Is GPR30 the membrane aldosterone receptor postulated 20 years ago?

Hypertension

Volumn 57, Issue 5, 2011, Pages

  Wendler, Alexandra ^a   Wehling, Martin ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; CANRENONE; DEXAMETHASONE; EPLERENONE; G PROTEIN COUPLED RECEPTOR 30; MYOSIN LIGHT CHAIN; SODIUM PROTON EXCHANGE PROTEIN; SPIRONOLACTONE;

ENZYME BINDING; ENZYME PHOSPHORYLATION; HUMAN; LETTER; LEUKOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ANIMALS; CELL MEMBRANE; RECEPTORS, ALDOSTERONE; RECEPTORS, G-PROTEIN-COUPLED;

EID: 79955465781     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.111.170977     Document Type: Letter

References (5)

1. Gros R, Ding Q, Sklar LA, Prossnitz EE, Arterburn JB, Chorazyczewski J, Feldman RD. GPR30 expression is required for the mineralocorticoid receptor-independent rapid vascular effects of aldosterone. Hypertension. 2011;57:442-451.
2. Wehling M, Käsmayr J, Theisen K. Rapid effects of mineralocorticoids on sodium-proton exchanger: genomic or nongenomic pathway? Am J Physiol. 1991;260:E719-E726.
3. Christ M, Douwes K, Eisen C, Bechtner G, Theisen K, Wehling M. Rapid effects of aldosterone on sodium transport in vascular smooth muscle cells. Hypertension. 1995;25:117-123.
4. Grossmann C, Benesic A, Krug AW, Freudinger R, Mildenberger S, Gassner B, Gekle M. Human mineralocorticoid receptor expression renders cells responsive for nongenotropic aldosterone action. Mol Endocrinol. 2005;19: 1697-1710. (Pubitemid 41007884)
5. Wildling L, Hinterdorfer P, Kusche-Vihrog K, Treffner Y, Oberleithner H. Aldosterone receptor sites on plasma membrane of human vascular endo-thelium detected by a mechanical nanosensor. Pflugers Arch. 2009;458: 223-230.