Screening for compounds with aromatase inhibiting activities from Atractylodes macrocephala koidz

Molecules

Volumn 16, Issue 4, 2011, Pages 3146-3151

  Jiang, Hai ^a   Shi, Jing ^b   Li, Yuanyuan ^b  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Aromatase; Atractylenolide; Atractylodes macrocephala

Indexed keywords

AROMATASE INHIBITOR; PLANT EXTRACT;

ARTICLE; ATRACTYLODES; CHEMISTRY; DRUG SCREENING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; INFRARED SPECTROPHOTOMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

AROMATASE INHIBITORS; ATRACTYLODES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG EVALUATION, PRECLINICAL; MAGNETIC RESONANCE SPECTROSCOPY; PLANT EXTRACTS; SPECTROPHOTOMETRY, INFRARED;

EID: 79955543582     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules16043146     Document Type: Article

References (15)

1. Brueggemeier, R.W.; Richards, J.A.; Joomprabutra, S.; Bhat, A.S.; Whetstone, J.L.J. Molecular pharmacology of aromatase and its regulation by endogenous and exogenous agents. J. Steroid Biochem. Mol. Biol. 2001, 79, 75-84. (Pubitemid 34158781)
2. Leonetti, F.; Favia, A.; Rao, A.; Aliano, R.; Paluszcak, A.; Hartmann, R.W.; Carotti, A. Design, synthesis, and 3D QSAR of novel potent and selective aromatase inhibitors. J. Med. Chem. 2004, 47, 6792-6803. (Pubitemid 40053767)
3. Lonard, D.M.; Smith, C.L. Molecular perspectives on selective estrogen receptor modulators (SERMs): Progress in understanding their tissue-specific agonist and antagonist actions. Steroids 2002, 67, 15-24. (Pubitemid 33112000)
4. Park, W.C.; Jordan, V.C. Selective estrogen receptor modulators (SERMS) and their roles in breast cancer prevention. Trends Mol. Med. 2002, 8, 82-88. (Pubitemid 34094444)
5. Ghosh, D.; Griswold, J.; Erman, M.; Pangborn, W. Structural basis for androgen specificity and oestrogen synthesis in human aromatase. Nature 2009, 457, 219-223.
6. Santen, R.J.; Samojlik, E.; Lipton, A.; Harvey, H.; Ruby, E.B.; Wells, S.A.; Kendall, J. Kinetic, hormonal and clinical studies with aminoglutethimide in breast-cancer. Cancer 1977, 39, 2948-2958. (Pubitemid 8130408)
7. O'Reilly, J.M.; Brueggemeier, R.W. 7α-Arylaliphatic androsta-1, 4-diene-3, 17-diones as enzymeactivated irreversible inhibitors of aromatase. J. Steroid Biochem. Mol. Biol. 1996, 159, 93-102.
8. Chen, Z.L. The acetylenes from Atractylodes macrocephala. Planta Med. 1987, 53, 493-494.
9. Endo, K.; Taguchi, T.; Taguchi, F.; Hikino, H.; Yamahara, J.; Fujimura, H. Anti-inflammatory principles of Atractylodes rhizomes. Chem. Pharm. Bull. 1979, 27, 2954-2958.
10. Huang, B.S.; Sun, J.S.; Chen, Z.L. Isolation and identification of atractylenolide VI from Atractylodes macrocephala Koidz. Acta Bot. Sin. 1992, 34, 614-617.
11. Wang, H.X.; Liu, C.M.; Liu, Q.; Gao, K. Three types of sesquiterpenes from rhizomes of Atractylodes lancea. Phytochemistry 2008, 69, 2088-2094.
12. Li, C.Q.; He, L.C.; Dong, H.Y.; Jin, J.Q. Screening for the anti-inflammatory activity of fractions and compounds from Atractylodes macrocephala koidz. J. Ethnopharmacol. 2007, 114, 212-217.
13. Dong, H.Y.; He, L.C.; Huang, M.; Dong, Y.L. Anti-inflammatory components isolated from Atractylodes macrocephala Koidz. Nat. Prod. Res. 2008, 22, 1418-1427.
14. Peng, W.; Han, T.; Wang, Y.; Xin, W.B.; Zheng, C.J.; Qin, L.P. Chemical constituents of the aerial part of Atractylodes macrocephala. Chem. Nat. Compd. 2011, 46, 959-960.
15. Endringer, D.C.; Guimaraes, K.G.; Kondratyuk, T.P.; Pezzuto, J.M.; Braga, F.C. Selective inhibition of aromatase by a dihydroisocoumarin from Xyris pterygoblephara. J. Nat. Prod. 2008, 71, 1082-1084. (Pubitemid 352008913)