Mesenchymal stem cells expressing GD2 and CD271 correlate with breast cancer-initiating cells in bone marrow

Cancer Biology and Therapy

Volumn 11, Issue 9, 2011, Pages 812-815

  De Giorgi, Ugo ^a,b   Cohen, Evan N ^b   Gao, Hui ^b   Mego, Michal ^b   Lee, Bang Ning ^b   Lodhi, Ashutosh ^b   Cristofanilli, Massimo ^c   Lucci, Anthony ^b   Reuben, James M ^b  

^a DEPARTMENT OF MEDICAL ONCOLOGY   (Italy)

^b UNIVERSITY OF TEXAS   (United States)

^c FOX CHASE CANCER CENTER   (United States)

Author keywords

Bone marrow; Cancer stem cells; Cancer initiating cells; Mesenchymal stem cells; Microenvironment

Indexed keywords

GANGLIOSIDE GD2;

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER CELL; CANCER PATIENT; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN TISSUE; IMMUNOPHENOTYPING; MESENCHYMAL STEM CELL; MONONUCLEAR CELL; PHENOTYPE; PRIMARY TUMOR; PROTEIN EXPRESSION;

ADULT; AGED; ANTIGENS, CD; BONE MARROW CELLS; BREAST NEOPLASMS; FEMALE; GANGLIOSIDES; HUMANS; IMMUNOPHENOTYPING; MESENCHYMAL STEM CELLS; MIDDLE AGED;

EID: 79955495408     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.11.9.15178     Document Type: Article

References (20)

1. Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 2003; 100:3983-8. (Pubitemid 36418143)
2. Charafe-Jauffret E, Ginestier C, Iovino F, Wicinski J, Cervera N, Finetti P, et al. Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature. Cancer Res 2009; 69:1302-13.
3. Balic M, Lin H, Young L, Hawes D, Giuliano A, McNamara G, et al. Most early disseminated cancer cells detected in bone marrow of breast cancer patients have a putative breast cancer stem cell phenotype. Clin Cancer Res 2006; 12:5615-21. (Pubitemid 44629587)
4. Ginestier C, Hur MH, Charafe-Jauffret E, Monville F, Dutcher J, Brown M, et al. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 2007; 1:555-67. (Pubitemid 350056407)
5. Jones E, McGonagle D. Human bone marrow mesenchymal stem cells in vivo. Rheumatology 2008; 47:126-31. (Pubitemid 351168218)
6. Karnoub AE, Dash AB, Vo AP, Sullivan A, Brooks MW, Bell GW, et al. Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 2007; 449:557-63. (Pubitemid 47525152)
7. Zhu W, Xu W, Jiang R, Qian H, Chen M, Hu J, et al. Mesenchymal stem cells derived from bone marrow favor tumor cell growth in vivo. Exp Mol Pathol 2006; 80:267-74.
8. Corcoran KE, Trzaska KA, Fernandes H, Bryan M, Taborga M, Srinivas V, et al. Mesenchymal stem cells in early entry of breast cancer into bone marrow. PLoS ONE 2008; 3:2563.
9. Kaplan RN, Riba RD, Zacharoulis S, Bramley AH, Vincent L, Costa C, et al. VEGFR1-positive haematopoietic bone marrow progenitors initiate the premetastatic niche. Nature 2005; 438:820-7. (Pubitemid 41753060)
10. Martinez C, Hofmann TJ, Marino R, Dominici M, Horwitz EM. Human bone marrow mesenchymal stromal cells express the neural ganglioside GD2: a novel surface marker for the identification of MSCs. Blood 2007; 109:4245-8. (Pubitemid 46743389)
11. Buhring HJ, Battula VL, Treml S, Schewe B, Kanz L, Vogel W. Novel markers for the prospective isolation of human MSC. Ann NY Acad Sci 2007; 1106:262-71. (Pubitemid 47443036)
12. Delorme B, Ringe J, Gallay N, Le Vern Y, Kerboeuf D, Jorgensen C, et al. Specific plasma membrane protein phenotype of culture-amplified and native human bone marrow mesenchymal stem cells. Blood 2008; 111:2631-5.
13. Pantel K, Brakenhoff RH, Brand B. Detection, clinical relevance and specific biological properties of disseminating tumour cells. Nat Rev Cancer 2008; 8:330-40.
14. Direkze NC, Hodivala-Dilke K, Jeffery R, Hunt T, Poulsom R, Oukrif D, et al. Bone marrow contribution to tumor-associated myofibroblasts and fibroblasts. Cancer Res 2004; 64:8492-5. (Pubitemid 39552057)
15. Mishra PJ, Mishra PJ, Glod JW, Banerjee D. Mesenchymal stem cells: flip side of the coin. Cancer Res 2009; 69:1255-8.
16. Khakoo AY, Pati S, Anderson SA, Reid W, Elshal MF, Rovira II, et al. Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma. J Exp Med 2003; 203:1235-47.
17. Lu YR, Yuan Y, Wang XJ, Wei LL, Chen YN, Cong C, et al. The growth inhibitory effect of mesenchymal stem cells on tumor cells in vitro and in vivo. Cancer Biol Ther 2008; 7:245-51. (Pubitemid 351590431)
18. Zhang W. Mesenchymal stem cells in cancer: friends or foes. Cancer Biol Ther 2008; 7:252-4. (Pubitemid 351590432)
19. Bauer KD, de la Torre-Bueno J, Diel IJ, Hawes D, Decker WJ, Priddy C, Bossy B, et al. Reliable and sensitive analysis of occult bone marrow metastases using automated cellular imaging. Clin Cancer Res 2000; 6:3552-9.
20. Liu S, Ginestier C, Ou SJ, Clouthier SG, Patel SH, Monville F, et al. Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks. Cancer Res 2011; 71:614-24.