Discovery of new antimalarial chemotypes through chemical methodology and library development

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 17, 2011, Pages 6775-6780

  Brown, Lauren E ^a   Cheng, Ken Chih Chien ^b   Wei, Wan Guo ^a   Yuan, Pingwei ^a   Dai, Peng ^a   Trilles, Richard ^a   Ni, Feng ^a   Yuan, Jing ^c   MacArthur, Ryan ^b   Guha, Rajarshi ^b   Johnson, Ronald L ^b   Su, Xin Zhuan ^c   Dominguez, Melissa M ^a   Snyder, John K ^a   Beeler, Aaron B ^a   Schaus, Scott E ^a   Inglese, James ^b   Porco Jr , John A ^a  

^a Boston University   (United States)

^b NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Chemical biology; Organocatalytic; Polycyclic ketal

Indexed keywords

ACETAL; ANTIMALARIAL AGENT; GUANIDINE DERIVATIVE; INDOLE ALKALOID; NEW DRUG; POLYCYCLIC AROMATIC COMPOUND; PYRIMIDINONE DERIVATIVE;

ARTICLE; CELL VIABILITY; CHEMICAL ANALYSIS; CONTROLLED STUDY; DRUG DESIGN; DRUG RESEARCH; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC 50; METHODOLOGY; MICROBIAL VIABILITY; MOLECULAR LIBRARY; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANTIMALARIALS; HUMANS; MALARIA, FALCIPARUM; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP;

PLASMODIUM FALCIPARUM;

EID: 79955560248     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1017666108     Document Type: Article

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