hormone and testosterone administration on measures of body composition, physical performance, mood, sexual function, bone turnover, and muscle gene expression in healthy older men. J Clin Endocrinol Metab 2002, 87:5649.
90. Molfino A., Laviano A., Rossi Fanelli F. Contribution of anorexia to tissue wasting in cachexia. Curr Opin Support Palliat Care 2010, 4:249.
91. Nass R., Pezzoli S.S., Oliveri M.C., et al. Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial. Ann Intern Med 2008, 149:601.
92. Onder G., Della Vedova C., Landi F. Validated treatments and therapeutics prospectives regarding pharmacological products for sarcopenia. J Nutr Health Aging 2009, 13:746.
93. Hanggi W., Lippuner K., Jaeger P., et al. Differential impact of conventional oral or transdermal hormone replacement therapy or tibolone on body composition in postmenopausal women. Clin Endocrinol (Oxf) 1998, 48:691.
94. Jacobsen D.E., Samson M.M., Kezic S., et al. Postmenopausal HRT and tibolone in relation to muscle strength and body composition. Maturitas 2007, 58:7.
95. Artaza J.N., Bhasin S., Magee T.R., et al. Myostatin inhibits myogenesis and promotes adipogenesis in C3H 10T(1/2) mesenchymal multipotent cells. Endocrinology 2005, 146:3547.
96. Tsuchida K. Targeting myostatin for therapies against muscle-wasting disorders. Curr Opin Drug Discov Devel 2008, 11:487.
97. Kung T., Springer J., Doehner W., et al. Novel treatment approaches to cachexia and sarcopenia: highlights from the 5th Cachexia Conference. Expert Opin Investig Drugs 2010, 19:579.
98. Savo A., Maiorano P.M., Onder G., et al. Pharmacoepidemiology and disability in older adults: can medications slow the age-related decline in physical function?. Expert Opin Pharmacother 2004, 5:407.
99. Sumukadas D., Witham M.D., Struthers A.D., et al. Ace inhibitors as a therapy for sarcopenia-evidence and possible mechanisms. J Nutr Health Aging 2008, 12:480.
100. Di Bari M., van de Poll-Franse L.V., Onder G., et al. Antihypertensive medications and differences in muscle mass in older persons: the Health, Aging and Body Composition Study. J Am Geriatr Soc 2004, 52:961.
101. Sumukadas D., Witham M.D., Struthers A.D., et al. Effect of perindopril on physical function in elderly people with functional impairment: a randomized controlled trial. CMAJ 2007, 177:867.
102. Brose A., Parise G., Tarnopolsky M.A. Creatine supplementation enhances isometric strength and body composition improvements following strength exercise training in older adults. J Gerontol A Biol Sci Med Sci 2003, 58:11.
103. Chrusch M.J., Chilibeck P.D., Chad K.E., et al. Creatine supplementation combined with resistance training in older men. Med Sci Sports Exerc 2001, 33:2111.
104. Jakobi J.M., Rice C.L., Curtin S.V., et al. Neuromuscular properties and fatigue in older men following acute creatine supplementation. Eur J Appl Physiol 2001, 84:321.
105. Rawson E.S., Wehnert M.L., Clarkson P.M. Effects of 30 days of creatine ingestion in older men. Eur J Appl Physiol Occup Physiol 1999, 80:139.
106. Pahor M., Blair S.N., Espeland M., et al. Effects of a physical activity intervention on measures of physical performance: Results of the lifestyle interventions and independence for Elders Pilot (LIFE-P) study. J Gerontol A Biol Sci Med Sci 2006, 61:1157.
107. Gillette-Guyonnet S., Andrieu S., Dantoine T., et al. Commentary on "A roadmap for the prevention of dementia II. Leon Thal Symposium 2008." The Multidomain Alzheimer Preventive Trial (MAPT): a new approach to the prevention of Alzheimer's disease. Alzheimers Dement 2009, 5:114.