Proton pump inhibitors, fracture risk and selection bias: Three studies, same database, two answers

Osteoporosis International

Volumn 22, Issue 5, 2011, Pages 1641-1642

  De Vries, F ^a,b,c   Van Staa, T P ^a,b   Leufkens, H G M ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b MEDICINES AND HEALTHCARE PRODUCTS REGULATORY AGENCY   (United Kingdom)

^c SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PROTON PUMP INHIBITOR;

BONE DENSITY; CLINICAL EVALUATION; DATA BASE; DRUG MECHANISM; FOOD AND DRUG ADMINISTRATION; FRACTURE; GASTROESOPHAGEAL REFLUX; HIGH RISK PATIENT; HIP FRACTURE; HUMAN; LETTER; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; THERAPY EFFECT; TREATMENT DURATION; TREATMENT RESPONSE;

FRACTURES, BONE; HUMANS; PROTON PUMP INHIBITORS; RISK ASSESSMENT; SELECTION BIAS;

EID: 79955466670     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-010-1323-1     Document Type: Letter

References (6)

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2. US Food and Drug Administration FDA (2010) Possible fracture risk with high dose, long-term use of proton pump inhibitors. http://www.fda.gov/Drugs/ DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm213206.htm. Accessed 28 May 2010
3. YX Yang JD Lewis S Epstein DC Metz 2006 Long-term proton pump inhibitor therapy and risk of hip fracture JAMA 296 2947 2953 17190895 10.1001/jama.296.24.2947 1:CAS:528:DC%2BD2sXnvVGn (Pubitemid 46021498)
4. JA Kaye H Jick 2008 Proton pump inhibitor use and risk of hip fractures in patients without major risk factors Pharmacotherapy 28 951 959 18657011 10.1592/phco.28.8.951 1:CAS:528:DC%2BD1cXhtVWntrfP
5. F de Vries AL Cooper SM Cockle TP van Staa C Cooper 2009 Fracture risk in patients receiving acid-suppressant medication alone and in combination with bisphosphonates Osteoporos Int 20 1989 1998 19333676 10.1007/s00198-009-0891-4 1:CAS:528:DC%2BD1MXhsVWlsrzM
6. A Lalmohamed S Pouwels C Cooper TP van Staa B Leufkens A de Boer F de Vries 2009 Use of proton pump inhibitors and risk of hip fracture Bone 44 Suppl2 S396 S397 10.1016/j.bone.2009.03.292