Fibulin-5: Two for the price of one maintaining pelvic support

Journal of Clinical Investigation

Volumn 121, Issue 5, 2011, Pages 1688-1691

  Northington, Gina M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIBULIN 5; GELATINASE B;

ARTICLE; ENZYME ACTIVITY; HUMAN; NONHUMAN; PELVIC ORGAN PROLAPSE; PELVIS FLOOR; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION;

ANIMALS; DISEASE MODELS, ANIMAL; ELASTIC TISSUE; ELASTIN; EXTRACELLULAR MATRIX PROTEINS; FEMALE; HUMANS; MATRIX METALLOPROTEINASE 9; MICE; MICE, TRANSGENIC; PELVIC FLOOR; PELVIC ORGAN PROLAPSE; PROTEIN STRUCTURE, TERTIARY; TROPOELASTIN; VAGINA;

EID: 79955495220     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI57438     Document Type: Article

References (24)

1. Lawrence JM, Lukacz ES, Nager CW, Hsu JW, Luber KM. Prevalence and co-occurrence of pelvic floor disorders in community-dwelling women. Obstet Gynecol. 2008;111(3):678-685. (Pubitemid 351654073)
2. Lowder JL, Ghetti C, Nikolajski C, Oliphant SS, Zyczynski HM. Body image perceptions in women with pelvic organ prolapse: a qualitative study [published online ahead of print February 1, 2011]. Am J Obstet Gynecol. doi:10.1016/j.ajog.2010.12.024.
3. Word RA, Pathi S, Schaffer JI. Pathophysiology of pelvic organ prolapse. Obstet Gynecol Clin North Am. 2009;36(3):521-539.
4. Lukacz ES, Lawrence JM, Contreras R, Nager CW, Luber KM. Parity, mode of delivery, and pelvic floor disorders. Obstet Gynecol. 2006;107(6):1253-1260. (Pubitemid 44336888)
5. Smith FJ, Holman CD, Moorin RE, Tsokos N. Lifetime risk of undergoing surgery for pelvic organ prolapse. Obstet Gynecol. 2010;116(5):1096-1100.
6. Mattson JA, Kuehl TJ, Yandell PM, Pierce LM, Coates KW. Evaluation of the aged female baboon as a model of pelvic organ prolapse and pelvic reconstructive surgery. Am J Obstet Gynecol. 2005;192(5):1395-1398.
7. Liu X, Zhao Y, Pawlyk B, Damaser M, Li T. Failure of elastic fiber homeostasis leads to pelvic floor disorders. Am J Pathol. 2006;168(2):519-528. (Pubitemid 43271150)
8. Drewes PG, et al. Pelvic organ prolapse in fibulin- 5 knockout mice: pregnancy-induced changes in elastic fiber homeostasis in mouse vagina. Am J Pathol. 2007;170(2):578-589. (Pubitemid 47339395)
9. Rahn DD, et al. Failure of pelvic organ support in mice deficient in fibulin-3. Am J Pathol. 2009;174(1):206-215.
10. Moalli PA, et al. A rat model to study the structural properties of the vagina and its supportive tissues. Am J Obstet Gynecol. 2005;192(1):80-88. (Pubitemid 40164224)
11. Budatha M, et al. Extracellular matrix proteases contribute to progression of pelvic organ prolapse in mice and humans. J Clin Invest. 2011; 121(5):2048-2059.
12. Yanagisawa H, Schluterman MK, Brekken RA. Fibulin-5, an integrin-binding matricellular protein: its function in development and disease. J Cell Commun Signal. 2009;3(3-4):337-347.
13. Carley ME, Schaffer J. Urinary incontinence and pelvic organ prolapse in women with Marfan or Ehlers Danlos syndrome. Am J Obstet Gynecol. 2000;182(5):1021-1023. (Pubitemid 30353268)
14. Jackson SR, Avery NC, Tarlton JF, Eckford SD, Abrams P, Bailey AJ. Changes in metabolism of collagen in genitourinary prolapse. Lancet. 1996;347(9016):1658-1661.
15. Chen BH, Wen Y, Li H, Polan ML. Collagen metabolism and turnover in women with stress urinary incontinence and pelvic prolapse. Int Urogynecol J Pelvic Floor Dysfunct. 2002;13(2):80-87. (Pubitemid 34591422)
16. Moalli PA, Shand SH, Zyczynski HM, Gordy SC, Meyn LA. Remodeling of vaginal connective tissue in patients with prolapse Obstet Gynecol. 2005; 106(5 pt 1):953-963.
17. Stamenkovic I. Extracellular matrix remodelling: the role of matrix metalloproteinases. J Pathol. 2003;200(4):448-464. (Pubitemid 36818245)
18. Mecham RP, Davis EC. Elastic fiber structure and assembly. In: Yurchenko PD, Birk DE, Mecham RP, eds. Extracellular Matrix Assembly and Structure. San Diego, California, USA: Academic Press; 1994:281-314.
19. Wieslander CK, Marinis SI, Drewes PG, Keller PW, Acevedo JF, Word RA. Regulation of elastolytic proteases in the mouse vagina during pregnancy, parturition, and puerperium. Biol Reprod. 2008;78(3):521-528.
20. Liu X, et al. Elastic fiber homeostasis requires lysyl oxidase- like 1 protein. Nat Genet. 2004;36(2):178-182. (Pubitemid 38174378)
21. Kagan HM, Li W. Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell. J Cell Biochem. 2003;88(4):660-672. (Pubitemid 36258816)
22. Argraves WS, Greene LM, Cooley MA, Gallagher WM. Fibulins: physiological and disease perspectives. EMBO Rep. 2003;4(12):1127-1131. (Pubitemid 38088406)
23. Chen HY, Lin WY, Chen YH, Chen WC, Tsai FJ, Tsai CH. Matrix metalloproteinase-9 polymorphism and risk of pelvic organ prolapse in Taiwanese women. Eur J Obstet Gynecol Reprod Biol. 2010;149(2):222-224.
24. McLennan MT, Harris JK, Kariuki B, Meyer S. Family history as a risk factor for pelvic organ prolapse. Int Urogynecol J Pelvic Floor Dysfunct. 2008; 19(8):1063-1069.