Glial cells drive preconditioning-induced blood-brain barrier protection

Stroke

Volumn 42, Issue 5, 2011, Pages 1445-1453

  Gesuete, Raffaella ^a   Orsini, Franca ^a   Zanier, Elisa R ^a   Albani, Diego ^a   Deli, Maria A ^b   Bazzoni, Gianfranco ^a   De Simoni, Maria Grazia ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b INSTITUTE OF BIOCHEMISTRY   (Hungary)

Author keywords

astrocytes; blood brain barrier; ischemia; oxygen glucose deprivation; preconditioning

Indexed keywords

ALBUMIN; CILIARY NEUROTROPHIC FACTOR RECEPTOR; CLAUDIN 5; EVANS BLUE; FLUORESCEIN SODIUM; FLUOROCITRIC ACID; GLIAL FIBRILLARY ACIDIC PROTEIN; INTERLEUKIN 6; MESSENGER RNA; PROTEIN ZO1; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; BRAIN INFARCTION SIZE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; ELECTRIC RESISTANCE; ENDOTHELIUM CELL; GENE EXPRESSION; GLIA CELL; ISCHEMIC PRECONDITIONING; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION;

ANIMALS; ASTROCYTES; BLOOD-BRAIN BARRIER; BRAIN ISCHEMIA; COCULTURE TECHNIQUES; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; INFARCTION, MIDDLE CEREBRAL ARTERY; ISCHEMIC PRECONDITIONING; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; NERVE TISSUE PROTEINS; NEUROGLIA; PHOSPHOPROTEINS;

EID: 79955477787     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/STROKEAHA.110.603266     Document Type: Article

References (24)

1. Dirnagl U, Becker K, Meisel A. Preconditioning and tolerance against cerebral ischaemia: from experimental strategies to clinical use. Lancet Neurol. 2009;8:398-412.
2. Marsh BJ, Williams-Karnesky RL, Stenzel-Poore MP. Toll-like receptor signaling in endogenous neuroprotection and stroke. Neuroscience. 2009; 158:1007-1020.
3. Wegener S, Gottschalk B, Jovanovic V, Knab R, Fiebach JB, Schellinger PD, Kucinski T, Jungehulsing GJ, Brunecker P, Muller B, Banasik A, Amberger N, Wernecke KD, Siebler M, Rother J, Villringer A, Weih M. Transient ischemic attacks before ischemic stroke: preconditioning the human brain? a multicenter magnetic resonance imaging study. Stroke. 2004;35:616-621. (Pubitemid 38280829)
4. Fu Y, Sun JL, Ma JF, Geng X, Sun J, Liu JR, Song YJ, Chen SD. The neuroprotection of prodromal transient ischaemic attack on cerebral infarction. Eur J Neurol. 2008;15:797-801.
5. Lok J, Gupta P, Guo S, Kim WJ, Whalen MJ, van Leyen K, Lo EH. Cell-cell signaling in the neurovascular unit. Neurochem Res. 2007;32: 2032-2045. (Pubitemid 350059847)
6. Deli MA, Abraham CS, Kataoka Y, Niwa M. Permeability studies on in vitro blood-brain barrier models: physiology, pathology, and pharma-cology. Cell Mol Neurobiol. 2005;25:59-127. (Pubitemid 40558585)
7. Masada T, Hua Y, Xi G, Ennis SR, Keep RF. Attenuation of ischemic brain edema and cerebrovascular injury after ischemic preconditioning in the rat. J Cereb Blood Flow Metab. 2001;21:22-33. (Pubitemid 32016836)
8. Hua F, Ma J, Ha T, Kelley J, Williams DL, Kao RL, Kalbfleisch JH, Browder IW, Li C. Preconditioning with a TLR2 specific ligand increases resistance to cerebral ischemia/reperfusion injury. J Neuroimmunol. 2008;199:75-82.
9. An P, Xue YX. Effects of preconditioning on tight junction and cell adhesion ofcerebral endothelial cells. Brain Res. 2009;1272:81-88.
10. Andjelkovic AV, Stamatovic SM, Keep RF. The protective effects of preconditioning on cerebral endothelial cells in vitro. J Cereb Blood Flow Metab. 2003;23:1348-1355. (Pubitemid 37409798)
11. Zhang Y, Park TS, Gidday JM. Hypoxic preconditioning protects human brain endothelium from ischemic apoptosis by Akt-dependent survivin activation. Am J Physiol Heart Circ Physiol. 2007;292:H2573-H2581. (Pubitemid 47084501)
12. Gesuete R, Storini C, Fantin A, Stravalaci M, Zanier ER, Orsini F, Vietsch H, Mannesse ML, Ziere B, Gobbi M, De Simoni MG. Recom-binant C1 inhibitor in brain ischemic injury. Ann Neurol. 2009;66: 332-342.
13. De Simoni MG, Storini C, Barba M, Catapano L, Arabia AM, Rossi E, Bergamaschini L. Neuroprotection by complement (C1) inhibitor in mouse transient brain ischemia. J Cereb Blood Flow Metab. 2003;23: 232-239. (Pubitemid 36188461)
14. Storini C, Rossi E, Marrella V, Distaso M, Veerhuis R, Vergani C, Bergamaschini L, De Simoni MG. C1 inhibitor protects against brain ischemia-reperfusion injury via inhibition of cell recruitment and inflam-mation. Neurobiol Dis. 2005;19:10-17. (Pubitemid 40544719)
15. De Simoni MG, Rossi E, Storini C, Pizzimenti S, Echart C, Bergam-aschini L. The powerful neuroprotective action of C1-inhibitor on brain ischemia-reperfusion injury does not require C1q. Am J Pathol. 2004; 164:1857-1863. (Pubitemid 38529788)
16. Qu YZ, Li M, Zhao YL, Zhao ZW, Wei XY, Liu JP, Gao L, Gao GD. Astragaloside IV attenuates cerebral ischemia-reperfusion-induced increase in permeability of the blood-brain barrier in rats. Eur J Pharmacol. 2009;606:137-141.
17. Voloboueva LA, Suh SW, Swanson RA, Giffard RG. Inhibition of mitochondrial function in astrocytes: implications for neuroprotection. J Neurochem. 2007;102:1383-1394. (Pubitemid 47174241)
18. Capone C, Frigerio S, Fumagalli S, Gelati M, Principato MC, Storini C, Montinaro M, Kraftsik R, De Curtis M, Parati E, De Simoni MG Neurosphere-derived cells exert a neuroprotective action by changing the ischemic microenvironment. PLoS ONE. 2007;2:e373.
19. Cecchelli R, Berezowski V, Lundquist S, Culot M, Renftel M, Dehouck MP, Fenart L. Modelling of the blood-brain barrier in drug discovery and development. Nat Rev Drug Discov. 2007;6:650-661. (Pubitemid 47202487)
20. Escartin C, Bonvento G. Targeted activation of astrocytes: a potential neuroprotective strategy. Mol Neurobiol. 2008;38:231-241.
21. Li L, Lundkvist A, Andersson D, Wilhelmsson U, Nagai N, Pardo AC, Nodin C, Stahlberg A, Aprico K, Larsson K, Yabe T, Moons L, Fother-ingham A, Davies I, Carmeliet P, Schwartz JP, Pekna M, Kubista M, Blomstrand F, Maragakis N, Nilsson M, Pekny M. Protective role of reactive astrocytes in brain ischemia. J Cereb Blood Flow Metab. 2008; 28:468-481. (Pubitemid 351304260)
22. Brillault J, Berezowski V, Cecchelli R, Dehouck MP. Intercommuni-cations between brain capillary endothelial cells and glial cells increase the transcellular permeability of the blood-brain barrier during ischaemia. J Neurochem. 2002;83:807-817. (Pubitemid 35316030)
23. Descamps L, Coisne C, Dehouck B, Cecchelli R, Torpier G. Protective effect of glial cells against lipopolysaccharide-mediated blood-brain barrier injury. Glia. 2003;42:46-58. (Pubitemid 36427420)
24. Krum JM, Mani N, Rosenstein JM. Roles of the endogenous VEGF receptors flt-1 and flk-1 in astroglial and vascular remodeling after brain injury. Exp Neurol. 2008;212:108-117