Synergistic effect between erlotinib and MEK inhibitors in KRAS wild-type human pancreatic cancer cells

Clinical Cancer Research

Volumn 17, Issue 9, 2011, Pages 2744-2756

  Diep, Caroline H ^a   Munoz, Ruben M ^a   Choudhary, Ashish ^a   Von Hoff, Daniel D ^a   Han, Haiyong ^a  

^a TRANSLATIONAL GENOMICS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; BONE MORPHOGENETIC PROTEIN RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; FLT3 LIGAND; GEMCITABINE; K RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; RDEA 119; SELUMETINIB; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CANCER SURVIVAL; CELL DEATH; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; DRUG SENSITIZATION; DRUG TOLERABILITY; ENZYME INHIBITION; GENE IDENTIFICATION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; SIDE EFFECT; SIGNAL TRANSDUCTION; WEIGHT REDUCTION; WESTERN BLOTTING;

ANIMALS; CARCINOMA, PANCREATIC DUCTAL; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SYNERGISM; FEMALE; HUMANS; MAP KINASE KINASE KINASES; MICE; MICE, INBRED ICR; MICE, SCID; MICE, TRANSGENIC; MUTATION; PANCREATIC NEOPLASMS; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS; QUINAZOLINES; RAS PROTEINS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 79955505489     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-10-2214     Document Type: Article

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