The 1000 genomes project: Deep genomic sequencing waiting for deep psychiatric phenotyping

Journal of Psychiatry and Neuroscience

Volumn 36, Issue 3, 2011, Pages 147-149

  Joober, Ridha ^a  

^a DOUGLAS MENTAL HEALTH UNIVERSITY INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

COPY NUMBER VARIATION; EDITORIAL; GENE MAPPING; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOME; GENOTYPE; HUMAN; MENTAL DISEASE; PHENOTYPE; SEQUENCE ANALYSIS;

EID: 79955537084     PISSN: 11804882     EISSN: 14882434     Source Type: Journal    
DOI: 10.1503/jpn.110026     Document Type: Editorial

References (25)

1. Durbin RM, Abecasis GR, Altshuler DL, et al. A map of human genome variation from population-scale sequencing. Nature 2010;467:1061-73.
2. Gershon ES, Alliey-Rodriguez N, Liu C. After GWAS: searching for genetic risk for schizophrenia and bipolar disorder. Am J Psychiatry 2011;168:253-6.
3. Vineis P, Pearce N. Missing heritability in genome-wide association study research. Nat Rev Genet 2010;11:589.
4. Lindsay EA, Morris MA, Gos A, et al. Schizophrenia and chromosomal deletions within 22q11.2. Am J Hum Genet 1995;56:1502-3.
5. Green T, Gothelf D, Glaser B, et al. Psychiatric disorders and intellectual functioning throughout development in velocardiofacial (22q11.2 deletion) syndrome. J Am Acad Child Adolesc Psychiatry 2009;48:1060-8.
6. Jolin EM, Weller RA, Weller EB. Occurrence of affective disorders compared to other psychiatric disorders in children and adolescents with 22q11.2 deletion syndrome. J Affect Disord 2011 Jan. 5. [Epub ahead of print]
7. Niklasson L, Rasmussen P, Oskarsdottir S, et al. Autism, ADHD, mental retardation and behavior problems in 100 individuals with 22q11 deletion syndrome. Res Dev Disabil 2009;30:763-73.
8. Jacobson C, Shearer J, Habel A, et al. Core neuropsychological characteristics of children and adolescents with 22q11.2 deletion. J Intellect Disabil Res 2010;54:701-13.
9. Simon TJ. A new account of the neurocognitive foundations of impairments in space, time and number processing in children with chromosome 22q11.2 deletion syndrome. Dev Disabil Res Rev 2008;14:52-8.
10. Mouaffak F, Kebir O, Chayet M et al. Association of Disrupted in Schizophrenia 1 (Drosoph Inf ServC1) missense variants with ultra-resistant schizophrenia. Pharmacogenomics J 2010 June 8. [Epub ahead of print]
11. Crepel A, Breckpot J, Fryns JP, et al. Drosoph Inf ServC1 duplication in two brothers with autism and mild mental retardation. Clin Genet 2010;77:389-94.
12. Hodgkinson CA, Goldman D, Jaeger J, et al. Disrupted in schizophrenia 1 (Drosoph Inf ServC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder. Am J Hum Genet 2004;75:862-72.
13. Harris SE, Hennah W, Thomson PA, et al. Variation in Drosoph Inf ServC1 is associated with anxiety, depression and emotional stability in elderly women. Mol Psychiatry 2010;15:232-4.
14. Vassos E, Collier DA, Holden S, et al. Penetrance for copy number variants associated with schizophrenia. Hum Mol Genet 2010;19: 3477-81.
15. Sisodiya SM, Mefford HC. Genetic contribution to common epilepsies. Curr Opin Neurol 2011;24:140-5.
16. Endris V, Hackmann K, Neuhann TM, et al. Homozygous loss of CHRNA7 on chromosome 15q13.3 causes severe encephalopathy with seizures and hypotonia. Am J Med Genet A 2010;152A:2908-11.
17. Coon H, Villalobos ME, Robison RJ, et al. Genome-wide linkage using the Social Responsiveness Scale in Utah autism pedigrees. Mol Autism 2010;1:8.
18. Durand CM, Betancur C, Boeckers TM, et al. Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders. Nat Genet 2007;39:25-7.
19. Gauthier J, Champagne N, Lafreniere RG, et al. De novo mutations in the gene encoding the synaptic scaffolding protein SHANK3 in patients ascertained for schizophrenia. Proc Natl Acad Sci U S A 2010; 107:7863-8.
20. McMullan DJ, Bonin M, Hehir-Kwa JY, et al. Molecular karyotyping of patients with unexplained mental retardation by SNP arrays: a multicenter study. Hum Mutat 2009;30:1082-92.
21. Stefansson H, Rujescu D, Cichon S, et al. Large recurrent micro - deletions associated with schizophrenia. Nature 2008;455:232-6.
22. Koenen KC, Moffitt TE, Roberts AL, et al. Childhood IQ and adult mental disorders: a test of the cognitive reserve hypothesis. Am J Psychiatry 2009;166:50-7.
23. Grozeva D, Kirov G, Ivanov D, et al. Rare copy number variants: a point of rarity in genetic risk for bipolar disorder and schizophrenia. Arch Gen Psychiatry 2010;67:318-27.
24. Fangerau H, Ohlraun S, Granath RO, et al. Computer-assisted phenotype characterization for genetic research in psychiatry. Hum Hered 2004;58:122-30.
25. Calkins ME, Dobie DJ, Cadenhead KS, et al. The Consortium on the Genetics of Endophenotypes in Schizophrenia: model recruitment, assessment, and endophenotyping methods for a multisite collaboration. Schizophr Bull 2007;33:33-48.