Decreased topoisomerase IIα expression and altered histone and regulatory factors of topoisomerase IIα promoter in patients with chronic benzene poisoning

Toxicology Letters

Volumn 203, Issue 2, 2011, Pages 111-117

  Yu, Kang ^a   Shi, Yi Fen ^a   Yang, Kai Yan ^a   Zhuang, Yan ^a   Zhu, Rong He ^a   Xu, Xi ^a   Cai, Guoping ^b  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acetylation; Benzene; Methylation; Topoisomerase II ; Topoisomerase II promoter

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 2; BENZENE; DNA TOPOISOMERASE (ATP HYDROLYSING); HISTONE H3; HISTONE H4; ICBP90 PROTEIN; MESSENGER RNA; NEUROFILAMENT M PROTEIN; NF YA PROTEIN; PREGNANCY ASSOCIATED ALPHA2 GLYCOPROTEIN; PROTEIN C JUN; PROTEIN C MYB; PROTEIN P53; REGULATOR PROTEIN; SP1 PROTEIN; TOPOISOMERASE 2 ALPHA; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BENZENE INTOXICATION; CHROMATIN IMMUNOPRECIPITATION; CLINICAL ARTICLE; DNA CLEAVAGE; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION REGULATION; HISTONE ACETYLATION; HISTONE METHYLATION; HUMAN; HUMAN CELL; IN VIVO STUDY; INTOXICATION; LONG TERM EXPOSURE; MALE; MONONUCLEAR CELL; PRIORITY JOURNAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ACETYLATION; ADULT; ANTIGENS, NEOPLASM; BENZENE; BONE MARROW CELLS; CHROMATIN IMMUNOPRECIPITATION; DNA TOPOISOMERASES, TYPE II; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HISTONES; HUMANS; MALE; METHYLATION; MIDDLE AGED; POISONING; PROMOTER REGIONS, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; YOUNG ADULT;

EID: 79955483280     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2011.02.020     Document Type: Article

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