In situgel: Development, evaluation and optimization using 32 factorial design

Journal of Pharmaceutical Sciences and Research

Volumn 3, Issue 4, 2011, Pages 1156-1162

  Rathod, Hetangi ^a   Patel, Vishnu ^a   Modasiya, Moin ^a  

^a APMC College of Pharmaceutical Education and Research   (India)

Author keywords

In situ gelation; Sodium alginate; Sustain release

Indexed keywords

ALGINIC ACID; AMBROXOL; CALCIUM CHLORIDE;

ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG STABILITY; GEL; GELATION; IN VITRO STUDY; PH; PROCESS OPTIMIZATION; VISCOSITY;

EID: 79955462564     PISSN: None     EISSN: 09751459     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Jain NK. Progress in Controlled and Novel Drug Delivery System.1st edition, New Delhi, CBS Publisher; 2004: 76-77.
2. Muthusamy K, Govindarazan G, Ravi T. Preperation and evaluation of lansoprazole floating micro pellets. Int J Sci 2005; 67:75-79.
3. Vyas SP, Khar RK. Controlled drug delivery: concepts and advances. 1st ed. Delhi, India: Vallabh Prakashan; 2002:156-157.
4. Sato Y, Kawashima Y, Takeuchi H, Yamamoto H, Fujibayashi Y. Pharmacoscintigraphic evaluation of riboflavin-containing micro balloons for a floating controlled drug delivery system in healthy humans. J Control Rel. 2004; 98:75-85.
5. Miyazaki, S., Kubo, W., Attwood, D. Oral sustained delivery of theophylline using in situ gelation of sodium alginate. J. Control. Release. 2000;67: 275-280.
6. Madan M, Bajaj A, Lewis S, In situ forming polymeric drug delivery system, Indian journal of pharmaceutical science. 2009;71: 242-250.
7. Robinson JR and Eriksen SP. Theoretical formulation of sustained release dosage forms. J. Pharm. Sci. 1966; 53: 1254-1263.
8. Karasulu E, Karasuslu HY, Ertan G, Kirilmaz L and Guneri T. Extended release lipophillic indomethacin microspheres: formulation factors and mathematical equations fitted drug release rates. Eur J Pharm Sci.2003; 19: 99-104.
9. Patel R.P. Formulation, evaluation and optimization of stomach specific in situ gel of clarithromycin and metronidazole benzoate. Int J Drug Del. 2010; 2: 141-153.
10. Zatz JL and Woodford DW. Prolonged release of theophylline from aqueous suspension. Drug.Dev.Ind.Pharm.1987; 13: 2159-2178.
11. Kedzierewicz F, Lombry C, Rios R., Hoffman M, Maincent P. Effect of the formulation on the in vitro release of propranolol from gellan beads.
12. Korsmeyer RW, Gurney R, Doelker E, Buri P and Peppas NA. Mechanisms of solute release from porous hydrophilic polymers. J. Pharm. Sci.1983; 15:25-35.