Design, synthesis, and in vivo characterization of a novel series of tetralin amino imidazoles as γ-secretase inhibitors: Discovery of PF-3084014

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 9, 2011, Pages 2637-2640

  Brodney, Michael A ^a   Auperin, David D ^a   Becker, Stacey L ^a   Bronk, Brian S ^a   Brown, Tracy M ^a   Coffman, Karen J ^a   Finley, James E ^a   Hicks, Carol D ^a   Karmilowicz, Michael J ^a   Lanz, Thomas A ^a   Liston, Dane ^a   Liu, Xingrong ^a   Martin, Barbara Anne ^a   Nelson, Robert B ^a   Nolan, Charles E ^a   Oborski, Christine E ^a   Parker, Christine P ^a   Richter, Karl E G ^a   Pozdnyakov, Nikolay ^a   Sahagan, Barbara G ^a   Schachter, Joel B ^a   Sokolowski, Sharon A ^a   Tate, Barbara ^a   Wood, Douglas E ^a   Wood, Kathleen M ^a   Van Deusen, Jeffrey W ^a   Zhang, Lei ^a   more..

^a PFIZER INC   (United States)

Author keywords

Secretase inhibitors; A Reductions; Marginal zone B cells; Notch; Tetralin imidazoles

Indexed keywords

AMYLOID BETA PROTEIN; GAMMA SECRETASE INHIBITOR; IMIDAZOLE DERIVATIVE; NOTCH RECEPTOR; PF 3084014; TETRALIN AMINO IMIDAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; CONFERENCE PAPER; DRUG DESIGN; DRUG EFFICACY; DRUG SYNTHESIS; GUINEA PIG; IN VIVO STUDY; NONHUMAN;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BIOLOGICAL ASSAY; DRUG DESIGN; ENZYME ACTIVATION; ENZYME INHIBITORS; GUINEA PIGS; IMIDAZOLES; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDRONAPHTHALENES; VALINE;

CAVIA;

EID: 79955467553     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.12.118     Document Type: Conference Paper

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