Uterine leiomyosarcomas: Tumor size, mitotic index, and biomarkers Ki67, and Bcl-2 identify two groups with different prognosis

Gynecologic Oncology

Volumn 121, Issue 2, 2011, Pages 328-333

  D'Angelo, Emanuela ^a   Espinosa, Inigo ^a   Ali, Rola ^b   Gilks, C Blake ^b   Rijn, Matt Van De ^c   Lee, Cheng Han ^b   Prat, Jaime ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c STANFORD UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Bcl 2; CD163 tumor macrophages; Immunohistochemistry; Ki67; Leiomyosarcoma; Mitotic index; Tumor size

Indexed keywords

CD163 ANTIGEN; KI 67 ANTIGEN; PROTEIN BCL 2; PROTEIN P16; PROTEIN P53;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LEIOMYOSARCOMA; MAJOR CLINICAL STUDY; MITOSIS INDEX; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; SURVIVAL; TISSUE MICROARRAY; TUMOR IMMUNITY; TUMOR VOLUME; UTERUS LEIOMYOSARCOMA;

ADULT; AGED; FEMALE; HUMANS; KI-67 ANTIGEN; LEIOMYOSARCOMA; MICROARRAY ANALYSIS; MIDDLE AGED; MITOTIC INDEX; NEOPLASM PROTEINS; NEOPLASM STAGING; PARAFFIN EMBEDDING; PROGNOSIS; PROTO-ONCOGENE PROTEINS C-BCL-2; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53; UTERINE NEOPLASMS;

EID: 79955466436     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2011.01.022     Document Type: Article

References (38)

1. A. Gadducci, F. Landoni, and E. Sartori Uterine leiomyosarcoma: analysis of treatment failures and survival Gynecol Oncol. 62 1996 25 32 (Pubitemid 26234541)
2. R.L. Giuntoli 2nd, and R.E. Bristow Uterine leiomyosarcoma: present management Curr Opin Oncol. 16 2004 324 327 (Pubitemid 38870037)
3. W.G. McCluggage, U. Haller, R.J. Kurman, and R.A. Kubick-Huch Mixed epithelial and mesenchymal tumours F.A. Tavassoli, P. Devilee, World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs 2003 IARC Press Lyon
4. S.W. Bell, R.L. Kempson, and M.R. Hendrickson Problematic uterine smooth muscle neoplasms. A clinicopathologic study of 213 cases Am J Surg Pathol. 18 1994 535 558 (Pubitemid 24150803)
5. M.R. Hendrickson, F.A. Tavassoli, R.L. Kempson, W.G. Mc Cluggage, U. Haller, and R.A. Kubik-Huch Mesenchymal tumours and related lesions F.A. Tavassoli, P. Devilee, World Health Organization Classification of Tumours. Pathology and genetics of tumours of the breast and female genital organs 2003 IARC Press Lyon
6. E. D'Angelo, L.G. Spagnoli, and J. Prat Comparative clinicopathologic and immunohistochemical analysis of uterine sarcomas diagnosed using the World Health Organization classification system Hum Pathol 40 2009 1571 1585
7. S.R. Guntupalli, P.T. Ramirez, M.L. Anderson, M.R. Milam, D.C. Bodurka, and A. Malpica Uterine smooth muscle tumor of uncertain malignant potential: a retrospective analysis Gynecol Oncol. 113 2009 324 326
8. P.P. Ip, A.N. Cheung, and P.B. Clement Uterine Smooth Muscle Tumors of Uncertain Malignant Potential (STUMP): a clinicopathologic analysis of 16 cases Am J Surg Pathol 33 2009 992 1005
9. V.M. Abeler, O. Røyne, S. Thoresen, H.E. Danielsen, J.M. Nesland, and G.B. Kristensen Uterine sarcomas in Norway. A histopathological and prognostic survey of a total population from 1970 to 2000 including 419 patients Histopathology. 54 2009 355 364
10. D. Denschlag, I. Masoud, G. Stanimir, and L. Gilbert Prognostic factors and outcome in women with uterine sarcoma Eur J Surg Oncol. 33 2007 91 95 (Pubitemid 46156623)
11. R.L. Giuntoli 2nd, D.S. Metzinger, and C.S. Di Marco Retrospective review of 208 patients with leiomyosarcoma of the uterus: prognostic indicators, surgical management, and adjuvant therapy Gynecol Oncol. 89 2003 460 469 (Pubitemid 36687793)
12. R. Koivisto-Korander, R. Butzow, A.M. Koivisto, and A. Leminen Clinical outcome and prognostic factors in 100 cases of uterine sarcoma: experience in Helsinki University Central Hospital 1990-2001 Gynecol Oncol. 111 2008 Oct 74 81
13. W.L. Wang, R.A. Soslow, and M. Hensley Histopathologic prognostic factors in stage I uterine leiomyosarcomas (Ut-LMS): a clinicopathologic study of 28 cases Mod Path 2007 217A
14. FIGO staging for uterine sarcomas Int J Gynaecol Obstet 104 2009 179
15. S.E. Akhan, E. Yavuz, and A. Tecer The expression of Ki-67, p53, estrogen and progesterone receptors affecting survival in uterine leiomyosarcomas A clinicopathologic study. Gynecol Oncol. 99 2005 36 42 (Pubitemid 41354580)
16. K.A. Atkins, N. Arronte, C.J. Darus, and L.W. Rice The use of p16 in enhancing the histologic classification of uterine smooth muscle tumors Am J Surg Pathol. 32 2008 98 102
17. K. Bodner, B. Bodner-Adler, O. Kimberger, K. Czerwenka, and K. Mayerhofer Bcl-2 receptor expression in patients with uterine smooth muscle tumors: an immunohistochemical analysis comparing leiomyoma, uterine smooth muscle tumor of uncertain malignant potential, and leiomyosarcoma J Soc Gynecol Investig. 11 2004 187 191 (Pubitemid 38406098)
18. B. Bodner-Adler, K. Bodner, K. Czerwenka, O. Kimberger, S. Leodolter, and K. Mayerhofer Expression of p16 protein in patients with uterine smooth muscle tumors: an immunohistochemical analysis Gynecol Oncol. 96 2005 62 66 (Pubitemid 39612418)
19. L. Chen, and B. Yang Immunohistochemical analysis of p16, p53, and Ki-67 expression in uterine smooth muscle tumors Int J Gynecol Pathol. 27 2008 326 332
20. K. Mittal Demopoulos RI.MIB-1 (Ki-67), p53, estrogen receptor, and progesterone receptor expression in uterine smooth muscle tumors Hum Pathol. 32 2001 984 987 (Pubitemid 32911322)
21. C.J. O'Neill, H.A. McBride, L.E. Connolly, and W.G. McCluggage Uterine leiomyosarcomas are characterized by high p16, p53 and MIB1 expression in comparison with usual leiomyomas, leiomyoma variants and smooth muscle tumours of uncertain malignant potential Histopathology. 50 2007 851 858 (Pubitemid 46850073)
22. Y.L. Zhai, Y. Kobayashi, and A. Mori Expression of steroid receptors, Ki-67, and p53 in uterine leiomyosarcomas Int J Gynecol Pathol. 18 1999 20 28 (Pubitemid 29028841)
23. M.J. Bissell, and D. Radisky Putting tumours in context Nat Rev Cancer 1 2001 46 54 Review (Pubitemid 33741880)
24. B. Elenbaas, and R.A. Weinberg Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation Exp Cell Res 264 2001 169 184 Review (Pubitemid 32989090)
25. I. Espinosa, A.H. Beck, C.H. Lee, S. Zhu, K.D. Montgomery, R.J. Marinelli, K.N. Ganjoo, T.O. Nielsen, C.B. Gilks, R.B. West, and M. van de Rijn Coordinate expression of colony-stimulating factor-1 and colony-stimulating factor-1-related proteins is associated with poor prognosis in gynecological and nongynecological leiomyosarcoma Am J Pathol. 174 2009 2347 2356
26. A. Nocito, J. Kononen, O.P. Kallioniemi, and G. Sauter Tissue microarrays (TMAs) for high-throughput molecular pathology research Int J Cancer. 94 2001 1 5 (Pubitemid 32801745)
27. C.L. Liu, K.D. Montgomery, and Y. Natkunam TMA-Combiner, a simple software tool to permit analysis of replicate cores on tissue microarrays Mod Pathol 18 2005 1641 1648 (Pubitemid 41670665)
28. C.L. Liu, W. Prapong, and Y. Natkunam Software tools for high-throughput analysis and archiving of immunohistochemistry staining data obtained with tissue microarrays Am J Pathol 161 2002 1557 1565 (Pubitemid 35265516)
29. D.S. Kapp, J.Y. Shin, and J.K. Chan Prognostic factors and survival in 1396 patients with uterine leiomyosarcomas: emphasis on impact of lymphadenectomy and oophorectomy Cancer 112 2008 820 830 (Pubitemid 351240576)
30. K. Mayerhofer, A. Obermair, and G. Windbichler Leiomyosarcoma of the uterus: a clinicopathologic multicenter study of 71 cases Gynecol Oncol. 74 1999 196 201 (Pubitemid 29377212)
31. E. D'Angelo, and J. Prat Uterine Sarcomas A review. Gynecol Oncol. 116 2010 131 139
32. H.L. Evans, S.P. Chawla, C. Simpson, and K.P. Finn Smooth muscle neoplasms of the uterus other than ordinary leiomyoma. A study of 46 cases with emphasis on diagnostic criteria and prognostic factors Cancer 62 1988 2239 2247 (Pubitemid 18261867)
33. B. Larson, C. Silfversward, B. Nilsson, and F. Petterson Prognostic factors in uterine leiomyosarcoma: a clinicopathologic study of 143 cases. The Radiumhemmet series, 1936-1981 Acta Oncol 29 1990 185 191 (Pubitemid 20145283)
34. R. Nordal, G.B. Kristensen, J. Kaern, A.E. Stenwig, E.O. Pettersen, and C.G. Trope The prognostic significance of stage, tumor size, cellular atypia and DNA ploidy in uterine leiomyosarcoma Acta Oncol 34 1995 797 802
35. G. Garg, J.P. Shah, J.R. Liu, C.S. Bryant, S. Kumar, A. Munkarah, and R.T. Morris Validation of tumor size as staging variable in the revised International Federation of Gynecology and Obstetrics stage I leiomyosarcoma: a population based study Int J Gynecol Cancer 20 2010 1201 1206
36. F.J. Major, J.A. Blessing, and S.G. Silverberg Prognostic factors in early stage uterine sarcoma: a Gynecologic Oncology Group study Cancer 71 1993 1702 1709 (Pubitemid 23056094)
37. P. Pautier, C. Genestie, A. Rey, P. Morice, B. Roche, C. Lhommé, C. Haie-Meder, and P. Duvillard Analysis of clinicopathologic prognostic factors for 157 uterine sarcomas and evaluation of a grading score validated for soft tissue sarcoma Cancer. 88 2000 1425 1431 (Pubitemid 30155181)
38. Y.L. Zhai, T. Nikaido, T. Toki, A. Shiozawa, A. Orii, and S. Fujii Prognostic significance of bcl-2 expression in leiomyosarcoma of the uterus Br J Cancer. 80 1999 1658 1664 (Pubitemid 29308652)