Do calcium plus vitamin D supplements increase cardiovascular risk? Insufficient evidence is available to support or refute the association

BMJ

Volumn 342, Issue 7804, 2011, Pages

  Abrahamsen, Bo ^a   Sahota, Opinder ^b  

^a GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^b QUEEN S MEDICAL CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; VITAMIN D DERIVATIVE; BONE DENSITY CONSERVATION AGENT; VITAMIN D;

CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CONFIDENCE INTERVAL; DRUG EFFICACY; DRUG SAFETY; DRUG USE; EDITORIAL; HEART INFARCTION; HUMAN; MORTALITY; OSTEOPOROSIS; PRIORITY JOURNAL; SEX DIFFERENCE; STROKE; VITAMIN SUPPLEMENTATION; CALCIUM INTAKE; DIET SUPPLEMENTATION; FEMALE; NOTE; POSTMENOPAUSE OSTEOPOROSIS;

BONE DENSITY CONSERVATION AGENTS; CALCIUM, DIETARY; CARDIOVASCULAR DISEASES; DIETARY SUPPLEMENTS; FEMALE; HUMANS; OSTEOPOROSIS, POSTMENOPAUSAL; VITAMIN D;

EID: 79955548490     PISSN: None     EISSN: 17561833     Source Type: Journal    
DOI: 10.1136/bmj.d2080     Document Type: Editorial

References (8)

1. Bolland MJ, Avenell A, Baron JA, Grey A, MacLennan GS, Gamble GD, et al. Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis. BMJ 2010;341:c3691.
2. Bolland MJ, Grey A, Avenell A, Gamble GD, Reid IR. Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women's Health Initiative limited access dataset and meta-analysis. BMJ 2011;342:d2040.
3. Jackson RD, LaCroix AZ, Gass M, Wallace RB, Robbins J, Lewis CE, et al. Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med 2006;354:669-83. (Pubitemid 43247138)
4. Camm JA. Review of the cardiovascular safety of zoledronic acid and other bisphosphonates for the treatment of osteoporosis. Clin Ther 2010;32:426-36.
5. Christensen S, Mehnert F, Chapurlat RD, Baron JA, Sørensen HT. Oral bisphosphonates and risk of ischemic stroke: a case-control study. Osteoporos Int 2010; online 13 October.
6. Center JR, Bliuc D, Nguyen ND, Nguyen TV, Eisman JA. Osteoporosis medication and reduced mortality risk in elderly women and men. J Clin Endocrinol Metab 2011; online 2 February.
7. Nurmi-Lüthje I, Sund R, Juntunen M, Lüthje P. Post-hip fracture use of prescribed calcium plus vitamin D or vitamin D supplements and anti-osteoporotic drugs are associated with lower mortality. A nationwide study in Finland. J Bone Miner Res 2011; online 23 February.
8. Bolland MJ, Grey AB, Gamble GD, Reid IR. Effect of osteoporosis treatment on mortality: a meta-analysis. J Clin Endocrinol Metab 2010;95:1174-81.