The effects of glutamine on hepatic ischemia reperfusion injury in rats

Hippokratia

Volumn 15, Issue 2, 2011, Pages 161-166

  Sözen, Selim ^a   Kisakurek M ^b   Yildiz, F ^c   Gonultas M ^d   Dincel A S ^d  

^a Kayseri Training and Research Hospital   (Turkey)

^b Elazig training and research Hospital General Surgery   (Turkey)

^c HARRAN UNIVERSITY   (Turkey)

^d ANKARA TRAINING AND RESEARCH HOSPITAL   (Turkey)

Author keywords

Effects; Glutamine; Ischemia reperfusion; Liver

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTIOXIDANT; ASPARTATE AMINOTRANSFERASE; CATALASE; ENDOTOXIN; GLUTAMINE; LACTATE DEHYDROGENASE; MYELOPEROXIDASE; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; HISTOPATHOLOGY; LIVER ISCHEMIA; LIVER PARENCHYMA; LIVER PROTECTION; MALE; MICROSCOPY; NONHUMAN; OXIDATIVE STRESS; RAT; REPERFUSION INJURY; TREATMENT OUTCOME;

EID: 79955459050     PISSN: 11084189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Hassan-Khabbar S, Cottart CH, Wendum D, Vibert F, Clot JP, Savouret JF, Conti M, Nivet-Antoine V. Postischemic treatment by trans-resveratrol in rat liver ischemiareperfusion: a possible strategy in liver surgery. Liver Transpl. 2008; 14: 451-459.
2. Montalvo-Jave EE, Escalante-Tattersfield T, Ortega-Salgado JA, Pina E, Geller DA. Factors in the pathophysiology of the liver ischemia-reperfusion injury. J Surg Res. 2008; 147: 153-159.
3. Melis GC, ter Wengel N, Boelens PG, van Leeuwen PA. Glutamine: recent developments in research on the clinical significance of glutamine. Curr Opin Clin Nutr Metab Care. 2004; 7: 59-70.
4. Houdijk AP, Rijnsburger ER, Jansen J, Wesdorp RI, Weiss JK, McCamish MA, et al. Randomised trial of glutamine-enriched enteral nutrition on infectious morbidity in patients with multiple trauma. Lancet. 1998; 352: 772-776.
5. Harward TR, Coe D, Souba WW, Klingman N, Seeger JM. Glutamine preserves gut glutathione levels during intestinal ischemia/reperfusion. J Surg Res. 1994; 56: 351-355.
6. Prem JT, Eppinger M, Lemmon G, Miller S, Nolan D, Peoples J. The role of glutamine in skeletal muscle ischemia/reperfusion injury in the rat hind limb model. Am J Surg. 1999; 178:147-150.
7. Schauer RJ, Kalmuk S, Gerbes AL, Leiderer R, Meissner H, Schildberg FW,et al. Intravenous administration of glutathione protects parenchymal and non-parenchymal liver cells against reperfusion injury following rat liver transplantation. World J Gastroenterol. 2004; 10: 864-870.
8. Bolukbas C, Bolukbas FF, Horoz M, Aslan M, Celik H, Erel O. Increased oxidative stress associated with the severity of the liver disease in various forms of hepatitis B virus infection. BMC Infect Dis. 2005; 5: 95.
9. Wei H, Frenkel K. Relationship of oxidative events and DNA oxidation in SENCAR mice to in vivo promoting activity of phorbol ester-type tumor promoters. Carcinogenesis. 1993; 14: 1195-1201.
10. Goth L. A simple method for determination of serum catalase activity and revision of reference range. Clin Chim Acta. 1991; 196: 143-151.
11. Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem. 2005; 38: 1103-1111.
12. Erel O. A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem. 2004; 37: 112-119.
13. Ozturk H, Gezici A, Ozturk H. The effect of celecoxib, a selective COX-2 inhibitor, on liver ischemia/reperfusion-induced oxidative stres in rats. Hepatol Res. 2006;34:76-83.
14. Shin T, Kuboki S, Huber N, Eismann T, Galloway E, Schuster R, et al. Activation of peroxisome proliferator-activated receptor-gamma during hepatic ischemia is age-dependent. J Surg Res. 2008; 147: 200-205.
15. van Gulik TM, de Graaf W, Dinant S, Busch OR, Gouma DJ. Vascular occlusion techniques during liver resection. Dig Surg. 2007; 24: 274-281.
16. He XS, Ma Y, Wu LW, Wu JL, Hu RD, Chen GH, et al. Dynamical changing patterns of glycogen and enzyme histochemical activities in rat liver graft undergoing warm ischemia injury. World J Gastroenterol. 2005; 11: 2662-2665.
17. Sun K, Liu ZS, Sun Q. Role of mitochondria in cell apoptosis during hepatic ischemia-reperfusion injury and protective effect of ischemic postconditioning. World J Gastroenterol. 2004; 10: 1934-1938.
18. Oshimi Y, Miyazaki S. Fas antigen-mediated DNA fragmentation and apoptotic morphologic changes are regulated by elevated cytosolic Ca2+ level. J Immunol. 1995; 54: 599-609.
19. Gantner F, Leist M, Jilg S, Germann PG, Freudenberg MA, Tiegs G. Tumor necrosis factor-induced hepatic DNA fragmentation as an early marker of T cell-dependent liver injury in mice. Gastroenterology. 1995; 109: 166-176.
20. Harward TR, Coe D, Souba WW, Klingman N, Seeger JM. Glutamine preserves gut glutathione levels during intestinal ischemia/reperfusion. J Surg Res. 1994; 56: 351-355.
21. Prem JT, Eppinger M, Lemmon G, Miller S, Nolan D, Peoples J. The role of glutamine in skeletal muscle ischemia/reperfusion injury in the rat hind limb model. Am J Surg. 1999; 178:147-150.
22. Schauer RJ, Kalmuk S, Gerbes AL, Leiderer R, Meissner H, Schildberg FW, et al. Intravenous administration of glutathione protects parenchymal and non-parenchymal liver cells against reperfusion injury following rat liver transplantation. World J Gastroenterol. 2004; 10: 864-870.
23. Armeni T, Ghiselli R, Balercia G, Goffi L, Jassem W, Saba V, Principato G. Glutathione and ultrastructural changes in inflow occlusion of rat liver. J Surg Res. 2000; 88:207-214.
24. Scheppach W, Loges C, Bartram P, Christl SU, Richter F, Dusel G, et al. Effect of free glutamine and alanyl-glutamine dipeptide on mucosal proliferation of the human ileum and colon. Gastroenterology. 1994; 107: 429-434.
25. Blikslager AT, Rhoads JM, Bristol DG, Roberts MC, Argenzio RA. Glutamine and transforming growth factor-alpha stimulate extracellular regulated kinases and enhance recovery of villous surface area in porcine ischemic-injured intestine. Surgery. 1999; 125: 186-194.
26. Gantner F, Leist M, Jilg S, Germann PG, Freudenberg MA, Tiegs G. Tumor necrosis factor-induced hepatic DNA fragmentation as an early marker of T cell-dependent liver injury in mice. Gastroenterology. 1995; 109: 166-176.
27. Chouker A, Martignoni A, Schauer RJ, Dugas M, Schachtner T, Kaufmann I, et al. Alpha-gluthathione S-transferase as an early marker of hepatic ischemia/reperfusion injury after liver resection. World J Surg. 2005; 29: 528-534.
28. Yabe Y, Kobayashi N, Nishihashi T, Takahashi R, Nishikawa M, Takakura Y, et al. Prevention of neutrophil-mediated hepatic ischemia/reperfusion injury by superoxide dismutase and catalase derivatives. J Pharmacol Exp Ther. 2001;298:894-899.
29. Cetinkaya A, Bulbuloglu E, Kurutas EB, Kantarceken B. Nacetylcysteine ameliorates methotrexate-induced oxidative liver damage in rats. Med Sci Monit. 2006; 12: BR274-BR278.
30. Harada N, Okajima K, Kushimoto S, Isobe H, Tanaka K. Antithrombin reduces ischemia/reperfusion injury of rat liver by increasing the hepatic level of prostacyclin. Blood. 1999:157-164.