Triggered Mycobacterium tuberculosis heparin-binding hemagglutinin adhesin folding and dimerization

Journal of Bacteriology

Volumn 193, Issue 9, 2011, Pages 2089-2096

  Lomino, Joseph V ^a,b   Tripathy, Ashutosh ^b,c   Redinbo, Matthew R ^a,b,c  

^a University of North Carolina at Chapel Hill   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESIN; HEMAGGLUTININ; HEPARAN SULFATE; HEPARIN BINDING HEMAGGLUTININ ADHESIN; HEPARIN BINDING PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL SURFACE; CIRCULAR DICHROISM; DIMERIZATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN STABILITY; ULTRACENTRIFUGATION;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; CLONING, MOLECULAR; GENE EXPRESSION REGULATION, BACTERIAL; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; MYCOBACTERIUM TUBERCULOSIS; PROTEIN CONFORMATION; PROTEIN FOLDING;

MYCOBACTERIUM TUBERCULOSIS;

EID: 79955547725     PISSN: 00219193     EISSN: 10985530     Source Type: Journal    
DOI: 10.1128/JB.01231-10     Document Type: Article

References (21)

1. Dupres, V., et al. 2005. Nanoscale mapping and functional analysis of individual adhesins on living bacteria. Nat. Methods 2:515-520.
2. Esposito, C., et al. 2010. Dimerisation and structural integrity of heparin binding hemagglutinin A from Mycobacterium tuberculosis: implications for bacterial agglutination. FEBS Lett. 584:1091-1096.
3. Esposito, C., et al. 2008. Evidence for an elongated dimeric structure of heparin-binding hemagglutinin from Mycobacterium tuberculosis. J. Bacteriol. 190:4749-4753.
4. Gruber, M., J. Soding, and A. N. Lupas. 2006. Comparative analysis of coiled-coil prediction methods. J. Struct. Biol. 155:140-145.
5. Guerrero, G. G., A. S. Debrie, and C. Locht. 2010. Boosting with mycobacterial heparin-binding haemagglutinin enhances protection of Mycobacterium bovis BCG-vaccinated newborn mice against M. tuberculosis. Vaccine 28:4340-4347.
6. Hingley-Wilson, S. M., V. K. Sambandamurthy, and W. R. Jacobs, Jr. 2003. Survival perspectives from the world's most successful pathogen, Mycobacterium tuberculosis. Nat. Immunol. 4:949-955.
7. Hougardy, J. M., et al. 2007. Heparin-binding-hemagglutinin-induced IFNgamma release as a diagnostic tool for latent tuberculosis. PLoS One 2:e926.
8. Kammerer, R. A., et al. 1998. An autonomous folding unit mediates the assembly of two-stranded coiled coils. Proc. Natl. Acad. Sci. U. S. A. 95: 13419-13424.
9. Locht, C., J. M. Hougardy, C. Rouanet, S. Place, and F. Mascart. 2006. Heparin-binding hemagglutinin, from an extrapulmonary dissemination factor to a powerful diagnostic and protective antigen against tuberculosis. Tuberculosis (Edinb.). 86:303-309.
10. Lupas, A. 1996. Coiled coils: new structures and new functions. Trends Biochem. Sci. 21:375-382.
11. Menozzi, F. D., R. Bischoff, E. Fort, M. J. Brennan, and C. Locht. 1998. Molecular characterization of the mycobacterial heparin-binding hemagglutinin, a mycobacterial adhesin. Proc. Natl. Acad. Sci. U. S. A. 95:12625-12630.
12. Menozzi, F. D., et al. 2006. Mycobacterium tuberculosis heparin-binding haemagglutinin adhesin (HBHA) triggers receptor-mediated transcytosis without altering the integrity of tight junctions. Microbes Infect. 8:1-9.
13. Menozzi, F. D., et al. 1996. Identification of a heparin-binding hemagglutinin present in mycobacteria. J. Exp. Med. 184:993-1001.
14. Mooij, W. T., E. Mitsiki, and A. Perrakis. 2009. ProteinCCD: enabling the design of protein truncation constructs for expression and crystallization experiments. Nucleic Acids Res. 37:W402-W405.
15. Pethe, K., et al. 2001. The heparin-binding haemagglutinin of M. tuberculosis is required for extrapulmonary dissemination. Nature 412:190-194.
16. Pethe, K., et al. 2000. Characterization of the heparin-binding site of the mycobacterial heparin-binding hemagglutinin adhesin. J. Biol. Chem. 275: 14273-14280.
17. Scholtz, J. M., H. Qian, E. J. York, J. M. Stewart, and R. L. Baldwin. 1991. Parameters of helix-coil transition theory for alanine-based peptides of varying chain lengths in water. Biopolymers 31:1463-1470.
18. Schuck, P. 2003. On the analysis of protein self-association by sedimentation velocity analytical ultracentrifugation. Anal. Biochem. 320:104-124.
19. Schuck, P. 2000. Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and Lamm equation modeling. Biophys. J. 78:1606-1619.
20. Stols, L., et al. 2002. A new vector for high-throughput, ligation-independent cloning encoding a tobacco etch virus protease cleavage site. Protein Expr. Purif. 25:8-15.
21. Varki, A., C. R. J. Esko, F. Hudson, G. Hart, and J. Marth. 1999. Essentials of glycobiology, 1st ed., vol. 1. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.