Controlled release of bis(phosphonate) pharmaceuticals from cationic biodegradable polymeric matrices

Industrial and Engineering Chemistry Research

Volumn 50, Issue 9, 2011, Pages 5873-5876

  Demadis, Konstantinos D ^a   Paspalaki, Maria ^a   Theodorou, Joanna ^a  

^a UNIVERSITY OF CRETE   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE INGREDIENTS; AQUEOUS SOLUTIONS; CONTROLLED RELEASE; ETIDRONATE; OSTEOPOROTIC; PHOSPHONATES; PHOSPHONIC; POLYETHYLENEIMINE; POLYMERIC MATRICES; VARIOUS PH;

STARCH;

BIODEGRADABLE POLYMERS;

EID: 79955532596     PISSN: 08885885     EISSN: 15205045     Source Type: Journal    
DOI: 10.1021/ie102546g     Document Type: Article

References (29)

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17. -1. These bands are also found in the CATIN-etidronate composites. The bands assigned to the phosponate moieties appear shifted compared to those of an authentic sample of etidronic acid, suggesting that etidronic acid is in a deprotonated form in the composites.
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23. Preparation of polymer-etidronate tablets. The exact amounts of starch and polymer-etidronate composites used to prepare the tablets are given in Table S-2 in the Supporting Information. Here we will provide details for the preparation of CATIN-1-etidronate-containing tablet. An amount of 1.6 g of starch (Aldrich Chemical Co.) was mixed with 0.0167 g of the CATIN-1-etidronate composite. The mixture was ground vigorously in a mortar-and-pestle until it became a free-flowing powder. This powder was then transferred in a stainless steel press, and a force of 10 N was applied. The outcome was a nearly perfect round disk of diameter 1.5 cm and thickness 0.5 cm. This tablet contains 1.03% composite. On the basis of the measured % P of 9.34% (see Table S-1 in SI), the actual amount of etidronic acid in the tablet was found to be 16.7 mg, corresponding to ∼ 0.15% of the total tablet weight. Tablets prepared in this fashion were used for the controlled release experiments.
24. Protocol for the controlled release experiments. The controlled release experiments were carried out at pH 3 and ionic strength 0.1 M (NaCl), in order to mimic the conditions present in the stomach during digestion. (19) A 1 L volume of an aqueous solution containing 0.1 M NaCl at pH ∼3 was placed in a 1 L Erlenmeyer flask. Using long stainless steel tongues, the tablet (prepared as described above) was carefully placed at the bottom of the flask, without any stirring at all. This was t = 0 for the release experiment. Fixed aliquots (10 mL) were drawn from the surface of the flask every hour, and they were analyzed by the procedure described in ref 22.
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